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Hypocalcemia in dairy cattle

Hypocalcemia in dairy cattle. Sophie Rosevear Jess Neal. Tara Hall Alex Doddridge. Introduction. 99% of a cow’s calcium is stored in the skeleton. Calcium is essential for many physiological processes; neuromuscular function, blood clotting and hormonal secretion .

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Hypocalcemia in dairy cattle

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  1. Hypocalcemiaindairy cattle Sophie Rosevear Jess Neal Tara Hall Alex Doddridge

  2. Introduction • 99% of a cow’s calcium is stored in the skeleton. • Calcium is essential for many physiological processes; neuromuscular function, blood clotting and hormonal secretion. • Failure to maintain calcium homeostasis (hypocalcaemia, milk fever, parturient paresis) affects productivity of the cows and profitability of the dairy industry. • Calcium homeostasis is stressed in dairy cattle as their main function is to produce high milk yields. Also, during the transition period the demand for calcium dramatically increases.

  3. Calcium Homeostasis • Cows can only obtain calcium from dietary sourcesand absorb calcium through the epithelial cells of the small intestine. • Calcium is removed from the body through: • Urine • Faeces, and • Milk production. • Plasma calcium levels should be 8.5-10 mg/dL for a healthy adult cow. This is regulated by intestinal and renal absorption, and bone turnover. • Calcium is removed from the body via urine and faeces and is also lost through milk production.

  4. Calcium Homeostasis II • A decline in calcium levels stimulates the parathyroid gland to release parathyroid hormone (PTH). This increases calcium reabsorption from the glomerularfiltrate. • PTH also triggers production of 1 α-hydroxylase which converts circulating vitamin D to 1,25-dihydroxyvitamin D.

  5. Calcium Homeostasis III • When the calcium levels return to normal, the secretion of PTH decreases via a negative feedback loop. • Calcitonin is secreted by the thyroid in response to calcium levels increasing beyond the ‘setpoint’. • Osteocyticosteolysis is stimulated if both the demand for calcium and the PTH levels remain high.

  6. Calcium Homeostasis IIII

  7. Development of hypocalcaemia • Dairy cows: • Lactate for 10 months of the year. • Pregnant from about 3 months into lactaction (3 monthas after last calving). • Calve once a year, 8 weeks into their dry period. • During the ‘dry period’, calcium levels required for foetal growth are quite low compared to the demands of lactation. • The onset of lactation requires a high level of calcium, this can cause an imbalance from the high output of calcium in the colostrums and the influx of calcium to maintain the plasma levels.

  8. Development of hypocalcaemia II • ~50% of adult dairy cows develop subclinical hypocalcaemia within the first few weeks of lactation. • 5-20% of dairy cows each year will not adapt and recover calcium balance. • This is a severe metabolic disease known as milk fever and normally occurs 12-24 hours after parturition, but can occur several weeks before and after. • Prolonged release of PTH increases reabsorption of calcium (intestinal, renal and bone).

  9. Clinical signs and pathology of disease • Initially: • Anorexia • Listlessness • Muscle weakness • Body temperature declines • Sternalrecumbancy

  10. Clinical signs and pathology of disease II • “Crush Syndrome” • If parturient, the birthing process is suspended. • Weak pulse and heart sounds, tachycardia. • Loss of consciousness with body temperature as low as 32°C. • Death can occur within hours without treatment.

  11. Predisposing factors • Age • Breed • Metabolic Alkalosis • Hypomagnesia

  12. Control (Prevention) • The DietryCation-Anion Difference (DCAD) Method • Reduce dietrycations, increase anions  Lowers blood pH • Feed a calcium deficient diet • Decreases plasma calcium • Higher dietry magnesium • Maintains adequate levels of Magnesium in the blood.

  13. Effect of DCAD Source: Horst et al. 2005 (full ref in reference list)

  14. Treatment Treat as early as possible. • Fastest: IV injection of Calcium salts  (commonly Ca borogluconate). • Administer the Ca at a rate of 1 g/min • Subcutaneous injection • Blood flow is often compromised, so absorption is variable • A single subcutaneous site should be limited to 1–1.5 gCa (50–75 mL). • Intramuscular administration • Limited to 0.5–1.0 g Ca/injection site to avoid tissue necrosis. • Oral treatments are not reccomended.

