1 / 16

Membranes in Biology

Rob Phillips California Institute of Technology. Membranes in Biology. (McMahon). Cells and Their Membranes. Cells and Their Membranes. Lipids. Lipid Bilayers (In Vitro). Hydrophobic tails and polar head groups. Favorable for lipids to spontaneously assemble to form bilayers.

avalley
Download Presentation

Membranes in Biology

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Rob Phillips California Institute of Technology Membranes in Biology (McMahon)

  2. Cells and Their Membranes

  3. Cells and Their Membranes

  4. Lipids

  5. Lipid Bilayers (In Vitro) Hydrophobic tails and polar head groups. Favorable for lipids to spontaneously assemble to form bilayers. (Avanti Polar Lipids) Molecular Continuum

  6. Membranes In Vivo Real biological membranes contain many different lipids & transmembrane proteins!

  7. The Complexity of Real-World Membranes

  8. The Motility of Proteins in Membranes

  9. Membrane Deformation in Biology (McMahon)

  10. Membrane Deformation in Biology (McMahon)

  11. Quantitative Tools for Tomography: Viral Budding as an Example HIV Budding Tomography producing wide range ofimagesof deformed membrane systems. (Dooher et al.) Observed Membrane Deformation During Cell Movement Calculated Deformation of Vesicle Due to Actin Polymerization (Medalia et al.)

  12. Vesicle Transport

  13. Vesicle Transport: Clathrin Coating

  14. Dynamin and Vesicle Fission (McMahon)

  15. Ion Channels and Transient Permeability Channels open in response to a variety of different stimuli. Key mechanisms are voltage gating, ligand binding-induced gating and mechanical tension in the membrane.

  16. Physics of Viral Budding (http://www.aids-info.ch/e_te/aas-e-imm.htm)

More Related