1 / 8

How do we adapt to high altitude?

Matt Macoul BMCB 658 4/6/2012. How do we adapt to high altitude?. Effects of High Altitudes. Low oxygen pressure Hypoxia Not just from altitude Heart Attack Stroke Affects cellular respiration and more. The Body’s Response. Increase in red blood cells Erythropoietin (EPO)

alena
Download Presentation

How do we adapt to high altitude?

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Matt Macoul BMCB 658 4/6/2012 How do we adapt to high altitude?

  2. Effects of High Altitudes • Low oxygen pressure • Hypoxia • Not just from altitude • Heart Attack • Stroke • Affects cellular respiration and more

  3. The Body’s Response • Increase in red blood cells • Erythropoietin (EPO) • Formation of new capillaries • Vascular Endothelial Growth Factor (VEGF)

  4. Hypoxia Inducible Factors (HIFs) • Hypoxia Inducible Factors (HIFs) • Heterodimeric form • HIFα • HIFβ • Many possible triggers

  5. Summary

  6. Applications & Possibilities • Tumors • Inhibition of HIF may inhibit tumor growth • Anemia • Activation of HIF may help complications of disease

  7. References Hsieh MM, Linde NS, Wynter A, Metzger M, Wong C, et al. (2007) HIF prolyl hydroxylase inhibition results in endogenous erythropoietin induction, erythrocytosis, and modest fetal hemoglobin expression in rhesus macaques. In Blood. 2007;110:2140–2147 Jensen, R., Ragel, B., Whang, K., & Gillespie, D. (2006). Inhibition of hypoxia inducible factor-1alpha (HIF-1alpha) decreases vascular endothelial growth factor (VEGF) secretion and tumor growth in malignant gliomas. In Journal Of Neuro-Oncology, 78(3), 233-247 Peet, D., Hampton-Smith, R. (2007) Hypoxia-inducible factor. In AccessScience. Retrieved from http://www.accessscience.com.libproxy.unh.edu/content.aspx?searchStr=hif&id=YB071150

More Related