1 / 47

Chapter 5 The Lipids:

Chapter 5 The Lipids:. Triglycerides Phospholipids Sterols. Objectives for Chapter 5. Discuss synthesis, structures, classification, function and metabolism of lipids Identify the dietary sources of the different types of lipids Discuss the role of lipoprotein in transport of lipids

alana-huff
Download Presentation

Chapter 5 The Lipids:

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript


  1. Chapter 5The Lipids: Triglycerides Phospholipids Sterols

  2. Objectives for Chapter 5 Discuss synthesis, structures, classification, function and metabolism of lipids Identify the dietary sources of the different types of lipids Discuss the role of lipoprotein in transport of lipids Describe the relationship of lipids to chronic diseases List current dietary recommendations for lipids and how to implement them.

  3. Lipids • Lipids are a class of nutrients that includes: • Triglycerides (fats and oils) • Phospholipids • Sterols. • Composed of carbon, hydrogen, and oxygen. • Lipids are hydrophobic (insoluble in water) • Include fat soluble vitamins (ADEK) • Provides 9 kcal per gram

  4. Triglycerides • TG (fats and oils) – composed of 3 fatty acids attached to a glycerol • Fatty acid - is a chain of carbon atoms with hydrogen attached that has an acid group (COOH) at one end and a methyl group (CH3) at the other end • Glycerol is an alcohol composed of a three carbon chain

  5. Methyl end Acid end Fig. 5-1, p. 140

  6. TG

  7. Triglycerides • Fats are lipids that are solid at room temperature (70 degrees) • Oils are lipids that are liquid at room temperature (70 degrees) • TGs are 95% of dietary fats • Roles of TGs • Energy reserve when stored • Insulation • Shock protection • Use carbohydrate and protein efficiently

  8. Fatty Acids • Fatty acids Fatty acids vary in carbon chain lengths, degree of unsaturation, and number of double bonds. • Length of the carbon chain • Long-chain fatty acids are found primarily in meat, fish, and vegetable oils. • Medium- and short-chain fatty acids are found in dairy products. • Degree of Saturation- Saturation affects the physical characteristics of the fat and its storage properties • Saturated fatty acids carry the maximum possible number of hydrogen atoms.

  9. Saturated vs. Unsaturated • Saturated - When most of the fatty acids are saturated it is called a saturated fat. Stearic acid, an 18-carbon saturated fatty acid

  10. Saturated vs. Unsaturated • Unsaturated – Unsaturated fatty acids are missing at least 2 hydrogen atoms and have at least one double bond. There are 2 types • Monounsaturated fatty acid (MUFA) Oleic acid, an 18-carbon monounsaturated fatty acid

  11. Saturated vs. Unsaturated • Polyunsaturated fatty acids (PUFA) • lack four or more hydrogen atoms and have at least two or more double bonds. • Linoleic and linolenic acid - Essential Fatty Acids (EFAs) • When most of the fatty acids in a lipid are polyunsaturated it is called a polyunsaturated fat. Linoleic acid, an 18-carbon polyunsaturated fatty acid

  12. Saturated vs. Unsaturated • Locations of the double bonds • Omega3 - linolenic acid - the first double bond is located at the third carbon from the methyl side • Omega 6 - linoleic acid - the first double bond is located at the sixth carbon from the methyl side Linoleic acid, an 18-carbon polyunsaturated fatty acid

  13. Omega-3 and Omega-6 Fatty Acids Compared

  14. Saturated and Unsaturated Fatty Acids Help Shape Foods

  15. Fatty Acids Degree of unsaturation • Firmness • Saturated fats - solid at room temperature. Mostly from animal sources • Polyunsaturated fats - liquid at room temperature. Found in vegetable oil except, cocoa butter, palm oil, palm kernel oil, and coconut oil • Stability • Saturated fat is more resistant to oxidation. • Monounsaturated fat is less susceptible to spoilage. • Polyunsaturated fat spoils most readily.

