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Pathogenesis of Hepato-splenic Manifestation of Schistosoma Infection

Pathogenesis of Hepato-splenic Manifestation of Schistosoma Infection. Penetration of intact skin with infective cercariae. Hemodynamic changes. Ova in the portal blood. Portal hypertension. Ova lodge at the presinusoidal sites. Portosystemic collaterals. Splenomegaly.

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Pathogenesis of Hepato-splenic Manifestation of Schistosoma Infection

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  1. Pathogenesis of Hepato-splenicManifestation of Schistosoma Infection

  2. Penetration of intact skin with infective cercariae Hemodynamic changes Ova in the portal blood Portal hypertension Ova lodge at the presinusoidal sites Portosystemic collaterals Splenomegaly Recruitment of host’s inflammatory cells Varices at the lower end of esophagus and other sites GRANULOMA formation Presinusoidal portal blockage Compensatory arterialization Hepatomegaly T-lymphocytes - fibroblast series interaction cytokines (IL-2, IL-4, IL-1, TGF-B) >>> IFN-γ, IL-12 HLA Type I & II genetics Retention of hepatocyte perfusion FIBROSIS Periportal (Symmers’ clay pipe-stem fibrosis) Diffuse Liver function deterioration Ascites, hypoalbuminemia defects in coagulation N liver function tests CIRRHOSIS

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