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Oxidation… not like burning a marshmallow. Rather, stepwise release of energy.

Oxidation… not like burning a marshmallow. Rather, stepwise release of energy. Two primary forms of energy are: Nucleotide triphosphate (e.g. ATP, GTP) Reducing power (NADH, NADPH). Two ways to make them: Through glycolysis (cytosol) Oxidative phosphorylation (mitochondria).

alika-tillman
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Oxidation… not like burning a marshmallow. Rather, stepwise release of energy.

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  1. Oxidation… not like burning a marshmallow. Rather, stepwise release of energy.

  2. Two primary forms of energy are: Nucleotide triphosphate (e.g. ATP, GTP) Reducing power (NADH, NADPH) Two ways to make them: Through glycolysis (cytosol) Oxidative phosphorylation (mitochondria) The driving force for oxidative phosphorylation is the movement of ions (from last two lectures)

  3. Chemiosmotic coupling and the PMF

  4. Gut or lysozome Cytosol Matrix Pyruvate Aceyl CoA NADH, FADH2, GTP First, the entire process then I’ll break it down into its parts.

  5. Stage 2 Oxidation, but not Molecular O2 Some ATP but inefficient. Understand but don’t memorize 10 rxns, panel 13-1

  6. What happens when molecular oxygen is absent?

  7. If fermentation does not occur (i.e. oxygen is present), pyruvate is used for oxidative phosphorylation … in the mitochondrion.

  8. Let’s get oriented:

  9. Pyruvate is rapidly taken up…. in the mitochondrial matrix:

  10. In the matrix, FA are converted to acyl CoA

  11. The Kreb Cycle reduced to its simplest form. This occurs w/ soluble enzymes in the matrix

  12. Hans Adolf KrebsFritz Albert Lipmann Interested? Check out “How we know”

  13. OVERVIEW….

  14. Back to the mitochondrion… ~ same as cytosol Impermeable, cristae, Large surface, electron transport Porin, 5kDa exclusion

  15. Overview of matrix and some inner membrane reactions.

  16. Chemistry 11 refresher: Reduced means received An electron Oxidized means lost an electron Oxygen readily receives electrons “things are oxidized by oxygen” Negative means good electron donor pair ~ energy of ADP +P{ Positive voltage means good electron acceptor

  17. Cyanide and CO block cytochrome c oxidase

  18. Mitochondria DV is more important Chloroplasts DpH is more important

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