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Supplementary Figure 1. Alignement by Clustalw 1.83 of L proteins from HBVs infecting a wide range of animals. Cysteine residues are highlighted in red. preS1.

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  1. Supplementary Figure 1. Alignement by Clustalw 1.83 of L proteins from HBVs infecting a wide range of animals. Cysteine residues are highlighted in red. preS1 D12980-HUMAN MGGWSSKPRQG-------------MGTNLSVPNPLGFFPDHQLDPAFGANSNNPDWD---FNPNKDH-WP--DGIKVGAGDFGPGFTPPHGGLLGWSPQAQGIL---TTVPAA------- M12906-HUMAN MGGWSSKPRQG-------------MGTNLSVPNPLGFFPDHQLDPAFGANSNNPDWD---FNPNKDH-WP--EAIKVGAGDFGPGFTPPHGGLLGWSPQAQGIL---TTVPAA------- AAL84829-GIBBON ------------------------MGQNHSVTNPLGFFPDHQLDPLFRANSNNPDWD---FNPNKDN-WP--DATKVGVGAFGPGFTPPHGGLLGWSPQAQGIL---TTLPAA------- AAG4196-CHIMPANZEE ------------------------MGQNLSTSNPLGFFPEHQLDPAFKANTNNPDWD---FNPNKDN-WP--DANKVGAGAFGPGLTPPHGGLLGWSPQAQGIL---TTLPIN------- BAB12583-CHIMPANZEE MGQQLSWTIPLE------------WGKNLSTSNPLGFFPEHQLDPAFKANTNNPDWD---FNPNKDN-WP--TANEVGAGAFGPGLTPPHGGLLGWSPQAQGKL---ITMPAN------- D00220-HUMAN ------------------------MGQNLSTSNPLGFFPEHQLDPAFKANTNNPDWD---FNPKKDY-WP--EATKVGAGAFGPGFTPPHGGLLGLSPQAQGIL---TTLPAN------- X77309-HUMAN ------------------------MGQNLSTSNPLGFFPDHQLDPAFRANTANPDWD---FNPNKDT-WP--DANKVGAGAFGLGFTPPHGGLLGWSPQAQGIL---QTLPAN------- M32138-HUMAN ------------------------MGQNLSTSNPLGFFPDHQLDPAFRANTANPDWD---FNPNKDS-WP--DANKVGAGAFGLGFTPPHGGLLGWSPQAQGIL---QTLPAN------- AF193864-ORANG-UTAN ------------------------MGQNLSVSNPLGFFPEHQLDPLFRANTNNPDWD---FNPNKDT-WP--EATKVGVGAFGPGFTPPHGGLLGWSPQAQGVT---TILPAV------- AF193863-ORANG-UTAN ------------------------MGQNLSVTNPLGFFPEHQLDPLFRANTNNPDWD---FNPNKDT-WP--EATKVGVGAFGPGFTPPHGGLLGWSPQAQGVT---TILPAV------- AA07456-WOLLY MONKEY ------------------------MGLNQSTFNPLGFFPSHQLDPLFKANAGSADWD---KNPNKDP-WP--QAHDTAVGAFGPGLVPPHGGLLGWSSQAQGLS---VTVPDT------- 86062931-WOODCHUCK MGNNIKVTFNPDKIAAWWPAVGTYYT-TTYPQNQSVFQPGIYQTTSLINPKNQQELDSVLINRYKQIDWNTWQGFPVDQKFSLVSRDPPPKPYINQSAQTFEIKPGPIIVPGIRDIPRGL 8918452-WOODCHUCK MGNNIKVTFNPDKIAAWWPAVGTYYT-TTYPQNQSVFQPGIYQTTSLINPKNQQELDSVLINRYKQIDWNTWQGFPVDQKFSLVSRDPPPKPYINQSAQTFEIKPGPIIVPGIRDIPRGL 88101359-WOODCHUCK MGNNIKVTFNPDKIAAWWPAVGTYYT-TTYPQNQSVFQPGIYQTTSLINPKNQQELDSVLINRYKQIDWNTWQGFPVDQKLPLVSRDPPLKPHINQSAQTFEIKPGPIIVPGIRDIPRGL 