OS SiA-Artificial Intelligence Digital Pathology Scanner

1. OS-SiA: Scan, Index, Analyze World’s First AI-Enabled Scanner A New Generation AI-Enabled Digital Scanner That Allows To Scan, Index And Analyze The Tissue Slides – All At The Same Time Usability The AI based modules in the framework can be trained for classification problems (e.g. tumor vs benign etc.). User can train the module by labelling the segmented cellular objects for classification and selecting the features generated by the feature engineering algorithms. This trained model can be saved for analyzing new images to be scanned. Advantages • The AI scanner has custom Optra’s algorithm in the embedded AI framework with plugin architecture. • The framework consists of core Optra’s imaging library, open source libraries like OpenCV and AI modules for training • the classifiers. • The framework defines the interfaces and provides API’s to process the images. This enables the user to write an • algorithm plugin for image analysis and classification of recognized cellular objects. • The custom algorithms provide real time ROI detection while scanning, cell quantification for IHC/HNE markers, rare • event detection, morphological measurements etc. built using the core library. • The whole slide image can be viewed in local / web based / mobility-based image viewer. OPTRASCAN INC.,CA USA +1 (408) 524-5300 OptraSCAN® is an ISO13485 certified company OptraSCAN® whole slide scanners are CE marked for IVD use OptraSCAN® systems are for research use in North America info@optrascan.com www.optrascan.com @OptraSCAN

2. OptraSCAN® is an ISO 13485 certified company OptraSCAN® systems are CE mark for IVD use OptraSCAN systems are for research use only in North America Providing Accurate, Rapid and Reproducible Assessment Nuclear Biomarker • Identification of optical density vectors • Computer assisted whole-slide & Regions of Interest assessment for quantification of nuclear algorithm • Easily tunable training & classifying modules • Generation and quantification of clinically relevant data for each case • Batch processing and single slide analysis Membrane Biomarker • Highly reproducible and accurate score generation • IHC dual-plex analysis for each biomarker analyzed • User validation through exposed parameters opened for user interaction • Stroke detection algorithm for filtering out residual/background staining OptraSCAN Inc. 100 Century Center Court, Suite 410, San Jose, CA 95112, USA, Tel : +1-408-524-5300 OptraSCAN India Pvt. Ltd. Qubix SEZ, Hinjewadi Phase I Pune, Maharashtra 020-66540900 info@optrascan.com www.optrascan.com

3. OptraSCAN® is an ISO 13485 certified company OptraSCAN® systems are CE mark for IVD use OptraSCAN systems are for research use only in North America Immuno-Oncology • Fully automated solution for interpretation of PD-L1 IHC expression • Score generation based on the number of PD-L1 positive cells in relation to total tumor and immune cells in a single read • Computer aided region detection system based for automated evaluation of tumor nests Prostate Cancer • End to end, fully automated solution for prostate cancer • ANN (artificial neural network) based classifier • ML based histological assessment of architectural patterns OptraSCAN Inc. 100 Century Center Court, Suite 410, San Jose, CA 95112, USA, Tel : +1-408-524-5300 OptraSCAN India Pvt. Ltd. Qubix SEZ, Hinjewadi Phase I Pune, Maharashtra 020-66540900 info@optrascan.com www.optrascan.com