1 / 12

NSAIDs: Actions and Uses

Introductory Clinical Pharmacology Chapter 18 Nonopioid Analgesics: Nonsteroidal Anti-Inflammatory Drugs. NSAIDs: Actions and Uses. N on- S teroidal A nti- I nflamatory D rugs NSAIDs inhibit two related enzymes:

ashley
Download Presentation

NSAIDs: Actions and Uses

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Introductory Clinical PharmacologyChapter 18Nonopioid Analgesics: Nonsteroidal Anti-Inflammatory Drugs

  2. NSAIDs: Actions and Uses • Non-Steroidal Anti-Inflamatory Drugs • NSAIDs inhibit two related enzymes: • Inhibit activity of cyclooxygenase-1 (COX-1): Enzyme helps to maintain the stomach lining • What do you think a possible side effect of this could be??? • Inhibit activity of cyclooxygenase-2 (COX-2): Enzyme triggers pain and inflammation

  3. Medications to Recognize:NSAIDs: Actions and Uses • Ibuprofen (Advil/Motrin) and naproxen: Block COX-2 produces pain relief; inhibit COX-1 causes adverse reactions, including unwanted GI reactions such as stomach irritation and ulcers • Celecoxib (Celebrex): Inhibits only COX-2; less potential for GI adverse reactions • Used for: Osteoarthritis, rheumatoid arthritis, and other musculoskeletal disorders; mild to moderate pain; primary dysmenorrhea; fever reduction

  4. NSAIDs: Adverse Reactions • Gastrointestinal system reactions • Nausea, vomiting, dyspepsia, diarrhea, constipation, epigastric pain, indigestion, abdominal distress or discomfort, intestinal ulceration, stomatitis

  5. NSAIDs: Contraindications • Hypersensitivity; there is cross-sensitivity if allergic to one NSAID there is increasedrisk of allergic reaction to others; hypersensitivity to aspirin; during third trimester of pregnancy and lactation • Ibuprofen – hypertension, peptic ulceration, or GI bleeding • Celecoxib – allergic to sulfonamides, or history of cardiac disease or stroke

  6. NSAIDs: Precautions • Cautious use: Pregnancy (pregnancy category B

  7. NSAIDs: Interactions • Anticoagulants: Increased risk of bleeding

  8. Nursing Process: Assessment • Preadministration assessment • History: Allergies, GI bleeding, cardiovascular disease, stroke, hypertension, peptic ulceration, impaired hepatic or renal function; if present notify PHCP • Assess and document: Type, onset, intensity, and location of pain • Note if pain different from previous episodes of pain

  9. Nursing Process: Assessment (cont’d) • Ongoing assessment • Monitor: Pain relief; reassess pain rating 30-60 minutes following administration of the drug • Persisting pain: Assess and document severity, location, and intensity; monitor vital signs at least every 4 hours • Assess for decrease in inflammation and mobility in joints • Report: Any adverse reactions (dark stools, prolonged bleeding)

  10. Nursing Process: Implementation • NSAID administered with food, milk, or antacids

  11. Nursing Process: Evaluation • Relief from pain and discomfort; better mobility • Body temperature: Normal • Adverse reactions: Identified, reported, and managed • Patientverbalizes understanding of treatment regimen and adverse effects of the drug

  12. End of Presentation

More Related