Today is Thursday, November 21 st , 2013

In This Lesson: Transcription and Translation (Lesson 2 of 3) Today is Thursday,November 21st, 2013 Pre-Class: Which DNA base(s) is/are purine(s)? Which is/are pyrimidine(s)? Which is/are neither?

Today’s Agenda • Transcription • Translation • Bingo! • The longest protein (and longest “word”) yet known. • Where is this in my book? • Academic: P. 300 and following… • Honors: P. 190 and following…

The Story • It’s the year 1830. • You live in Bucks County, but own a factory in Lancaster County. The factory is waiting for your instructions before they begin producing anything. • How will you tell your factory to begin without going all the way over there yourself? Think of a way with your group and be detailed but efficient.

The Cell’s Version • You: The nucleus • Factory: The ribosome • The Messenger: mRNA • The Message: Gene • The Product: Protein • The Process of Writing and Delivering the Message: Transcription • The Process of the Factory Making Product: Translation

The Big Idea • Today we’re talking about transcription and translation. • Transcription is the process of creating RNA (specifically mRNA). • Translation is using mRNA (and other kinds of RNA) to make proteins. • We’re going to start with transcription.

The Big Idea (or Central Dogma) Transcription Translation NOTE:DNA Replication does not have to happen before transcription. Protein DNA RNA Trait Replication

Just one more… • Transcription takes place where DNA is, obviously. • In which part of the cell does transcription occur? • The nucleus! Whoo! • Translation takes place in the cytoplasm with the help of a ribosome.

The Big Idea (or Central Dogma) Transcription Translation Protein DNA RNA Trait Nucleus Cytoplasm @ Ribosome

But first… • Try numbers 1 and 2 on your Transcriptlate Lab. • Find your group’s DNA strand and record it in line 1 on the worksheet. • Then, in line 2, record the complementary strand. • Remember, A to T, T to A, C to G, G to C.

About RNA… • RNA is another kind of nucleic acid. • Ribonucleic acid. • It is usually single-stranded, DNA is double-stranded. • Instead of having Deoxyribose, it has Ribose. • Instead of having Thymine, it has Uracil.

Mmm, sugar! • Sugar differences: • Deoxyribose is missing an oxygen. http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/P/Pentose.gif

Compare and Contrast • Using these pictures and your notes, organize a T-chart comparing DNA and RNA.

Here’s what I got…

Transcription Specifics • Really, you can think of transcription as the nucleus’s way of sending a message to the ribosome to make protein. • It just needs to transcribe the message into ribosome language first. That language is called mRNA. • mRNA stands for “messenger RNA” – makes sense, huh?

Transcription • Just like in replication, the DNA is unwound, but this time by RNA Polymerase. • RNA nucleotides begin to be added to a new mRNA strand. • This time, not by DNA Polymerase but……………….. • RNA Polymerase again! (the enzyme that does it all) • Difference: Every time the mRNA molecule would have a T, a U for Uracil is placed instead. • Uracil is also a pyrimidine.

P Deoxy-ribose Transcription Deoxy-ribose ---H--- Adenine P P P P P P P P P P P P DNA re-coils mRNA exits nucleus Strands move apart RNA Polymerase makes mRNA RNA Polymerase breaks H-bonds Ribose Ribose Deoxy-ribose Ribose Deoxy-ribose Deoxy-ribose Ribose Ribose Ribose ---H--- Guanine Adenine Cytosine Guanine Uracil Thymine Guanine Uracil Adenine Adenine P Deoxy-ribose ---H--- Thymine

Examples • Board examples • Videos • HHMI • Biologix

Transcription StepsKnow these! • Unzip DNA Helix with RNA Polymerase. • [DNA Replication uses DNA Helicase] • Create strand of mRNA with RNA Polymerase. • [DNA Replication uses DNA Polymerase] • Where you would put a T for Thymine, place a U for Uracil.

Transcriptlate Lab • Now try number 3 on your Transcriptlate Lab. • Remember, use your original strand (printed on your worksheet) and anytime you would put a T, put a U instead.

Sense and Anti-sense Strands • This is confusing! • The antisense strand is the one being transcribed. • The antisense strand is sometimes called the nonsense strand. • The sensestrand is the other one. It looks a lot like the mRNA but has nothing to do with it directly. • Why?

P Deoxy-ribose Transcription Deoxy-ribose Adenine P P P P P P P P Ribose Deoxy-ribose Deoxy-ribose Ribose Ribose Deoxy-ribose Thymine Guanine Uracil Adenine Guanine Adenine Cytosine P Sense Strand   Antisense Strand Deoxy-ribose Thymine

Transcription Animation • [Video]

Now for Translation • Translation is when the ribosome uses the mRNA strand to make a protein. • The ribosome links together amino acids based on the sequence found in the mRNA. • Quick Reminder: • Protein Monomer: Amino Acid • Protein Polymer: Polypeptide (a string of amino acids) • Quick Summary: • The two halves of the ribosome assemble around mRNA. • The ribosome “reads” the mRNA and calls over the appropriate amino acids.

Why do we need translation? • Just as the word “translation” normally means converting between languages, it means almost the same thing for the cell. • It’s sort of like the nucleus speaks in DNA and the rest of the cell speaks in proteins. • RNA and the ribosomes play the role of the translator.

Get those Amino Acid tables out! • Every three mRNA bases the ribosome reads is called a codon. • For example: • AUG • UUU • UCG • Each codon corresponds to a particular amino acid. • With a few exceptions.