84267998-GROUND-SQUIRREL MGNNIKVTFDPNKLAAWWPTVGTYYTPTTTVTNPAIFKPGIYQTTSLKNPKNQQELDAILMTRYKEIDWDNWQGFPVNQRLPVSNNNPPS----GQRAETFEIKSRPIIVPGIRDIPRGI D12980-HUMAN -PPPASTNRQSGRQPTPISPPLRDSHPQ-AMQWNST---TFHQALLDPRVRGLYFPAGGSSSGTVNPVPTTASPISSIFSRTGDPA--PNMESTTSGFLGPLLVLQAGFFLLTRILTIPQ M12906-HUMAN -PPPVSTNRQSGRQPTPISPPLRDSHPQ-AMQWNST---TFHQALLDPRVRGLYFPAGGSSSGTVNPVPTTVSPISSIFSRTGDPA--PNMESTTSGFLGPLLVLQAGFFLLTRILTIPQ AAL84829-GIBBON -PPPASTNRQSGRQATPISPPLRDTHPQ-AMQWNST---VFHQTLQDPRVRGLYFPAGGSSSGTVNPAPTTASHISSIFSRTGDPA--PNMDNITSGFLGPLLVLQAGFFLLTKILTIPQ AAG4196-CHIMPANZEE -PPPASTNRQSGRQPTPHSPPMRDTHPQ-AMHWNST---TFHQALQDPRVRGLYFPVGGSSSGTVNPVLNTASHISSIFSRTGDPA--PNMETITSGFLGPLLVLQAGFFLLTKILTIPQ BAB12583-CHIMPANZEE -PPPASNKRQSGRQPTPLSPPLRETHPQ-AMHWNTT---TFHQDL-----------AGGSSSGTVSPVPNTVSHISSIFSRTGDPA--PNMESITSGFLGPLLVLQAVFFLLTKILTIPQ D00220-HUMAN -PPPASTNRQSGRQPTPLSPPLRDTHPQ-AMQWNST---TFHQALQDPRVRGLYFPAGGSSSGTLNPVPNTASHISSVFSTTGDPA--PNMENITSGFLGPLLVLQAGFFLLTKILTIPQ X77309-HUMAN -PPPASTNRQSGRQPTPLSPPLRNTHPQ-AMQWNST---TFHQTLQDPRVRGLYFPAGGSSSGTVNPVLTTASPLSSIFSRIGDPA--LNMENITSGFLGPLLVLQAGFFLLTRILTIPQ M32138-HUMAN -PPPASTNRQSGRQPTPLSPPLRNTHPQ-AMQWNST---TFHQTLQDPRVRGLYLPAGGSSSGTVNPVPTTVSPISSIFSRIGDPA--LNMENITSGFLGPLLVLQAGFFLLTKILTIPK AF193864-ORANG-UTAN -PPPASTNRQSGRQPTPISPPLRDTHPQ-AMQWNST---VFHQTLQDPRVRGLYFPAGGSSSGTVSPVPTSASPISSIFLKTGDPA--PNMENISSGFLGPLLVLQAGFFLLTKILTIPQ AF193863-ORANG-UTAN -PPPASTNRQSGRRPTPISPPLRDTHPQ-AMQWNST---VFHQALQDPRVRGLYFPAGGSSSGTVSPVPTTASPISSTFLKTGDPA--LNMESISSGFLGPLLVLQAGFFLLTKILTIPQ AA07456-WOLLY MONKEY -PPPPSTNRDKGRKPTPATPPLRDTHPQ-AMTWNTS---SFQSYLQNPKVRGLYFPAGGSTSSIVNPVPTTASTTSSSFSTTGVPV--STMDITSSGFLGPLLALQAVFFLLTKILTMPQ 86062931-WOODCHUCK VPPQTPTNRDQGRKPTPPTPPLRDTHPHLTMKNQTFHLQGFVDGLRDLTTTERQHNAYRDPFTTLSPAVPTVSTILSPPSTTGDPALSPEMSP--SSLLGLLAGLQVVYFLWTKILTIAQ 8918452-WOODCHUCK VPPQTPTNRDQGRKPTPPTPPLRDTHPHLTMKNQTFHLQGFVDGLRDLTTTERQHNAYGDPFTTLSPAVPTVSTILSPPSTTGDPALSPEMSP--SSLLGLLAGLQVVYFLWTKILTIAQ 88101359-WOODCHUCK VPPQTPTNRDQGRKPTPPTPPLRDTHPHLTMKNQTFRLQGFVDGLRDLTTTERYHNAYGDPFTTLSPVVPTVSTILSPPSTTGDPALSPEMSP--SSLLGLLAGLQVVYFLWTKILTIAQ 84267998-GROUND-SQUIRREL VPPQTPSNRDQRRKPTPLTPPLRDTHPHLTMKNQTGHLQGFAEGLRALTTSDHHNSAYGDPFTTLSPVVPTVSTTLSPPLTIGDPVLSTEMSP--SGLLGLLAGLQVVYFLWTKILTIAQ preS2 HBsAg

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