Lasix Tablets (Generic Furosemide Tablets)

1. Lasix Tablets (Generic Furosemide Tablets) © The Swiss Pharmacy

2. Lasix Tablets (Generic Furosemide Tablets) Lasix (Generic Furosemide Tablets) is used in adults and pediatric patients for the treatment of edema and in adults for the treatment of hypertension alone or in combination with other antihypertensive agents. Furosemide tablets are used in adults and pediatric patients for the treatment of edema associated with congestive heart failure, cirrhosis of the liver, and renal disease, including the nephrotic syndrome. Oral Furosemide (Frusemide) could be used in adults for the treatment of hypertension alone or in combination with other antihypertensive agents. © The Swiss Pharmacy

3. Lasix Tablets (Generic Furosemide Tablets) Lasix Tablets are manufactured by Sanofi India Limited in the strength of 40 mg. © The Swiss Pharmacy

4. Lasix Tablets (Generic Furosemide Tablets) Chemical Structure © The Swiss Pharmacy

5. Lasix Tablets (Generic Furosemide Tablets) The active ingredient contained in Lasix tablets is Furosemide (Frusemide) . Each Lasix tablet contains 40 mg of Furosemide (Frusemide). © The Swiss Pharmacy

6. Lasix Tablets (Generic Furosemide Tablets) Uses of Lasix 40 mg tablets: Furosemide (Frusemide) belongs to a group of medicines called loop diuretics (also known as water pills). Furosemide (Lasix Tablets) is given to help treat fluid retention (edema) and swelling that is caused by congestive heart failure, liver disease, kidney disease, or other medical conditions. It works by acting on the kidneys to increase the flow of urine. It is also used for the treatment of peripheral oedema due to mechanical obstruction, venous insufficiency, mild to moderate hypertension. Furosemide is also used alone or together with other medicines to treat high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9564_Lasix-Pills.html https://www.theswisspharmacy.com/product_info.php?info=p9564_Lasix-Pills.html © The Swiss Pharmacy

7. Lasix Tablets (Generic Furosemide Tablets) Uses of Lasix 40 mg tablets: This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled. Hypertensive patients who cannot be adequately controlled with thiazides will probably also not be adequately controlled with Lasix alone. Lasix is particularly useful when an agent with greater diuretic potential than that of those commonly employed is desired. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9564_Lasix-Pills.html https://www.theswisspharmacy.com/product_info.php?info=p9564_Lasix-Pills.html © The Swiss Pharmacy

8. Lasix Tablets (Generic Furosemide Tablets) Recommended Adult Dosage The recommended dose of Lasix Tablets Tablets) is given below: Treatment of Edema in Adults: Treatment of Edema in Adults: The usual initial dose of Lasix (Furosemide tablets) is 20 to 80 mg given as a single dose. Ordinarily a prompt diuresis ensues. If needed, the same dose can be administered 6 to 8 hours later or the dose may be increased. The dose may be raised by 20 or 40 mg and given not sooner than 6 to 8 hours after the previous dose until the desired diuretic effect has been obtained. The individually determined single dose should then be given once or twice daily (e.g., at 8 am and 2 pm). The dose of Lasix tablets may be carefully titrated up to 600 mg/day in patients with clinically severe edematous states. Lasix Tablets (Generic Furosemide URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9564_Lasix-Pills.html https://www.theswisspharmacy.com/product_info.php?info=p9564_Lasix-Pills.html © The Swiss Pharmacy

9. Lasix Tablets (Generic Furosemide Tablets) Recommended Adult Dosage Edema may be most efficiently and safely mobilized by giving Furosemide (Frusemide) on 2 to 4 consecutive days each week. When doses exceeding 80 mg/day are given for prolonged periods, careful clinical observation and laboratory monitoring are particularly advisable. Therapy should be individualized according to patient response to gain maximal therapeutic response and to determine the minimal dose needed to maintain that response. Treatment of Edema in Geriatric patients: Treatment of Edema in Geriatric patients: In general, dose selection for the elderly patient should be cautious, usually starting at the low end of the dosing range. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9564_Lasix-Pills.html https://www.theswisspharmacy.com/product_info.php?info=p9564_Lasix-Pills.html © The Swiss Pharmacy

10. Lasix Tablets (Generic Furosemide Tablets) Recommended Pediatric Dosage Treatment of Edema in Pediatric Patients: Treatment of Edema in Pediatric Patients: The usual initial dose of oral Furosemide (Lasix) in pediatric patients is 2 mg/kg body weight, given as a single dose. If the diuretic response is not satisfactory after the initial dose, dosage may be increased by 1 or 2 mg/kg no sooner than 6 to 8 hours after the previous dose. Doses greater than 6 mg/kg body weight are not recommended. For maintenance therapy in pediatric patients, the dose should be adjusted to the minimum effective level. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9564_Lasix-Pills.html https://www.theswisspharmacy.com/product_info.php?info=p9564_Lasix-Pills.html © The Swiss Pharmacy