One last thing… • Protein translation always starts with the codon called AUG. To which amino acid does this correspond on your table? • By the way, methionine can also appear in the middle of the amino acid sequence. It just has to be at the front. • Protein translation always stops on one of three codons called “stop codons”: • UAA • UAG • UGA

Translation Example • Here’s my mRNA sequence: • CGGAUGCUGAAGUGAGGC • Now here it is with the codons separated: • CGG | AUG | CUG | AAG | UGA | GGC • Now here it is when the amino acids linked together: • Methionine-Leucine-Lysine • Notice how I did not start at the beginning (not a start codon) and stopped at the stop codon.

Let’s try it… • Try #4 on your Transcriptlate Lab. • Remember, regardless of how your strand starts, your first amino acid must be methionine. • No matter how your strand ends, stop when you reach a STOP codon.

Let’s try it… • Two Activities: • First is a review – Build a DNA Molecule • http://learn.genetics.utah.edu/content/begin/dna/builddna/ • Do this until you get a message about how fast your rate is. • Second is new information – Transcribe and Translate a Gene • http://learn.genetics.utah.edu/content/begin/dna/transcribe/ • Do this until you finish it, then put your computer(s) away.

Last details on translation… • The amino acids that the cell strings together are originally each attached to a third kind of RNA. • tRNA (for transfer RNA) • tRNA delivers amino acids to the ribosome. • The ribosome adds the amino acids to the growing polypeptide chain (with peptide bonds) and the tRNA leaves. • The ribosome is also made of RNA, but a different kind. • rRNA (for ribosomal RNA) • Picture next slide…

tRNA and Anticodons • tRNA has a funny shape in most diagrams, but the important thing to know is that at one end is an anticodon (three tRNA bases - opposite of the codon).

Translation StepsKnow these! • Ribosome arrives at mRNA. • mRNA is pulled through the ribosome. • Start codon (methionine) signals tRNA to start arriving. • One tRNA matches up to the codons on mRNA to deposit an amino acid. • Another tRNA comes in at the next codon and adds another amino acid to the chain. • Process continues until stop codon is reached. At that point the polypeptide is complete.

Translation Mechanism MET This process continues until a stop codon is reached, at which point the mRNA strand, tRNA units, and rRNA subunits all are released. MET ISO PRO tRNA G GG tRNA U A C tRNA U A C tRNA U A U tRNA U A U Start Codon (Methionine) Large Ribosomal Subunit (rRNA) E Site A Site P Site mRNA A A U U G G U U A A U U G G U U A G A A G G A A A A C C C C U U C C U A G U C C A A A A U U A A G G Small Ribosomal Subunit (rRNA)

Side Note: Polyribosomes • Polyribosomes, also known as polysomesor ergosomes, are “structures” made of one mRNA strand and multiple ribosomes. • So in reality, when translation happens, it’s not just one ribosome per mRNA strand. • That would be too slow. • Polyribosomes speed up translation! http://medical-dictionary.thefreedictionary.com/_/viewer.aspx?path=dorland&name=polyribosome.jpg

Replication, Transcription, Translation

The Big Idea • Don’t forget the big idea: What are Transcription and Translation? • Think of getting a prescription. • Transcription is when the doctor gives you the note and you take it to the pharmacy. • mRNA is made in the nucleus and moves to the ribosome. • Translation is when the pharmacist gives you the medicine. • mRNA is read by the ribosome and proteins are made.

And now it’s time for… • Codon Bingo! • Everyone needs a copy of the universal genetic code and a blank bingo card. • Write all twenty amino acids on the card. There are more than twenty spaces so some will have to be written twice (none can be written more than twice). • Don’t include stop. • I’ll give you a DNA, mRNA, or tRNA sequence – you transcribe/translate it to an amino acid. • Be sure you’re correct!

Transcription/Translation Key Terms • Codon • Anticodon • mRNA • rRNA • tRNA • Start codon • Stop codons • Transcription • Translation • What else?

Closure • Translate the following mRNA codons and submit your results in the turn-in box. • AUG (don’t forget the amino acid name) • CAA • AUC • UGU • CCC • UGA

Closure Notes • Where does translation happen? • The cytoplasm • What structure is responsible for performing translation? • The ribosome

Closure Protein • The longest protein known to us right now is called Titin in short. • It’s got between 27,000 and 33,000 individual amino acids on it. • Multiply this by three to get a rough estimate of how many mRNA nucleotides are involved. • What does it do? • Helps you contract muscles. • And now…the full chemical name, which…again…was shortened to “Titin.” • Note: Next slide in size 1.9 font. • http://www.sarahmcculloch.com/luminary-uprise/2009/longest-word/