  16. Essential Fatty Acids Essential Fatty Acids • Linoleic Acid - Omega-6 Family and 18 carbon • They are PUFA, • Can make arachidonic acid—a conditionally essential fatty acid with 20 carbons and 4 double bonds • Supplied by vegetable oils and meats

  17. Essential Fatty Acids • Linolenic Acid and 18 Omega-3 Family • EPA - eicosapentaenoic acid, 20 carbon, 5 double bonds • DHA - docosahexaenoic acid, 22 carbons and 6 double bonds • important for eyes, brain development, and heart disease. • Eicosanoids – omega 3 & 6 • Made from arachidonic acid and EPA • Like hormones but have different effects on different cells • Include prostaglandins, thromboxanes, and leukotrienes • Essential fatty acid deficiencies are rare in the US but my occur in children fed low fat or fat free diet

  18. Essential Fatty Acids

  19. Fatty Acids Hydrogenation – • Hydrogen atoms are added to monounsaturated or polyunsaturated fats • Act more like saturated fats • resistant to oxidation • Prolong shelf life • Becomes solid at room temperature • Trans-Fatty Acids vs. Cis • Naturally, most double bonds are cis, hydrogen next to the double bonds are on the same side. • Trans, hydrogens on opposite side of the carbon. • Trans fatty acids behave like saturated fat in the body.

  20. Cis- and Trans-Fatty Acids Compared

  21. Major Food Sources of Trans Fat for American Adults

  22. Phospholipids Phospholipids • contain glycerol, 2 FAs and a phosphate group with a choline. • A well-known phospholipid is lecithin, made by the liver • Food sources of lecithin include eggs, liver, soybeans, wheat germ and peanuts. • Soluble in both water and fat • Roles of phospholipids • Transport lipids and FSV through Plasma membrane • Used as emulsifiers in food industry

  23. Phospholipids

  24. Sterols • Sterols • cholesterol, vit D, testorone • Multiple-ring structure. • Found in plant and animal foods • Cholesterol is found in animal foods only - meat, eggs, fish, poultry and dairy products

  25. Sterols

  26. Sterols • Roles of sterols • Needed to make bile acids, sex hormones, adrenal hormones and vitamin D • Component of cell membranes • Liver produces 800-1500mg of cholesterol daily • Cholesterol forms deposits in the artery wall causing artherosclerosis.

  27. Fat Digestion • Mouth – • hard fat begin to melt as they reach body temperature • salivary glands - lingual lipase digests short and medium chain fatty acids found in milk. • Stomach— • Lingual lipase breaks down triglycerides to produce diglycerides and fatty acids • gastric lipase breaks down a small amount of fat. • Little fat digestion takes place in the stomach.

  28. Fat Digestion • Small Intestine – • most of the digestion takes place in the small intestine. • Cholecystokinin (CCK) signals gallbladder to release bile. • Pancreatic and intestinal enzymes breaks lipids to monoglycerides and fatty acids. • Phospholipids are broken down as well. • Sterols are absorbed intact as is. • Bile is reabsorbed in the small intestine • Colon or large intestine • Soluble fibers traps some bile and excreting it from the body through the large intestine.

  29. Lipid Absorption • Lipid Absorption • Glycerol and short and medium-chain fatty acids diffuse and are absorbed directly into the bloodstream. • Monoglycerides and long-chain fatty acids form micelles, are absorbed, and are reformed into new triglycerides. • With protein they are transported by chylomicrons

  30. Monoglyceride Micelle Protein Triglyceride Long-chain fatty acids Chylomicron Large lipids such as monoglycerides and long-chain fatty acids combine with bile, forming micelles that are sufficiently water soluble to penetrate the watery solution that bathes the absorptive cells. There the lipid contents of the micelles diffuse into the cells.