11. Lasix Tablets (Generic Furosemide Tablets) Recommended Adult Dosage Treatment of Hypertension: Treatment of Hypertension: Therapy should be individualized according to the patient’s response to gain maximal therapeutic response and to determine the minimal dose needed to maintain the therapeutic response. Treatment of Hypertension in Adult Patients: Treatment of Hypertension in Adult Patients: The usual initial dose of Lasix (Furosemide tablets) for hypertension is 80 mg, usually divided into 40 mg twice a day. Dosage should then be adjusted according to response. If response is not satisfactory, add other antihypertensive agents. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9564_Lasix-Pills.html https://www.theswisspharmacy.com/product_info.php?info=p9564_Lasix-Pills.html © The Swiss Pharmacy

12. Lasix Tablets (Generic Furosemide Tablets) Recommended Adult Dosage Changes in blood pressure must be carefully monitored when Furosemide is used with other antihypertensive drugs, especially during initial therapy. To prevent excessive drop in blood pressure, the dosage of other agents should be reduced by at least 50 percent when Furosemide (Frusemide) is added to the regimen. Treatment of Hypertension in Geriatric Patients: In general, dose selection and dose adjustment for the elderly patient should be cautious, usually starting at the low end of the dosing range. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9564_Lasix-Pills.html https://www.theswisspharmacy.com/product_info.php?info=p9564_Lasix-Pills.html © The Swiss Pharmacy

13. Lasix Tablets (Generic Furosemide Tablets) Contraindications ➔Lasix is contraindicated in patients with a known hypersensitivity to Furosemide (Frusemide) or any component of the tablet. ➔Administration of Lasix is contraindicated in patients with anuria. ➔Patients allergic to Sulfonamides (e.g. Sulfonamide antibiotics or Sulfonylureas) may show cross-sensitivity to Lasix. ➔Hypovolaemia and dehydration (with or without accompanying hypotension) ➔Severe hypokalaemia: severe hyponatraemia. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9564_Lasix-Pills.html https://www.theswisspharmacy.com/product_info.php?info=p9564_Lasix-Pills.html © The Swiss Pharmacy

14. Lasix Tablets (Generic Furosemide Tablets) Contraindications ➔Comatose or pre-comatose states associated with hepatic cirrhosis. ➔Impaired renal function with a creatinine clearance below 30ml/min per 1.73 m2 body surface area ➔Addison's disease. ➔Digitalis intoxication. ➔Concomitant potassium supplements or potassium sparing diuretics. ➔Porphyria ➔Breast-feeding women URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9564_Lasix-Pills.html https://www.theswisspharmacy.com/product_info.php?info=p9564_Lasix-Pills.html © The Swiss Pharmacy

15. Lasix Tablets (Generic Furosemide Tablets) Storage Instructions Lasix Tablets (Generic Furosemide Tablets) have to be stored at controlled room temperature i.e. from 20°C to 25°C (68°F to 77°F) with excursions permitted between 15° to 30°C (59° to 86°F). Keep this as well as all other medicines away from children and pets. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9564_Lasix-Pills.html https://www.theswisspharmacy.com/product_info.php?info=p9564_Lasix-Pills.html © The Swiss Pharmacy

16. Lasix Tablets (Generic Furosemide Tablets) Warnings In patients with hepatic cirrhosis and ascites, Lasix therapy is best initiated in the hospital. In hepatic coma and in states of electrolyte depletion, therapy should not be instituted until the basic condition is improved. Sudden alterations of fluid and electrolyte balance in patients with cirrhosis may precipitate hepatic coma; therefore, strict observation is necessary during the period of diuresis. If increasing azotemia and oliguria occur during treatment of severe progressive renal disease, Lasix should be discontinued. Cases of tinnitus and reversible or irreversible hearing impairment and deafness have been reported. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9564_Lasix-Pills.html https://www.theswisspharmacy.com/product_info.php?info=p9564_Lasix-Pills.html © The Swiss Pharmacy

17. Lasix Tablets (Generic Furosemide Tablets) Warnings Cases of tinnitus and reversible or irreversible hearing impairment have been reported. Usually, reports indicate that Furosemide (Lasix Tablets) ototoxicity is associated with rapid injection, severe renal impairment, doses exceeding several times the usual recommended dose, or concomitant therapy with aminoglycoside antibiotics, ethacrynic acid, or other ototoxic drugs. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9564_Lasix-Pills.html https://www.theswisspharmacy.com/product_info.php?info=p9564_Lasix-Pills.html © The Swiss Pharmacy

18. Lasix Tablets (Generic Furosemide Tablets) Effects On Ability To Drive And Use Machines Reduced mental alertness, dizziness and blurred vision have been reported, particularly at the start of treatment, with dose changes and in combination with alcohol. Patients should be advised that if affected, they should not drive, operate machinery or take part in activities where these effects could put themselves or others at risk. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9564_Lasix-Pills.html https://www.theswisspharmacy.com/product_info.php?info=p9564_Lasix-Pills.html © The Swiss Pharmacy