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asparaginylglutaminylasparaginylthreonylphenylalanylglutamylserylmethionylserylglycylleucylvalyltryp tophylthreonylserylalanylprolylalanyltitinmethionylglutaminylarginyltyrosylglutamylserylleucylphenylala nylalanylisoleucylcysteinylprolylprolylaspartylalanylaspartylaspartylaspartylleucylleucylarginylglutamin ylisoleucylalanylseryltyrosylglycylarginylglycyltyrosylthreonyltyrosylleucylleucylserylarginylalanylglycyl valylthreonylglycylalanylglutamylasparaginylarginylalanylalanylleucylprolylleucylasparaginylhistidylleu cylvalylalanyllysylleucyllysylglutamyltyrosylasparaginylalanylalanylprolylprolylleucylglutaminylglycylph enylalanylglycylisoleucylserylalanylprolylaspartylglutaminylvalyllysylalanylalanylisoleucylaspartylalany lglycylalanylalanylglycylalanylisoleucylserylglycylserylalanylisoleucylvalyllysylisoleucylisoleucylglutam ylglutaminylhistidylasparaginylisoleucylglutamylprolylglutamyllysylmethionylleucylalanylalanylleucyllys 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rylalanylprolylalanyltitinmethionylglutaminylarginyltyrosylglutamylserylleucylphenylalanylalanylisoleuc ylcysteinylprolylprolylaspartylalanylaspartylaspartylaspartylleucylleucylarginylglutaminylisoleucylalany lseryltyrosylglycylarginylglycyltyrosylthreonyltyrosylleucylleucylserylarginylalanylglycylvalylthreonylgly cylalanylglutamylasparaginylarginylalanylalanylleucylprolylleucylasparaginylhistidylleucylvalylalanylly sylleucyllysylglutamyltyrosylasparaginylalanylalanylprolylprolylleucylglutaminylglycylphenylalanylglycy lisoleucylserylalanylprolylaspartylglutaminylvalyllysylalanylalanylisoleucylaspartylalanylglycylalanylala nylglycylalanylisoleucylserylglycylserylalanylisoleucylvalyllysylisoleucylisoleucylglutamylglutaminylhist idylasparaginylisoleucylglutamylprolylglutamyllysylmethionylleucylalanylalanylleucyllysylvalylphenylal anylvalylglutaminylprolylmethionyllysylalanylalanylthreonylarginylacetylseryltyrosylserylisoleucylthreo nylserylprolylserylglutaminylphenylalanylvalylphenylalanylleucylserylserylvalyltryptophylalanylaspartyl prolylisoleucylglutamylleucylleucylasparaginylvalylcysteinylthreonylserylserylleucylglycylasparaginylgl utaminylphenylalanylglutaminylthreonylglutaminylglutaminylalanylarginylthreonylthreonylglutaminylval ylglutaminylglutaminylphenylalanylserylglutaminylvalyltryptophyllysylprolylphenylalanylprolylglutaminy lserylthreonylvalylarginylphenylalanylprolylglycylaspartylvalyltyrosyllysylvalyltyrosylarginyltyrosylaspar aginylalanylvalylleucylaspartylprolylleucylisoleucylthreonylalanylleucylleucylglycylthreonylphenylalany laspartylthreonylarginylasparaginylarginylisoleucylisoleucylglutamylvalylglutamylasparaginylglutaminy lglutaminylserylprolylthreonylthreonylalanylglutamylthreonylleucylaspartylalanylthreonylarginylarginylv alylaspartylaspartylalanylthreonylvalylalanylisoleucylarginylserylalanylasparaginylisoleucylasparaginyl leucylvalylasparaginylglutamylleucylvalylarginylglycylthreonylglycylleucyltyrosylasparaginylglutaminyl asparaginylthreonylphenylalanylglutamylserylmethionylserylglycylleucylvalyltryptophylthreonylserylala nylprolylalanyltitinmethionylglutaminylarginyltyrosylglutamylserylleucylphenylalanylalanylisoleucylcyst einylprolylprolylaspartylalanylaspartylaspartylaspartylleucylleucylarginylglutaminylisoleucylalanylserylt yrosylglycylarginylglycyltyrosylthreonyltyrosylleucylleucylserylarginylalanylglycylvalylthreonylglycylala nylglutamylasparaginylarginylalanylalanylleucylprolylleucylasparaginylhistidylleucylvalylalanyllysylleu cyllysylglutamyltyrosylasparaginylalanylalanylprolylprolylleucylglutaminylglycylphenylalanylglycylisole ucylserylalanylprolylaspartylglutaminylvalyllysylalanylalanylisoleucylaspartylalanylglycylalanylalanylgl ycylalanylisoleucylserylglycylserylalanylisoleucylvalyllysylisoleucylisoleucylglutamylglutaminylhistidyla sparaginylisoleucylglutamylprolylglutamyllysylmethionylleucylalanylalanylleucyllysylvalylphenylalanylv alylglutaminylprolylmethionyllysylalanylalanylthreonylarginylacetylseryltyrosylserylisoleucylthreonylser ylprolylserylglutaminylphenylalanylvalylphenylalanylleucylserylserylvalyltryptophylalanylaspartylprolyli soleucylglutamylleucylleucylasparaginylvalylcysteinylthreonylserylserylleucylglycylasparaginylglutami nylphenylalanylglutaminylthreonylglutaminylglutaminylalanylarginylthreonylthreonylglutaminylvalylglut aminylglutaminylphenylalanylserylglutaminylvalyltryptophyllysylprolylphenylalanylprolylglutaminylseryl threonylvalylarginylphenylalanylprolylglycylaspartylvalyltyrosyllysylvalyltyrosylarginyltyrosylasparagin ylalanylvalylleucylaspartylprolylleucylisoleucylthreonylalanylleucylleucylglycylthreonylphenylalanylasp artylthreonylarginylasparaginylarginylisoleucylisoleucylglutamylvalylglutamylasparaginylglutaminylglut