Diagnosis made

1. Diagnosis made Antenatal Postnatal Consent Consent Cleft team inform national cleft centre and Crane Cleft team inform national cleft centre and Crane Cord blood taken yes no DNA / Cell line Blood taken by phlebotomy at time of primary closure Blood taken from parents by phlebotomy at outpatient clinic Blood taken from parents by phlebotomy at outpatient clinic yes no yes no DNA / Cell line no yes Saliva buccal cell DNA collection DNA / Cell line Blood taken from child by phlebotomy at outpatient clinic Saliva buccal cell DNA collection DNA / Cell line yes no Saliva buccal cell DNA collection DNA / Cell line Blue = DNA from child, Red = DNA from parents