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Green Chemistry as a tool to prevent Pharmaceutical Hazards and Pollution. Dr. Gannu Praveen Kumar M. Pharm., PhD Professor and Principal Department of Pharmaceutics Sahasra Institute of Pharmaceutical Sciences. CDSCO. Industrial Chemistry. Chemical Industry Output.

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  1. Green Chemistry as a tool to prevent Pharmaceutical Hazards and Pollution Dr. Gannu Praveen Kumar M. Pharm., PhD Professor and Principal Department of Pharmaceutics Sahasra Institute of Pharmaceutical Sciences CDSCO

  2. Industrial Chemistry

  3. Chemical Industry Output

  4. Chemical Industry Output

  5. Growing incidence of environmental accidents

  6. E-Factors across the chemical Industry Mass Intensity = mass of all materials used excluding water/mass of product kg (kg product) Solvent Intensity = mass of all solvent used excluding water/mass of product k g (kg product) % Solvent Intensity = mass of all solvent/mass intensity kg (kg product) Water Intensity = mass of all water used/mass of product = kg (kg product) E factor = Total mass of waste produced/Total mass of product produced

  7. Solvent usage for APIs Synthesis

  8. Green Chemistry • Green chemistry is the design of chemical products and processes that reduce or eliminate the use and generation of hazardous substances. • Application: to advance the implementation of green chemistry and engineering principles into all aspects of the chemical enterprise • Education and Research • Education • Industrial Implementation

  9. Green Chemistry = Pharmaceutical Hazard & Pollution Free • “Green chemistry is the science that introduces new substances into the world and we have a responsibility for their impact in the world.”

  10. Fundamentals of Green Chemistry • Increase awareness and understanding of green chemistry principles, alternatives, practices and benefits. • Integrate the principles of Green Chemistry & Green Engineering into the curricula. • Equip chemists to meet tomorrow’s scientific challenges. • Risk = f(Hazard*Exposure)

  11. Principles of Green Chemistry

  12. Green Chemistry Patents

  13. Number of publications

  14. Key Factors Driving Adoption of Green Chemistry

  15. Sustainable Business Processes

  16. Rowan Solvent Greeness Scoring Index Weighted Solvent Greenness Index Solvent = (OSI10⋅solvent ) (Masssolvent) Total Process Greenness Index =Σ Weighted Solvent Greenness Indexsolvent • Inhalation Toxicity − Threshold Limit Value ( TLV ) • Ingestion Toxicity • Biodegradation • Carcinogenicity • Half – Life • Global Warming Potential

  17. Greenness scores for commonly used solvents

  18. Solvent usage in the development of Sildenafil

  19. Waste generation per kilogram of Sitagliptin produced

  20. Dichloromethane use at small molecule discovery sites

  21. Importance of Green Chemistry in Nanotechnology In recent years, the development of efficient green chemistry methods for synthesis of nanoparticles has become a major focus of researchers. An eco-friendly technique for production of well-characterized nanoparticles. Production of metal nanoparticles using organisms ( living or dead) Plants seem to be the best candidates and they are suitable for large- scale biosynthesis of nanoparticles. Nanoparticles produced by plants are more stable and the rate of synthesis is faster than in the case of microorganisms.

  22. Life-Cycle of Nanomaterials

  23. Manufacturing methods used in nanoparticle synthesis

  24. Metallic Nanoparticles

  25. Green Synthesis of Silver Nanoparticles

  26. Surface Modification of Nanoparticles

  27. Metallic Nanoparticles

  28. Magnetic Nanoparticles

  29. Separation of magnetic colloidal carriers

  30. Applications

  31. Green Chemistry in Pharmaceutical Industry

  32. Green Pharmaceutical Industry Design

  33. Conclusion • The Unique Green Chemistry Applications: • Non-toxic manufacture of metallic nanoparticles • Solvent Consumption Reduction • Safer Environment • Cost Reduction

  34. Thank You

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