aminylserylprolylthreonylthreonylalanylglutamylthreonylleucylaspartylalanylthreonylarginylarginylvalyl aspartylaspartylalanylthreonylvalylalanylisoleucylarginylserylalanylasparaginylisoleucylasparaginylleu cylvalylasparaginylglutamylleucylvalylarginylglycylthreonylglycylleucyltyrosylasparaginylglutaminylasp araginylthreonylphenylalanylglutamylserylmethionylserylglycylleucylvalyltryptophylthreonylserylalanyl prolylalanyltitinmethionylglutaminylarginyltyrosylglutamylserylleucylphenylalanylalanylmethionylthreon ylthreonylglutaminylarginyltyrosylglutamylserylleucylphenylalanylalanylglutaminylleucyllysylglutamylar ginyllysylglutamylglycylalanylphenylalanylvalylprolylphenylalanylvalylthreonylleucylglycylaspartylprolyl glycylisoleucylglutamylglutaminylserylleucyllysylisoleucylaspartylthreonylleucylisoleucylglutamylalanyl glycylalanylaspartylalanylleucylglutamylleucylglycylisoleucylprolylphenylalanylserylaspartylprolylleucy lalanylaspartylglycylprolylthreonylisoleucylglutaminylasparaginylalanylthreonylleucylarginylalanylphen ylalanylalanylalanylglycylvalylthreonylprolylalanylglutaminylcysteinylphenylalanylglutamylmethionylleu cylalanylleucylisoleucylarginylglutaminyllysylhistidylprolylthreonylisoleucylprolylisoleucylglycylleucylle ucylmethionyltyrosylalanylasparaginylleucylvalylphenylalanylasparaginyllysylglycylisoleucylaspartylgl utamylphenylalanyltyrosylalanylglutaminylcysteinylglutamyllysylvalylglycylvalylaspartylserylvalylleucyl valylalanylaspartylvalylprolylvalylglutaminylglutamylserylalanylprolylphenylalanylarginylglutaminylalan ylalanylleucylarginylhistidylasparaginylvalylalanylprolylisoleucylphenylalanylisoleucylcysteinylprolylpr olylaspartylalanylaspartylaspartylaspartylleucylleucylarginylglutaminylisoleucylalanylseryltyrosylglycyl arginylglycyltyrosylthreonyltyrosylleucylleucylserylarginylalanylglycylvalylthreonylglycylalanylglutamyl asparaginylarginylalanylalanylleucylprolylleucylasparaginylhistidylleucylvalylalanyllysylleucyllysylgluta myltyrosylasparaginylalanylalanylprolylprolylleucylglutaminylglycylphenylalanylglycylisoleucylserylala nylprolylaspartylglutaminylvalyllysylalanylalanylisoleucylaspartylalanylglycylalanylalanylglycylalanylis oleucylserylglycylserylalanylisoleucylvalyllysylisoleucylisoleucylglutamylglutaminylhistidylasparaginyli soleucylglutamylprolylglutamyllysylmethionylleucylalanylalanylleucyllysylvalylphenylalanylvalylglutami nylprolylmethionyllysylalanylalanylthreonylarginylacetylseryltyrosylserylisoleucylthreonylserylprolylser ylglutaminylphenylalanylvalylphenylalanylleucylserylserylvalyltryptophylalanylaspartylprolylisoleucylgl utamylleucylleucylasparaginylvalylcysteinylthreonylserylserylleucylglycylasparaginylglutaminylphenyl alanylglutaminylthreonylglutaminylglutaminylalanylarginylthreonylthreonylglutaminylvalylglutaminylglu taminylphenylalanylserylglutaminylvalyltryptophyllysylprolylphenylalanylprolylglutaminylserylthreonylv alylarginylphenylalanylprolylglycylaspartylvalyltyrosyllysylvalyltyrosylarginyltyrosylasparaginylalanylva lylleucylaspartylprolylleucylisoleucylthreonylalanylleucylleucylglycylthreonylphenylalanylaspartylthreo nylarginylasparaginylarginylisoleucylisoleucylglutamylvalylglutamylasparaginylglutaminylglutaminylse rylprolylthreonylthreonylalanylglutamylthreonylleucylaspartylalanylthreonylarginylarginylvalylaspartyla spartylalanylthreonylvalylalanylisoleucylarginylserylalanylasparaginylisoleucylasparaginylleucylvalyla sparaginylglutamylleucylvalylarginylglycylthreonylglycylleucyltyrosylasparaginylglutaminylasparaginylt hreonylphenylalanylglutamylserylmethionylserylglycylleucylvalyltryptophylthreonylserylalanylprolylala nyltitinmethionylglutaminylarginyltyrosylglutamylserylleucylphenylalanylalanylisoleucylcysteinylprolylp rolylaspartylalanylaspartylaspartylaspartylleucylleucylarginylglutaminylisoleucylalanylseryltyrosylglycy larginylglycyltyrosylthreonyltyrosylleucylleucylserylarginylalanylglycylvalylthreonylglycylalanylglutamyl asparaginylarginylalanylalanylleucylprolylleucylasparaginylhistidylleucylvalylalanyllysylleucyllysylgluta myltyrosylasparaginylalanylalanylprolylprolylleucylglutaminylglycylphenylalanylglycylisoleucylserylala nylprolylaspartylglutaminylvalyllysylalanylalanylisoleucylaspartylalanylglycylalanylalanylglycylalanylis oleucylserylglycylserylalanylisoleucylvalyllysylisoleucylisoleucylglutamylglutaminylhistidylasparaginyli soleucylglutamylprolylglutamyllysylmethionylleucylalanylalanylleucyllysylvalylphenylalanylvalylglutami nylprolylmethionyllysylalanylalanylthreonylarginylacetylseryltyrosylserylisoleucylthreonylserylprolylser ylglutaminylphenylalanylvalylphenylalanylleucylserylserylvalyltryptophylalanylaspartylprolylisoleucylgl