Duolin Rotacaps (Generic Ipratropium And Levalbuterol Rotacaps)

1. Duolin Rotacaps (Generic Ipratropium Bromide And Levalbuterol Sulphate Rotacaps) © The Swiss Pharmacy

2. Duolin Rotacaps (Generic Ipratropium Bromide And Levalbuterol Sulphate Rotacaps) Duolin Rotacaps (Generic Ipratropium Bromide And Levosalbutamol Sulphate (Levalbuterol Sulphate) Rotacaps) are used for the treatment or prevention of bronchospasm in adults, adolescents, and children (4 years of age and older) with reversible obstructive airway diseases like asthma and COPD, including chronic bronchitis and emphysema. Duolin Rotacaps are a combination of an anticholinergic and beta-adrenergic used for patients with chronic obstructive pulmonary disease (COPD) on a regular aerosol bronchodilator who continue to have evidence of bronchospasm and who require a second bronchodilator. © The Swiss Pharmacy

3. Duolin Rotacaps (Generic Ipratropium Bromide And Levalbuterol Sulphate Rotacaps) Duolin Rotacaps are manufactured by Cipla Limited, India in the strength of 140mcg (40 mcg of Ipratropium Bromide and 100mcg of Levosalbutamol). © The Swiss Pharmacy

4. Duolin Rotacaps (Generic Ipratropium Bromide And Levalbuterol Sulphate Rotacaps) Ipratropium Bromide Chemical Structure © The Swiss Pharmacy

5. Duolin Rotacaps (Generic Ipratropium Bromide And Levalbuterol Sulphate Rotacaps) Levalbuterol Sulphate Chemical Structure © The Swiss Pharmacy

6. Duolin Rotacaps (Generic Ipratropium Bromide And Levalbuterol Sulphate Rotacaps) The active ingredients contained in Duolin Rotacaps are Ipratropium Bromide and Levalbuterol Sulphate (Levosalbutamol Sulphate). Each puff contains 100 mcg of Levalbuterol (Levosalbutamol) and 40 mcg of Ipratropium Bromide. © The Swiss Pharmacy

7. Duolin Rotacaps (Generic Ipratropium Bromide And Levalbuterol Sulphate Rotacaps) Uses of Duolin Rotacaps : Duolin Rotacaps (Ipratropium Bromide and Levalbuterol Sulphate) combination is used to help control the symptoms (wheezing and shortness of breath) of lung diseases, such as asthma, and chronic obstructive pulmonary disease-COPD which includes chronic bronchitis and emphysema. It is also used to treat air flow blockage and prevent the worsening of chronic obstructive pulmonary disease (COPD) in patients who need another medicine. Ipratropium Bromide and Levalbuterol Sulphate belong to the family of medicines known as bronchodilators. Bronchodilators are medicines that are breathed in through the mouth to open up the bronchial tubes (air passages) in the lungs. Both drugs work by relaxing the muscles around the airways so that they open up and you can breathe more easily. Controlling symptoms of breathing problems can decrease time lost from work or school. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9907_Duolin-Rotacaps.html https://www.theswisspharmacy.com/product_info.php?info=p9907_Duolin-Rotacaps.html © The Swiss Pharmacy

8. Duolin Rotacaps (Generic Ipratropium Bromide And Levalbuterol Sulphate Rotacaps) Recommended Adult Dosage The dosage of Duolin Rotacaps Duolin Rotacaps (Generic Ipratropium and Levalbuterol Rotacaps) is is 1 rotacap, four times a day. Patients may take additional inhalations as required; however, the total number of rotacaps should not exceed 6 in 24 hours. Duolin Rotacaps should be used only with the Cipla Rotahaler/ Revolizer. Duolin Rotacaps must not be swallowed. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9907_Duolin-Rotacaps.html https://www.theswisspharmacy.com/product_info.php?info=p9907_Duolin-Rotacaps.html © The Swiss Pharmacy

9. Duolin Rotacaps (Generic Ipratropium Bromide And Levalbuterol Sulphate Rotacaps) Recommended Adult Dosage Duolin Rotacaps (Generic Ipratropium and Levalbuterol Rotacaps) are used in a plastic device called a Rotahaler. When used in your Cipla Rotahaler (Generic HandiHaler device), your Duolin Rotacaps provide a measured amount of medicine for you to breathe into your lungs. Your Duolin Rotacaps help you to breathe more easily. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9907_Duolin-Rotacaps.html https://www.theswisspharmacy.com/product_info.php?info=p9907_Duolin-Rotacaps.html © The Swiss Pharmacy