  31. Lipid Transport • Lipid transport is made possible by a group of vehicles known as lipoproteins. There 4 lipoproteins • Chylomicrons • Largest of the lipoproteins • Least dense • Get smaller as triglyceride portion is removed by the cells • VLDL (Very-Low-Density Lipoproteins) • Composed primarily of triglycerides • Made by the liver • Transport lipids to the tissues • Get smaller and more dense as triglyceride portion is removed

  32. Lipid Transport 3. LDL (Low-Density Lipoproteins) • Composed primarily of cholesterol • Transport lipids to the tissues 4. HDL (High-Density Lipoproteins) • Composed primarily of protein • Transport cholesterol from the cells to the liver

  33. Chylomicrons: One Type of Lipoprotein

  34. The Various Types of Lipoproteins and Their Composition

  35. Lipid Transport • Health Implications • High LDL is associated with higher risk of heart attack and is known as “bad” cholesterol. • High HDL seems to have a protective effect and is known as “good” cholesterol

  36. Storing Fat as Fat Adipose tissue readily stores fat. Provides twice the energy as carbohydrate and protein 1 lb of body fat = 3,500 cal Lipoprotein lipase (LPL) breaks triglycerides as they pass, directs the parts into the cells to be used for energy or storage. Using Fat for Energy Fat supplies 60% of the body’s ongoing energy needs. lipase inside the adipose cells hydrolyzes triglycerides when needed for energy. Fasting metabolizes fat but needs carbohydrate and protein for complete breakdown. Ketone bodies Storing Fat

  37. Health Effects of Lipids • Normal blood lipid profile • Total cholesterol  200 mg/dL • LDL cholesterol  100 mg/dL • HDL cholesterol  60 mg/dL • Triglycerides  150 mg/dL • Atherosclerosis - Cholesterol accumulates in the arteries • saturated fats raise LDL • Trans fat increase LDL cholesterol and decrease HDL cholesterol • Cholesterol has less effect on blood cholesterol than saturated fat and trans fat.

  38. Atherosclerosis

  39. Health Effects of Lipids • Increasing dietary MUFA & PUFA is the most effective way to prevent heart disease. • omega-3 fats help to reduce risk of heart disease and stroke • Balance omega-6 and omega-3 intakes • Cancer - Fat does not initiate cancer development but may be a promoter once cancer has developed • Obesity- consequence of high fat diet

  40. Recommended Intakes of Fat • DRI and the 2005 Dietary Guidelines recommends fat at 20-35 % of energy intake. • FDA - 10% of energy intake from saturated, 30% of energy intake total fat • 2005 Dietary Guidelines - choose a diet low in saturated fat and cholesterol and moderate in total fat.

  41. Recommended Intakes of Fats • Recommended Intakes of Fat • Daily Values • 65 g fat based on 30% of 2000-kcal diet • 20 g saturated fat based on 10% of 2000-kcal diet • 300 mg cholesterol • USDA Food Guide considers saturated fats discretionary kcalories. • Too little fat can be detrimental to health.

  42. Recommended Intakes of Fat • Linoleic acid AI • 5% - 10% of energy intake • Linolenic acid AI • 0.6 - 1.2% of energy intake

  43. Reducing Fat In Your Diet • Cook with olive oil • Nibble on nuts • Feast on fatty fish, high in omega 3 • But beware of mercury • Limit Fatty Meats, Milk Products, and Tropical Oils • Limit hydrogenated foods

  44. Reducing Fat in Your Diet • Fat replacers • Artificial, ingredients derived from carbohydrate, protein or fat. • Replace fat in foods, but no added kcalories • Olestra is safe but it deceases absorption of fat-soluble vitamins and may cause diarrhea. • Limit Fatty Meats, Milk Products, and Tropical Oils • Limit Hydrogenated Foods • Adopt the Mediterranean diet • Focus on whole grains, potatoes, and pasta, vegetables and legumes, low fat cheeses, yogurt, fruits, fish and seafood, poultry, a few eggs and little meat

  45. Homework Extra credit 5 points: Go to the supermarket and compile a list of 10 foods that contain hydrogenated fat in the ingredient list and document the amount of trans fat listed on the nutrition fact panel

More Related