  15. Conclusion • Hypocalcaemia in dairy cows is an economically important disease. • Loss of production • Cost of control • Treatment measures. • It reduces a dairy cow’s productive life. • Prevention is better than cure  complications are difficult to prevent once the clinical signs are present. Future research will bring a greater understanding of the regulatory mechanisms and control of calcium homeostasis in the dairy cow.

  16. References • Bigras-Poulin, M. & Tremblay, A. 1998, ‘An epidemiological study of calcium metabolism in non-paretic postparturient Holstein cows’, Preventive Veterinary Medicine vol. 35, pp. 195-207 • El-Samad, H., Goff, J.P. and Khammash, M. 2002, ‘Calcium homeostasis and parturient hypocalcaemia: An integral feedback perspective’, Journal of Theoretical Biology vol. 214, pp. 17-29 • Goff, J.P. 2008, ‘The monitoring, prevention, and treatment of milk fever and subclinical hypocalcaemia in dairy cows’, The Veterinary Journal vol. 176, pp. 50-57 • Goff, J.P., Reinhardt, T.A. and Horst, R.L. 1991, ‘Enzymes and factors controlling vitamin D metabolism and action in normal and milk fever cows’, Journal of Dairy Science vol. 74, no. 11, pp. 4022-4032 • Goff, J.P., Ruiz, R. and Horst, R.L. 2004, ‘Relative acidifying activity of anionic salts commonly used to prevent milk fever’, Journal of Dairy Science vol. 87, pp. 1245-1255 • Hamali, H. 2008, 'Post estrushypocalcemia in a repeat breeder half-breed holstein cow', Journal of Animal and Veterinary Advances vol. 10, pp. 1301-1304 • Horst, R.L. (1986), ‘Regulation of calcium and phosphorus homeostasis in the dairy cow’, Journal of Dairy Science vol. 69, pp. 604-616 • Horst, R.L., Goff, J.P. and Reinhardt, T.A. 1994, ‘Calcium and vitamin D metabolism in the dairy cow’,Journal of Dairy Science vol. 77, pp. 1936-1951 • Horst, R.L., Goff, J.P. and Reinhardt, T.A. 2005, ‘Adapting to the transition between gestation and lactation: Differences between rat, human and dairy cow’, Journal of Mammary Gland Biology and Neoplasia vol. 10, no. 2, pp. 141-156

  17. Kimura, K., Reinhardt, T.A. and Goff, J.P. 2006, ‘Parturition and hypocalcaemia blunts calcium signals in immune cells of dairy cattle’, Journal of Dairy Science vol. 89, pp. 2588-2595 • Lean, I. J., DeGaris, P. J., McNeil, D. M. and Block, E. 2006, 'Hypocalcemia in dairy cows: meta-analysis and dietary cation anion difference theory revised', Journal of Dairy Science vol. 89, pp. 669-684 • Oba, M., Oakley, A.E. and Tremblay, G.F. 2011, ‘Dietary Ca concentration to minimise the risk of hypocalcaemia in dairy cows is affected by the dietary cation-anion difference’, Animal Feed Science and Technology vol. 164, pp. 147-153 • Peacock, M. 2010, ‘Calcium Metabolism in Health and Disease’, Clinical Journal of the American Society of Nephrology vol.5, pp. s23-s30 • Radositis, O.M., Gay, C.C., Hinchcliff, K.W. and Constable, P.D. (2007), 'Veterinary Medicine - A textbook of the diseases of cattle, horses, sheep, pigs and goats,' Saunders Elsevier, worldwide (Sydney) • Reinhardt, T. A., Lippolis, J. D., McCluskey, B. J., Goff, J. P. and Horst, R. L. 2011, 'Prevalence of subclinical hypocalcemia in dairy herds', The Veterinary Journal vol. 188, pp. 122-124 • Ramberg, C.F., Johnson, E.K., Fargo, R.D. and Kronfeld, D.S. 1984, ‘Calcium homeostasis in cows, with special reference to parturient hypocalcaemia’, America Journal of Physiology vol. 246, no. 15, pp. R698-R704 • Schenck, P. A. and Chew, D. J. 2008, 'Hypocalcemia: A Quick Reference', Veterinary Clinic Small Animal vol. 38, pp. 455-458 • Shahzad, M. A. and Mahr-un-Nisa, M. S. 2008, 'Influence of varying dietary cation anion difference on serum minerals, mineral balance and hypocalcemia in Nili Ravi buffaloes', Livestock Science vol. 113, pp. 52-61

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