10. Duolin Rotacaps (Generic Ipratropium Bromide And Levalbuterol Sulphate Rotacaps) How To Use The Rotahaler: 1.Hold the Rotahaler vertically and position the two halves of the Rotahaler such that the fin is not directly below the rotacap hole. 2.Remove the rotacap from its bottle and insert it into the rotacap hole with its transparent end facing downwards 3.Hold the mouth piece firmly with one hand and rotate the base 4.Breathe out fully and place the mouthpiece of the Rotahaler between your teeth. 5.Close your lips tightly around it & tilt your head slightly backward & breathe in through the mouth rapidly & deeply. 6.Hold your breath for 10 seconds or for as long as you are comfortable and then breathe out normally. In case some powder remains repeat step 4. 7.Open the Rotahaler and dispose the empty capsule. 8.You can continue to use your Rotahaler daily for up to 6 months. Then discard it and replace with a new one. © The Swiss Pharmacy

11. Duolin Rotacaps (Generic Ipratropium Bromide And Levalbuterol Sulphate Rotacaps) Contraindications ➔Duolin Rotacaps are contraindicated in patients with a known hypersensitivity to Ipratropium Bromide, Levosalbutamol Sulphate Racemic Albuterol or any component of the tablet. Reactions have included urticaria, angioedema, rash, bronchospasm, anaphylaxis, and oropharyngeal edema ➔Administration of Ipratropium bromide is contraindicated in patients who are hypersensitive to atropine or its derivatives. ➔Duolin Rotacaps are contraindicated in patients with a history of hypersensitivity to soya lecithin or related food products such as soybean and peanut. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9907_Duolin-Rotacaps.html https://www.theswisspharmacy.com/product_info.php?info=p9907_Duolin-Rotacaps.html © The Swiss Pharmacy

12. Duolin Rotacaps (Generic Ipratropium Bromide And Levalbuterol Sulphate Rotacaps) Storage Instructions Duolin Rotacaps (Generic Ipratropium Bromide And Levalbuterol Sulphate Rotacaps) have to be stored at controlled room temperature i.e. from 20°C to 25°C (68°F to 77°F) with excursions permitted between 15° to 30°C (59° to 86°F). Keep this as well as all other medicines away from children and pets. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9907_Duolin-Rotacaps.html https://www.theswisspharmacy.com/product_info.php?info=p9907_Duolin-Rotacaps.html © The Swiss Pharmacy

13. Duolin Rotacaps (Generic Ipratropium Bromide And Levalbuterol Sulphate Rotacaps) Warnings Paradoxical Bronchospasm: Discontinue Duolin Rotacaps immediately and treat with alternative therapy if paradoxical bronchospasm occurs. Deterioration of Asthma: Asthma may deteriorate acutely over a period of hours or chronically over several days or longer. If the patient needs more doses of Levosalbutamol (Levalbuterol) than usual, this may be a marker of destabilization of asthma and requires re-evaluation of the patient and treatment regimen. Use of Anti-Inflammatory Agents: The use of a beta-adrenergic agonist alone may not be adequate to control asthma in many patients. Early consideration should be given to adding anti- inflammatory agents, e.g., corticosteroids, to the therapeutic regimen. Patients with cardiovascular system disorders: Like other beta-adrenergic agonists, the Levosalbutamol sulphate contained in Duolin Rotacaps can produce clinically significant cardiovascular effects in some patients, as measured by pulse rate, blood pressure and/or symptoms. Use with caution because of beta-adrenergic stimulation. © The Swiss Pharmacy

14. Duolin Rotacaps (Generic Ipratropium Bromide And Levalbuterol Sulphate Rotacaps) Warnings Ocular effects: Advise patients to avoid spraying into eyes and to contact a physician if blurred vision, halos, or other visual disturbances occur. Monitor patients with narrow-angle glaucoma. Do Not Exceed Recommended Dose: Fatalities have been reported in association with excessive use of inhaled sympathomimetic drugs in patients with asthma. The exact cause of death is unknown, but cardiac arrest following an unexpected development of a severe acute asthmatic crisis and subsequent hypoxia is suspected. Immediate Hypersensitivity Reactions: Immediate hypersensitivity reactions may occur after administration of Ipratropium Bromide or racemic Salbutamol (Albuterol), as demonstrated by rare cases of urticaria, angioedema, rash, bronchospasm, anaphylaxis, and oropharyngeal edema. In case such a reaction occurs, Duolin Rotacaps must be stopped at once and alternative treatment should be considered. © The Swiss Pharmacy

15. Duolin Rotacaps (Generic Ipratropium Bromide And Levalbuterol Sulphate Rotacaps) Warnings Urinary retention: Use with caution in patients with prostatic hyperplasia or bladder-neck obstruction Coexisting conditions: Levalbuterol (Levosalbutamol), like all sympathomimetic amines, should be used with caution in patients with cardiovascular disorders, especially coronary insufficiency, hypertension, and cardiac arrhythmias; in patients with convulsive disorders, hyperthyroidism, or diabetes mellitus; and in patients who are unusually responsive to sympathomimetic amines. Ipratropium Bromide: Ipratropium bromide is a bronchodilator for the maintenance treatment of bronchospasm associated with COPD and is not indicated for the initial treatment of acute episodes of bronchospasm, where rescue therapy is required for rapid response. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9907_Duolin-Rotacaps.html https://www.theswisspharmacy.com/product_info.php?info=p9907_Duolin-Rotacaps.html © The Swiss Pharmacy