19. Lasix Tablets (Generic Furosemide Tablets) Possible Side Effects Lasix (Furosemide Tablets) side effects are listed below. Side effects are categorized below by organ system and listed by decreasing severity. Gastrointestinal System Reactions: Pancreatitis, jaundice (intrahepatic cholestatic jaundice), anorexia, oral and gastric irritation, cramping, diarrhea, constipation, nausea, vomiting. Systemic Hypersensitivity Reactions: Systemic vasculitis, interstitial nephritis, necrotizing angiitis Central Nervous System Reactions: Tinnitus and hearing loss, paresthesias, vertigo, dizziness, headache, blurred vision, xanthopsi. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9564_Lasix-Pills.html https://www.theswisspharmacy.com/product_info.php?info=p9564_Lasix-Pills.html © The Swiss Pharmacy

20. Lasix Tablets (Generic Furosemide Tablets) Possible Side Effects Hematologic Reactions: Aplastic anemia (rare), thrombocytopenia, agranulocytosis (rare), hemolytic anemia, leukopenia, anemia Dermatologic-Hypersensitivity Reactions: Exfoliative dermatitis, erythema multiforme, purpura, photosensitivity, urticaria, rash, pruritus Cardiovascular Reaction: Orthostatic hypotension may occur and be aggravated by alcohol, barbiturates or narcotics. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9564_Lasix-Pills.html https://www.theswisspharmacy.com/product_info.php?info=p9564_Lasix-Pills.html © The Swiss Pharmacy

21. Lasix Tablets (Generic Furosemide Tablets) Possible Side Effects Other Reactions: Hyperglycemia, glycosuria, hyperuricemia, muscle spasm, weakness, restlessness, urinary bladder spasm, thrombophlebitis, fever Whenever side effects are moderate or severe, furosemide dosage should be reduced or therapy withdrawn. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9564_Lasix-Pills.html https://www.theswisspharmacy.com/product_info.php?info=p9564_Lasix-Pills.html © The Swiss Pharmacy

22. Lasix Tablets (Generic Furosemide Tablets) Lasix Tablets Overdosage The principal signs and symptoms of overdose with Lasix (Furosemide Tablets) are dehydration, blood volume reduction, hypotension, electrolyte imbalance, hypokalemia and hypochloremic alkalosis, and are extensions of its diuretic action. The acute toxicity of furosemide has been determined in mice, rats and dogs. In all three, the oral LD50 exceeded 1000 mg/kg body weight, while the intravenous LD50 ranged from 300 to 680 mg/kg. The acute intragastric toxicity in neonatal rats is 7 to 10 times that of adult rats. The concentration of Furosemide in biological fluids associated with toxicity or death is not known. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9564_Lasix-Pills.html https://www.theswisspharmacy.com/product_info.php?info=p9564_Lasix-Pills.html © The Swiss Pharmacy

23. Lasix Tablets (Generic Furosemide Tablets) Treatment of Lasix Tablets Overdosage Treatment of Lasix (Generic Furosemide Tablets) overdosage is supportive and consists of replacement of excessive fluid and electrolyte losses. Serum electrolytes, carbon dioxide level and blood pressure should be determined frequently. Adequate drainage must be assured in patients with urinary bladder outlet obstruction (such as prostatic hypertrophy). Hemodialysis does not accelerate Furosemide (Frusemide) elimination. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9564_Lasix-Pills.html https://www.theswisspharmacy.com/product_info.php?info=p9564_Lasix-Pills.html © The Swiss Pharmacy

24. Lasix Tablets (Generic Furosemide Tablets) Lasix Tablets During Pregnancy Furosemide (Frusemide) (Lasix Tablets) has been classified by the US FDA as Pregnancy Category C. Lasix must not be given during pregnancy unless there are compelling medical reasons. Treatment during pregnancy requires monitoring of foetal growth. Thiazides, related diuretics and loop diuretics enter the foetal circulation and may cause electrolyte disturbances. Furosemide caused unexplained maternal deaths and abortions in the rabbit at the lowest dose of 25 mg/kg (two times the maximal recommended human dose of 600 mg/day). In another study, a dose of 50 mg/kg (four times the maximal recommended human dose of 600 mg/day) also caused maternal deaths and abortions when administered to rabbits between Days 12 and 17 of gestation. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9564_Lasix-Pills.html https://www.theswisspharmacy.com/product_info.php?info=p9564_Lasix-Pills.html © The Swiss Pharmacy

25. Lasix Tablets (Generic Furosemide Tablets) Lasix Tablets During Pregnancy Neonatal thrombocytopaenia has been reported with Thiazides and related diuretics. Loop diuretics, like Furosemide (Frusemide) and Bumetanide, are probably also associated with this risk. During the latter part of pregnancy, products of this type should only be given on sound indications, and then in the lowest effective dose. In pregnancy, Furosemide (Lasix Tablets) must only be used in patients with a marked reduction in glomerular filtration. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9564_Lasix-Pills.html https://www.theswisspharmacy.com/product_info.php?info=p9564_Lasix-Pills.html © The Swiss Pharmacy

26. Lasix Tablets (Generic Furosemide Tablets) Lasix Tablets Lasix Tablets (Generic Furosemide Tablets) are manufactured by Sanofi India Limited. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9564_Lasix-Pills.html https://www.theswisspharmacy.com/product_info.php?info=p9564_Lasix-Pills.html © The Swiss Pharmacy