utamylleucylleucylasparaginylvalylcysteinylthreonylserylserylleucylglycylasparaginylglutaminylphenyl alanylglutaminylthreonylglutaminylglutaminylalanylarginylthreonylthreonylglutaminylvalylglutaminylglu taminylphenylalanylserylglutaminylvalyltryptophyllysylprolylphenylalanylprolylglutaminylserylthreonylv alylarginylphenylalanylprolylglycylaspartylvalyltyrosyllysylvalyltyrosylarginyltyrosylasparaginylalanylva lylleucylaspartylprolylleucylisoleucylthreonylalanylleucylleucylglycylthreonylphenylalanylaspartylthreo nylarginylasparaginylarginylisoleucylisoleucylglutamylvalylglutamylasparaginylglutaminylglutaminylse rylprolylthreonylthreonylalanylglutamylthreonylleucylaspartylalanylthreonylarginylarginylvalylaspartyla spartylalanylthreonylvalylalanylisoleucylarginylserylalanylasparaginylisoleucylasparaginylleucylvalyla sparaginylglutamylleucylvalylarginylglycylthreonylglycylleucyltyrosylasparaginylglutaminylasparaginylt hreonylphenylalanylglutamylserylmethionylserylglycylleucylvalyltryptophylthreonylserylalanylprolylala nyltitinmethionylglutaminylarginyltyrosylglutamylserylleucylphenylalanylalanylisoleucylcysteinylprolylp rolylaspartylalanylaspartylaspartylaspartylleucylleucylarginylglutaminylisoleucylalanylseryltyrosylglycy larginylglycyltyrosylthreonyltyrosylleucylleucylserylarginylalanylglycylvalylthreonylglycylalanylglutamyl asparaginylarginylalanylalanylleucylprolylleucylasparaginylhistidylleucylvalylalanyllysylleucyllysylgluta myltyrosylasparaginylalanylalanylprolylprolylleucylglutaminylglycylphenylalanylglycylisoleucylserylala nylprolylaspartylglutaminylvalyllysylalanylalanylisoleucylaspartylalanylglycylalanylalanylglycylalanylis oleucylserylglycylserylalanylisoleucylvalyllysylisoleucylisoleucylglutamylglutaminylhistidylasparaginyli soleucylglutamylprolylglutamyllysylmethionylleucylalanylalanylleucyllysylvalylphenylalanylvalylglutami nylprolylmethionyllysylalanylalanylthreonylarginylacetylseryltyrosylserylisoleucylthreonylserylprolylser ylglutaminylphenylalanylvalylphenylalanylleucylserylserylvalyltryptophylalanylaspartylprolylisoleucylgl utamylleucylleucylasparaginylvalylcysteinylthreonylserylserylleucylglycylasparaginylglutaminylphenyl alanylglutaminylthreonylglutaminylglutaminylalanylarginylthreonylthreonylglutaminylvalylglutaminylglu taminylphenylalanylserylglutaminylvalyltryptophyllysylprolylphenylalanylprolylglutaminylserylthreonylv alylarginylphenylalanylprolylglycylaspartylvalyltyrosyllysylvalyltyrosylarginyltyrosylasparaginylalanylva lylleucylaspartylprolylleucylisoleucylthreonylalanylleucylleucylglycylthreonylphenylalanylaspartylthreo nylarginylasparaginylarginylisoleucylisoleucylglutamylvalylglutamylasparaginylglutaminylglutaminylse rylprolylthreonylthreonylalanylglutamylthreonylleucylaspartylalanylthreonylarginylarginylvalylaspartyla spartylalanylthreonylvalylalanylisoleucylarginylserylalanylasparaginylisoleucylasparaginylleucylvalyla sparaginylglutamylleucylvalylarginylglycylthreonylglycylleucyltyrosylasparaginylglutaminylasparaginylt hreonylphenylalanylglutamylserylmethionylserylglycylleucylvalyltryptophylthreonylserylalanylprolylala nyltitinmethionylglutaminylarginyltyrosylglutamylserylleucylphenylalanylalanylisoleucylcysteinylprolylp rolylaspartylalanylaspartylaspartylaspartylleucylleucylarginylglutaminylisoleucylalanylseryltyrosylglycy larginylglycyltyrosylthreonyltyrosylleucylleucylserylarginylalanylglycylvalylthreonylglycylalanylglutamyl asparaginylarginylalanylalanylleucylprolylleucylasparaginylhistidylleucylvalylalanyllysylleucyllysylgluta myltyrosylasparaginylalanylalanylprolylprolylleucylglutaminylglycylphenylalanylglycylisoleucylserylala nylprolylaspartylglutaminylvalyllysylalanylalanylisoleucylaspartylalanylglycylalanylalanylglycylalanylis oleucylserylglycylserylalanylisoleucylvalyllysylisoleucylisoleucylglutamylglutaminylhistidylasparaginyli soleucylglutamylprolylglutamyllysylmethionylleucylalanylalanylleucyllysylvalylphenylalanylvalylglutami nylprolylmethionyllysylalanylalanylthreonylarginylacetylseryltyrosylserylisoleucylthreonylserylprolylser ylglutaminylphenylalanylvalylphenylalanylleucylserylserylvalyltryptophylalanylaspartylprolylisoleucylgl utamylleucylleucylasparaginylvalylcysteinylthreonylserylserylleucylglycylasparaginylglutaminylphenyl alanylglutaminylthreonylglutaminylglutaminylalanylarginylthreonylthreonylglutaminylvalylglutaminylglu taminylphenylalanylserylglutaminylvalyltryptophyllysylprolylphenylalanylprolylglutaminylserylthreonylv alylarginylphenylalanylprolylglycylaspartylvalyltyrosyllysylvalyltyrosylarginyltyrosylasparaginylalanylva lylleucylaspartylprolylleucylisoleucylthreonylalanylleucylleucylglycylthreonylphenylalanylaspartylthreo nylarginylasparaginylarginylisoleucylisoleucylglutamylvalylglutamylasparaginylglutaminylglutaminylse