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Discuss Synthesis of Information from Studies Demonstrate Snippets of Information Synthesis
Combination of Results from two or more studies This step is relevant for Systematic Reviews and Guidelines Literature Synthesis >> New Knowledge
Systematic Reviews Meta Analyses Guidelines Consistency
Frame a Structured Question Conduct Search of the Literature Critically Appraise Individual Research Select and Combine the Results
Narrative Combination Numeric Synthesis
Create Tables of Results From the Results, answer the questions
Meta Analyses Usually done for RCTs to be combined Rules: Check if the studies are homogeneous If homogeneous, provide estimates based on ◦ Random Effects ◦ Fixed Effects
The results or effect sizes are similar If they are not similar or grossly dissimilar then No Point in Summing The Studies Together
The studies are from a “universe” of similar studies The estimate provides a “if a hypothetical study were to be done, then …” Estimates are conservative The Fixed Effects Model tells us “based on _this_ subset of studies ….”
Civljak, M., Sheikh, A., Lf, S., & Car, J. (2012). Internet-based interventions for smoking cessation ( Review ).
Synthesis is the process of combination of different study findings Two Applications are Systematic Review and Guideline Development Synthesis > Adding up the Results Narrative Synthesis is always done (Systematic Review) Numerical Synthesis requires considerations of: Whether homogeneity of effects exist Whether we are interested in fixed or random effects