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Systems medicine & COPD

Grazie per aver scelto di utilizzare a scopo didattico questo materiale delle Guidelines 2011 libra. Le ricordiamo che questo materiale è di proprietà dell’autore e fornito come supporto didattico per uso personale. Systems medicine & COPD. Alvar Agustí. Data-free lecture (almost).

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Systems medicine & COPD

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  1. Grazie per aver scelto di utilizzare a scopo didattico questo materiale delle Guidelines 2011 libra.Le ricordiamo che questo materiale è di proprietà dell’autore e fornito come supporto didattico per uso personale.

  2. Systems medicine & COPD Alvar Agustí

  3. Data-free lecture (almost)

  4. Systems medicine: basic hypothesis Galas DJ, Hood L. IBC 1 (6):1-4, 2009 Diseases arises as a consequence of one or more biological networks in the relevant organ that have become disease-perturbed through genetic and/or environmental pathogenic changes.

  5. Barabasi AL. N Engl J Med 357 (4):404-407, 2007

  6. The human disease network Goh et al. PNAS104 (21):8685-8690, 2007

  7. The disease gene network Goh et al. PNAS104 (21):8685-8690, 2007

  8. Goh et al. PNAS104 (21):8685-8690, 2007

  9. Goh et al. PNAS104 (21):8685-8690, 2007

  10. Regan EA et al. COPD 7 (1):32-43, 2010 Vestbo et al. ERJ 31 (4):869-873, 2008 http://www.cancold.ca http://www.cscc.unc.edu/spir/

  11. Airway Disease PRedictingOutcomes through Patient Specific Computational Modelling Unbiased Biomarkersfor the Predictionof Respiratory DiseaseOutcomes Synergy

  12. High throughput technology Bioinformatics

  13. Systems medicine & COPD Pollution Infections Environmental network Diet Temperature • Life-style • Modifiable factors Smoking Allergens COPD Metab Syn. Cancer Osteoporosis Clinical network Myopathty • Clinical phenotypes • Integrated care • Personalized medicine • Guidelines network CVD Innate inmunity Acquired immunity Oxidative stress Biological network Ageing • Intermediate pathophenotypes • Diagnostic biomarkers • Therapeutic targets Repair Bioenergetics GWAS Genetic network Epigenetics • Genetic markers • Risk assessment miRNA miDNA ncRNA Agusti A , Vestbo J AJRCCM 2011

  14. N=30.000.000 individuos (Medicare)

  15. Traditional medicine Reactive = centered around diseases

  16. P4 Medicine P4= centered on health

  17. International Centre for Advanced Respiratory Medicine Thanks for your attentionalvar.agusti@clinic.ub.es

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