rylprolylthreonylthreonylalanylglutamylthreonylleucylaspartylalanylthreonylarginylarginylvalylaspartyla spartylalanylthreonylvalylalanylisoleucylarginylserylalanylasparaginylisoleucylasparaginylleucylvalyla sparaginylglutamylleucylvalylarginylglycylthreonylglycylleucyltyrosylasparaginylglutaminylasparaginylt hreonylphenylalanylglutamylserylmethionylserylglycylleucylvalyltryptophylthreonylserylalanylprolylala nyltitinmethionylglutaminylarginyltyrosylglutamylserylleucylphenylalanylalanylmethionylthreonylthreon ylglutaminylarginyltyrosylglutamylserylleucylphenylalanylalanylglutaminylleucyllysylglutamylarginyllys ylglutamylglycylalanylphenylalanylvalylprolylphenylalanylvalylthreonylleucylglycylaspartylprolylglycylis oleucylglutamylglutaminylserylleucyllysylisoleucylaspartylthreonylleucylisoleucylglutamylalanylglycylal anylaspartylalanylleucylglutamylleucylglycylisoleucylprolylphenylalanylserylaspartylprolylleucylalanyla spartylglycylprolylthreonylisoleucylglutaminylasparaginylalanylthreonylleucylarginylalanylphenylalanyl alanylalanylglycylvalylthreonylprolylalanylglutaminylcysteinylphenylalanylglutamylmethionylleucylalan ylleucylisoleucylarginylglutaminyllysylhistidylprolylthreonylisoleucylprolylisoleucylglycylleucylleucylmet hionyltyrosylalanylasparaginylleucylvalylphenylalanylasparaginyllysylglycylisoleucylaspartylglutamylp henylalanyltyrosylalanylglutaminylcysteinylglutamyllysylvalylglycylvalylaspartylserylvalylleucylvalylala nylaspartylvalylprolylvalylglutaminylglutamylserylalanylprolylphenylalanylarginylglutaminylalanylalanyl leucylarginylhistidylasparaginylvalylalanylprolylisoleucylphenylalanylisoleucylcysteinylprolylprolylaspa rtylalanylaspartylaspartylaspartylleucylleucylarginylglutaminylisoleucylalanylseryltyrosylglycylarginylgl ycyltyrosylthreonyltyrosylleucylleucylserylarginylalanylglycylvalylthreonylglycylalanylglutamylasparagi nylarginylalanylalanylleucylprolylleucylasparaginylhistidylleucylvalylalanyllysylleucyllysylglutamyltyros ylasparaginylalanylalanylprolylprolylleucylglutaminylglycylphenylalanylglycylisoleucylserylalanylprolyl aspartylglutaminylvalyllysylalanylalanylisoleucylaspartylalanylglycylalanylalanylglycylalanylisoleucylse rylglycylserylalanylisoleucylvalyllysylisoleucylisoleucylglutamylglutaminylhistidylasparaginylisoleucylgl utamylprolylglutamyllysylmethionylleucylalanylalanylleucyllysylvalylphenylalanylvalylglutaminylprolylm ethionyllysylalanylalanylthreonylarginylacetylseryltyrosylserylisoleucylthreonylserylprolylserylglutamin ylphenylalanylvalylphenylalanylleucylserylserylvalyltryptophylalanylaspartylprolylisoleucylglutamylleuc ylleucylasparaginylvalylcysteinylthreonylserylserylleucylglycylasparaginylglutaminylphenylalanylgluta minylthreonylglutaminylglutaminylalanylarginylthreonylthreonylglutaminylvalylglutaminylglutaminylphe nylalanylserylglutaminylvalyltryptophyllysylprolylphenylalanylprolylglutaminylserylthreonylvalylarginylp henylalanylprolylglycylaspartylvalyltyrosyllysylvalyltyrosylarginyltyrosylasparaginylalanylvalylleucylasp artylprolylleucylisoleucylthreonylalanylleucylleucylglycylthreonylphenylalanylaspartylthreonylarginylas paraginylarginylisoleucylisoleucylglutamylvalylglutamylasparaginylglutaminylglutaminylserylprolylthre onylthreonylalanylglutamylthreonylleucylaspartylalanylthreonylarginylarginylvalylaspartylaspartylalany lthreonylvalylalanylisoleucylarginylserylalanylasparaginylisoleucylasparaginylleucylvalylasparaginylgl utamylleucylvalylarginylglycylthreonylglycylleucyltyrosylasparaginylglutaminylasparaginylthreonylphe nylalanylglutamylserylmethionylserylglycylleucylvalyltryptophylthreonylserylalanylprolylalanyltitinmethi onylglutaminylarginyltyrosylglutamylserylleucylphenylalanylalanylisoleucylcysteinylprolylprolylaspartyl alanylaspartylaspartylaspartylleucylleucylarginylglutaminylisoleucylalanylseryltyrosylglycylarginylglycy ltyrosylthreonyltyrosylleucylleucylserylarginylalanylglycylvalylthreonylglycylalanylglutamylasparaginyl arginylalanylalanylleucylprolylleucylasparaginylhistidylleucylvalylalanyllysylleucyllysylglutamyltyrosyla sparaginylalanylalanylprolylprolylleucylglutaminylglycylphenylalanylglycylisoleucylserylalanylprolylasp artylglutaminylvalyllysylalanylalanylisoleucylaspartylalanylglycylalanylalanylglycylalanylisoleucylserylg lycylserylalanylisoleucylvalyllysylisoleucylisoleucylglutamylglutaminylhistidylasparaginylisoleucylgluta mylprolylglutamyllysylmethionylleucylalanylalanylleucyllysylvalylphenylalanylvalylglutaminylprolylmeth ionyllysylalanylalanylthreonylarginylacetylseryltyrosylserylisoleucylthreonylserylprolylserylglutaminylp henylalanylvalylphenylalanylleucylserylserylvalyltryptophylalanylaspartylprolylisoleucylglutamylleucyll eucylasparaginylvalylcysteinylthreonylserylserylleucylglycylasparaginylglutaminylphenylalanylglutami