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Amarjit Mishrau00a0and his research team that the mitochondrial metabolite itaconate, a TCA cycle intermediate, alters dendritic cells effector activities and affects the development of HDM-induced allergic asthma in mice.<br>
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Metabolic Reprogramming Drives Allergic Asthma and Inflammation Recent Advances by Amarjit Mishra Amarjit Mishra Assistant Professor at Auburn University has made an effort to draw attention to the part played by Pyruvate Kinase M2 in Th2 inflammation brought on by allergens. Also, he has done a fantastic job of showing how Mitochondrial Irg1 and Itaconate jointly control Th2 inflammation.
Role of Glycolytic Enzyme Pyruvate Kinase M2 According to one of Amarjit Mishra’s investigations, antigen-presenting dendritic cells that depends on immature mitochondrial oxidative phosphorylation and are controlled by AMPK signalling are the ones that start allergen-induced Th2 inflammation.
Role of Mitochondrial Irg1 and Itaconate in Th2 Inflammation Further, it has recently been demonstrated by Amarjit Mishra and his research team that the mitochondrial metabolite itaconate, a TCA cycle intermediate, alters dendritic cells effector activities and affects the development of HDM-induced allergic asthma in mice.
The above results of some of the pioneering works by Amarjit Mishra’s lab at Auburn University suggests the key role played by scientists in enhancing the knowledge about the interlink between allergic asthma and Th2 inflammation. Source:-https://bunchway.com/education/metabolic-reprogramming-drives-allergic-asthma-and-inflammation-recent-advances-by-amarjit-mishra/