16. Duolin Rotacaps (Generic Ipratropium Bromide And Levalbuterol Sulphate Rotacaps) Possible Side Effects Use of Levalbuterol (Levosalbutamol) may be associated with the following serious side effects: Paradoxical bronchospasm, Cardiovascular effects, Immediate hypersensitivity reactions and Hypokalemia. Following side effects were observed in 2% or more of the patients receiving Levalbuterol inhalation or racemic Albuterol and more frequently than in patients receiving placebo during placebo- controlled trial in patients with asthma 12 years of age and older: Allergic reaction, Flu syndrome, Accidental injury, Pain, Back pain, Tachycardia, Migraine, Dyspepsia, Leg cramps, Dizziness, Hypertonia, Nervousness, Tremor, Anxiety, Cough increased, Infection viral, Rhinitis, Sinusitis and Turbinate edema. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9907_Duolin-Rotacaps.html https://www.theswisspharmacy.com/product_info.php?info=p9907_Duolin-Rotacaps.html © The Swiss Pharmacy

17. Duolin Rotacaps (Generic Ipratropium Bromide And Levalbuterol Sulphate Rotacaps) Possible Side Effects Ipratropium Bromide inhalation side effects reported by three percent or more patients in the 12-week controlled clinical trials from 12-week active-controlled clinical trials are Headache, Pain, Influenza-like symptoms, Back Pain, Chest Pain, Hypertension/Hypertension Aggravated, Dizziness, Insomnia, Tremor, Nervousness, Mouth Dryness, Nausea, Constipation, Arthritis, Coughing, Dyspnea, Bronchitis, Bronchospasm, Sputum Increased, Respiratory Disorder, Upper Respiratory Tract Infection, Pharyngitis, Rhinitis and Sinusitus. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9907_Duolin-Rotacaps.html https://www.theswisspharmacy.com/product_info.php?info=p9907_Duolin-Rotacaps.html © The Swiss Pharmacy

18. Duolin Rotacaps (Generic Ipratropium Bromide And Levalbuterol Sulphate Rotacaps) Overdosage Levalbuterol Sulphate: The expected symptoms with overdosage are those of excessive beta-adrenergic receptor stimulation and/or occurrence or exaggeration of any of the symptoms listed under adverse reactions, e.g., seizures, angina, hypertension or hypotension, tachycardia with rates up to 200 beats/minute, arrhythmias, nervousness, headache, tremor, dry mouth, palpitation, nausea, dizziness, fatigue, malaise, and sleeplessness. Hypokalemia may also occur. As with all sympathomimetic medications, cardiac arrest and, even, death may be associated with the abuse of Levalbuterol (Levosalbutamol). Ipratropium Bromide: Dose of Ipratropium Bromide up to 1.2 mg (60 puffs) have been administered by inhalation without the appearance of serious systemic anticholinergic effects. Minor systemic manifestations of anticholinergic action, including dry mouth, visual accommodation disorder and increase of heart rate may occur. © The Swiss Pharmacy

19. Duolin Rotacaps (Generic Ipratropium Bromide And Levalbuterol Sulphate Rotacaps) Treatment of Duolin Rotacaps Overdosage Levalbuterol Sulphate: Treatment consists of discontinuation of Levalbuterol Sulphate (Levosalbutamol) together with appropriate symptomatic therapy. The judicious use of a cardioselective beta-receptor blocker may be considered, bearing in mind that such medication can produce bronchospasm. There is insufficient evidence to determine if dialysis is beneficial in treating overdosage of Levalbuterol. Ipratropium Bromide: Should signs of serious anticholinergic toxicity appear, cholinesterase inhibitors may be considered. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9907_Duolin-Rotacaps.html https://www.theswisspharmacy.com/product_info.php?info=p9907_Duolin-Rotacaps.html © The Swiss Pharmacy

20. Duolin Rotacaps (Generic Ipratropium Bromide And Levalbuterol Sulphate Rotacaps) Duolin Rotacaps During Pregnancy Ipratropium Bromide and Levalbuterol Sulphate Rotacaps (Duolin Rotacaps) has been classified by the US FDA as Pregnancy Category C. There are no adequate and well-controlled studies of Ipratropium Bromide and Levalbuterol Sulphate combination Rotacaps (Duolin Rotacaps) in pregnant women. Because animal reproduction studies are not always predictive of human response, Duolin Rotacaps should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9907_Duolin-Rotacaps.html https://www.theswisspharmacy.com/product_info.php?info=p9907_Duolin-Rotacaps.html © The Swiss Pharmacy

21. Duolin Rotacaps (Generic Ipratropium Bromide And Levalbuterol Sulphate Rotacaps) Duolin Rotacaps Duolin Rotacaps (Generic Ipratropium And Levalbuterol Rotacaps) are manufactured by Cipla Limited, India. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9907_Duolin-Rotacaps.html https://www.theswisspharmacy.com/product_info.php?info=p9907_Duolin-Rotacaps.html © The Swiss Pharmacy