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Non Barbiturates Hypnotic Agents

Non Barbiturates Hypnotic Agents. Vicente Gonzalez CRNA, MS Assistant Professor Florida International University. OBJECTIVES. Explain the mechanism of action of nonbarbiturate IV anesthetics. Discuss the pharmacokinetic properties of propofol, ketamine, and etomidate.

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Non Barbiturates Hypnotic Agents

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  1. Non Barbiturates Hypnotic Agents Vicente Gonzalez CRNA, MS Assistant Professor Florida International University

  2. OBJECTIVES • Explain the mechanism of action of nonbarbiturate IV anesthetics. • Discuss the pharmacokinetic properties of propofol, ketamine, and etomidate. • Compare the effects that nonbarbiturate IV anesthetics have on organ systems.

  3. OBJECTIVES • Discuss clinical uses of propofol, ketamine, and etomidate. • State specific contraindications of nonbarbiturate IV anesthetics in the clinical setting. • List potential side effects associated with nonbarbiturate IV anesthetics.

  4. REFERENCES Morgan, G.E., Mikhail, M.S., and Murray, M.J. (2006). Clinical Anesthesiology. (4th Ed.) New York, NY: McGraw-Hill. Nagelhout, J.J. and Naglaniczny, K.L. (2005). NurseAnesthesia. (3rd Ed.) St. Louis, MO: Elsevier-Saunders

  5. REFERENCES Stoelting, R.K. (2006). Pharmacology & Physiology in Anesthesia Practice. (4th Ed.) Philadelphia, PA: J.B. Lippincott Company.

  6. Non barbiturate Agents • Agents • Uses • PK-PD • Effects on Organ Systems • Induction Doses • Contraindications

  7. Non barbiturate Agents • Propofol • Etomidate • Ketamine

  8. Non barbiturate Agents • Propofol • Chemical Structure • Commercial Preparations • MOA

  9. Non barbiturate Agents • Chemical structure of propofol

  10. Non barbiturate Agents • Propofol cont’d. • Pharmacokinetics • Clinical Uses • Other Uses

  11. Non barbiturate Agents • Propofol cont’d • Organ System Effects • CNS • Cardiovascular • Respiratory • Renal/Hepatic

  12. Non barbiturate Agents • Propofol cont’d • Contraindications

  13. Non barbiturate Agents • ETOMIDATE • Chemical Structure • Commercial Preparations • MOA

  14. Non barbiturate Agents • Chemical Structure of Etomidate

  15. Non barbiturate Agents • Etomidate cont’d • Pharmacokinetics • Clinical Uses • Other Uses

  16. Non barbiturate Agents • Etomidate cont’d • Organ System Effects • CNS • Cardiovascular • Respiratory • Renal/Hepatic • Other

  17. Non barbiturate Agents • Etomidate’s pathway of inhibition of cortisol and other corticosteroids

  18. Non barbiturate Agents • Etomidate cont’d • Contraindications

  19. Non barbiturate Agents • Ketamine • Chemical Structure • Commercial Preparations • MOA

  20. Non barbiturate Agents • Chemical Structure of Ketamine

  21. Non barbiturate Agents • Ketamine cont’d • Pharmacokinetics • Clinical Uses • Other Uses

  22. Non barbiturate Agents • Ketamine cont’d • Organ System Effects • CNS • Cardiovascular • Respiratory • Renal/Hepatic • Other

  23. Non barbiturate Agents • Ketamine cont’d • Contraindications

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