nylthreonylglutaminylglutaminylalanylarginylthreonylthreonylglutaminylvalylglutaminylglutaminylpheny lalanylserylglutaminylvalyltryptophyllysylprolylphenylalanylprolylglutaminylserylthreonylvalylarginylphe nylalanylprolylglycylaspartylvalyltyrosyllysylvalyltyrosylarginyltyrosylasparaginylalanylvalylleucylaspar tylprolylleucylisoleucylthreonylalanylleucylleucylglycylthreonylphenylalanylaspartylthreonylarginylaspa raginylarginylisoleucylisoleucylglutamylvalylglutamylasparaginylglutaminylglutaminylserylprolylthreon ylthreonylalanylglutamylthreonylleucylaspartylalanylthreonylarginylarginylvalylaspartylaspartylalanylth reonylvalylalanylisoleucylarginylserylalanylasparaginylisoleucylasparaginylleucylvalylasparaginylgluta mylleucylvalylarginylglycylthreonylglycylleucyltyrosylasparaginylglutaminylasparaginylthreonylphenyla lanylglutamylserylmethionylserylglycylleucylvalyltryptophylthreonylserylalanylprolylalanyltitinmethionyl glutaminylarginyltyrosylglutamylserylleucylphenylalanylalanylisoleucylcysteinylprolylprolylaspartylalan ylaspartylaspartylaspartylleucylleucylarginylglutaminylisoleucylalanylseryltyrosylglycylarginylglycyltyro sylthreonyltyrosylleucylleucylserylarginylalanylglycylvalylthreonylglycylalanylglutamylasparaginylargin ylalanylalanylleucylprolylleucylasparaginylhistidylleucylvalylalanyllysylleucyllysylglutamyltyrosylaspar aginylalanylalanylprolylprolylleucylglutaminylglycylphenylalanylglycylisoleucylserylalanylprolylaspartyl glutaminylvalyllysylalanylalanylisoleucylaspartylalanylglycylalanylalanylglycylalanylisoleucylserylglycy lserylalanylisoleucylvalyllysylisoleucylisoleucylglutamylglutaminylhistidylasparaginylisoleucylglutamyl prolylglutamyllysylmethionylleucylalanylalanylleucyllysylvalylphenylalanylvalylglutaminylprolylmethion yllysylalanylalanylthreonylarginylacetylseryltyrosylserylisoleucylthreonylserylprolylserylglutaminylphen ylalanylvalylphenylalanylleucylserylserylvalyltryptophylalanylaspartylprolylisoleucylglutamylleucylleuc ylasparaginylvalylcysteinylthreonylserylserylleucylglycylasparaginylglutaminylphenylalanylglutaminylt hreonylglutaminylglutaminylalanylarginylthreonylthreonylglutaminylvalylglutaminylglutaminylphenylala nylserylglutaminylvalyltryptophyllysylprolylphenylalanylprolylglutaminylserylthreonylvalylarginylphenyl alanylprolylglycylaspartylvalyltyrosyllysylvalyltyrosylarginyltyrosylasparaginylalanylvalylleucylaspartyl prolylleucylisoleucylthreonylalanylleucylleucylglycylthreonylphenylalanylaspartylthreonylarginylaspara ginylarginylisoleucylisoleucylglutamylvalylglutamylasparaginylglutaminylglutaminylserylprolylthreonylt hreonylalanylglutamylthreonylleucylaspartylalanylthreonylarginylarginylvalylaspartylaspartylalanylthre onylvalylalanylisoleucylarginylserylalanylasparaginylisoleucylasparaginylleucylvalylasparaginylglutam ylleucylvalylarginylglycylthreonylglycylleucyltyrosylasparaginylglutaminylasparaginylthreonylphenylala nylglutamylserylmethionylserylglycylleucylvalyltryptophylthreonylserylalanylprolylalanyltitinmethionylgl utaminylarginyltyrosylglutamylserylleucylphenylalanylalanylisoleucylcysteinylprolylprolylaspartylalanyl aspartylaspartylaspartylleucylleucylarginylglutaminylisoleucylalanylseryltyrosylglycylarginylglycyltyros ylthreonyltyrosylleucylleucylserylarginylalanylglycylvalylthreonylglycylalanylglutamylasparaginylarginy lalanylalanylleucylprolylleucylasparaginylhistidylleucylvalylalanyllysylleucyllysylglutamyltyrosylaspara ginylalanylalanylprolylprolylleucylglutaminylglycylphenylalanylglycylisoleucylserylalanylprolylaspartylg 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ylmethionylserylglycylleucylvalyltryptophylthreonylserylalanylprolylalanyltitinmethionylglutaminylarginy ltyrosylglutamylserylleucylphenylalanylalanylisoleucylcysteinylprolylprolylaspartylalanylaspartylaspart ylaspartylleucylleucylarginylglutaminylisoleucylalanylseryltyrosylglycylarginylglycyltyrosylthreonyltyros ylleucylleucylserylarginylalanylglycylvalylthreonylglycylalanylglutamylasparaginylarginylalanylalanylle ucylprolylleucylasparaginylhistidylleucylvalylalanyllysylleucyllysylglutamyltyrosylasparaginylalanylalan ylprolylprolylleucylglutaminylglycylphenylalanylglycylisoleucylserylalanylprolylaspartylglutaminylvalylly sylalanylalanylisoleucylaspartylalanylglycylalanylalanylglycylalanylisoleucylserylglycylserylalanylisole ucylvalyllysylisoleucylisoleucylglutamylglutaminylhistidylasparaginylisoleucylglutamylprolylglutamyllys ylmethionylleucylalanylalanylleucyllysylvalylphenylalanylvalylglutaminylprolylmethionyllysylalanylalan ylthreonylarginylacetylseryltyrosylserylisoleucylthreonylserylprolylserylglutaminylphenylalanylvalylphe nylalanylleucylserylserylvalyltryptophylalanylaspartylprolylisoleucylglutamylleucylleucylasparaginylval