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Understanding Polycythemia Vera

Polycythemia vera (PV) is a rare, chronic blood disorder characterized by an overproduction of red blood cells, white blood cells, and platelets in the bone marrow. This overproduction can lead to increased blood volume and viscosity, causing complications such as blood clots, strokes, and heart attacks. PV is one of the myeloproliferative neoplasms, a group of disorders caused by abnormal proliferation of blood cells.

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Understanding Polycythemia Vera

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  1. www.bestbmt.com • www.bestbmt.com BEST BMT Dr.Pawan Kumar Singh Dr Pawan Kumar Singh Dr Pawan Kumar Singh has the experience of performing more than 500 bone marrow transplants (including Autologous /Allogenic /Haplo /MDU )for both malignant and non-malignant disorders.

  2. Content List Introduction Polycythemia Vera Symptoms Of PV Causes Of PV Treatment Options

  3. Introduction This comprehensive guide delves into Polycythemia Vera (PV), a rare hematologic condition characterized by the excessive production of red blood cells in the bone marrow. Classified under myeloproliferative neoplasms, PV causes an overabundance of blood cells, which thickens the blood and leads to potential complications. Throughout this exploration, we'll delve into the intricate details of PV, discussing its symptoms, causes, diagnostic methods, and treatment options. Furthermore, we'll underscore the significance of seeking expert medical assistance, including the quest for the finest bone marrow transplant (BMT) Specialist In Delhi.

  4. Understanding Polycythemia Vera Polycythemia Vera originates from a mutation in the bone marrow's stem cells, leading to the uncontrolled production of red blood cells. This overproduction thickens the blood, making it flow more sluggishly through the body's blood vessels, increasing the risk of clotting. PV can affect individuals of any age but is more common in adults around 60 years of age.

  5. Symptoms of Polycythemia Vera • Headaches: Frequent and severe headaches are a common complaint among PV patients. • Fatigue: Due to the thickened blood, the body's organs may not receive adequate oxygen, leading to persistent fatigue. • Itching: Unexplained itching, particularly after exposure to warm water, is a common symptom of PV.

  6. Blurred vision: The increased viscosity of blood can affect blood flow to the eyes, resulting in blurred vision. • Dizziness or lightheadedness: Reduced blood flow to the brain can cause dizziness or lightheadedness.

  7. Causes of Treatment Options The exact cause of PV remains unknown, although it is primarily linked to a mutation in the JAK2 gene. This mutation leads to the uncontrolled production of red blood cells in the bone marrow. While the specific triggers for this mutation are unclear, certain risk factors may increase the likelihood of developing PV, including genetic predisposition and environmental factors.

  8. Diagnosis of Polycythemia Vera • Diagnosing PV involves a combination of medical history review, physical examination, and laboratory tests. Key diagnostic tests include: • Complete Blood Count (CBC): Elevated red blood cell count is a primary indicator of PV. • JAK2 Mutation Test: This genetic test helps identify the JAK2 mutation present in the majority of PV patients. • Bone Marrow Biopsy: A sample of bone marrow is examined to confirm the diagnosis and assess the extent of cell proliferation.

  9. Treatment Options for Polycythemia Vera • Phlebotomy: This procedure involves removing a specific amount of blood to reduce the thickness and viscosity of the blood. • Medications: Prescription medications such as hydroxyurea or interferon-alpha may be prescribed to suppress the bone marrow's overactivity. • Aspirin Therapy: Low-dose aspirin is often recommended to reduce the risk of blood clots. • Biological Therapies: In some cases, biological therapies such as JAK inhibitors may be used to target the underlying genetic mutation

  10. Dr. Pawan Kumar Singh • BLK-MAX SUPER SPECIALITY HOSPITAL, RAJENDRA PLACE NEW DELHI MD-Medicine, DM (Haemato- Oncology AIIMS) 09:00 AM - 05:00 PM BONE MARROW TRANSPLANT (BMT) SPECIALIST Thank • BOOK APPOINTMENT • +91-9354700860/ 8750637212 You! Get In Contact!

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