ylcysteinylthreonylserylserylleucylglycylasparaginylglutaminylphenylalanylglutaminylthreonylglutamin ylglutaminylalanylarginylthreonylthreonylglutaminylvalylglutaminylglutaminylphenylalanylserylglutamin ylvalyltryptophyllysylprolylphenylalanylprolylglutaminylserylthreonylvalylarginylphenylalanylprolylglycy laspartylvalyltyrosyllysylvalyltyrosylarginyltyrosylasparaginylalanylvalylleucylaspartylprolylleucylisoleu cylthreonylalanylleucylleucylglycylthreonylphenylalanylaspartylthreonylarginylasparaginylarginylisoleu cylisoleucylglutamylvalylglutamylasparaginylglutaminylglutaminylserylprolylthreonylthreonylalanylglut amylthreonylleucylaspartylalanylthreonylarginylarginylvalylaspartylaspartylalanylthreonylvalylalanyliso 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ylasparaginylhistidylleucylvalylalanyllysylleucyllysylglutamyltyrosylasparaginylalanylalanylprolylprolyll eucylglutaminylglycylphenylalanylglycylisoleucylserylalanylprolylaspartylglutaminylvalyllysylalanylalan ylisoleucylaspartylalanylglycylalanylalanylglycylalanylisoleucylserylglycylserylalanylisoleucylvalyllysyli soleucylisoleucylglutamylglutaminylhistidylasparaginylisoleucylglutamylprolylglutamyllysylmethionylle ucylalanylalanylleucyllysylvalylphenylalanylvalylglutaminylprolylmethionyllysylalanylalanylthreonylargi nylacetylseryltyrosylserylisoleucylthreonylserylprolylserylglutaminylphenylalanylvalylphenylalanylleuc ylserylserylvalyltryptophylalanylaspartylprolylisoleucylglutamylleucylleucylasparaginylvalylcysteinylthr eonylserylserylleucylglycylasparaginylglutaminylphenylalanylglutaminylthreonylglutaminylglutaminylal anylarginylthreonylthreonylglutaminylvalylglutaminylglutaminylphenylalanylserylglutaminylvalyltryptop 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anylaspartylthreonylarginylasparaginylarginylisoleucylisoleucylglutamylvalylglutamylasparaginylgluta minylglutaminylserylprolylthreonylthreonylalanylglutamylthreonylleucylaspartylalanylthreonylarginylar ginylvalylaspartylaspartylalanylthreonylvalylalanylisoleucylarginylserylalanylasparaginylisoleucylaspar aginylleucylvalylasparaginylglutamylleucylvalylarginylglycylthreonylglycylleucyltyrosylasparaginylgluta minylasparaginylthreonylphenylalanylglutamylserylmethionylserylglycylleucylvalyltryptophylthreonylse rylalanylprolylalanyltitinmethionylglutaminylarginyltyrosylglutamylserylleucylphenylalanylalanylisoleuc ylcysteinylprolylprolylaspartylalanylaspartylaspartylaspartylleucylleucylarginylglutaminylisoleucylalany lseryltyrosylglycylarginylglycyltyrosylthreonyltyrosylleucylleucylserylarginylalanylglycylvalylthreonylgly cylalanylglutamylasparaginylarginylalanylalanylleucylprolylleucylasparaginylhistidylleucylvalylalanylly 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prolylalanyltitinmethionylglutaminylarginyltyrosylglutamylserylleucylphenylalanylalanylmethionylthreon ylthreonylglutaminylarginyltyrosylglutamylserylleucylphenylalanylalanylglutaminylleucyllysylglutamylar ginyllysylglutamylglycylalanylphenylalanylvalylprolylphenylalanylvalylthreonylleucylglycylaspartylprolyl glycylisoleucylglutamylglutaminylserylleucyllysylisoleucylaspartylthreonylleucylisoleucylglutamylalanyl glycylalanylaspartylalanylleucylglutamylleucylglycylisoleucylprolylphenylalanylserylaspartylprolylleucy lalanylaspartylglycylprolylthreonylisoleucylglutaminylasparaginylalanylthreonylleucylarginylalanylphen ylalanylalanylalanylglycylvalylthreonylprolylalanylglutaminylcysteinylphenylalanylglutamylmethionylleu cylalanylleucylisoleucylarginylglutaminyllysylhistidylprolylthreonylisoleucylprolylisoleucylglycylleucylle ucylmethionyltyrosylalanylasparaginylleucylvalylphenylalanylasparaginyllysylglycylisoleucylaspartylgl utamylphenylalanyltyrosylalanylglutaminylcysteinylglutamyllysylvalylglycylvalylaspartylserylvalylleucyl valylalanylaspartylvalylprolylvalylglutaminylglutamylserylalanylprolylphenylalanylarginylglutaminylalan ylalanylleucylarginylhistidylasparaginylvalylalanylprolylisoleucylphenylalanylisoleucylcysteinylprolylpr olylaspartylalanylaspartylaspartylaspartylleucylleucylarginylglutaminylisoleucylalanylseryltyrosylglycyl arginylglycyltyrosylthreonyltyrosylleucylleucylserylarginylalanylglycylvalylthreonylglycylalanylglutamyl asparaginylarginylalanylalanylleucylprolylleucylasparaginylhistidylleucylvalylalanyllysylleucyllysylgluta myltyrosylasparaginylalanylalanylprolylprolylleucylglutaminylglycylphenylalanylglycylisoleucylserylala nylprolylaspartylglutaminylvalyllysylalanylalanylisoleucylaspartylalanylglycylalanylalanylglycylalanylis oleucylserylglycylserylalanylisoleucylvalyllysylisoleucylisoleucylglutamylglutaminylhistidylasparaginyli soleucylglutamylprolylglutamyllysylmethionylleucylalanylalanylleucyllysylvalylphenylalanylvalylglutami nylprolylmethionyllysylalanylalanylthreonylarginylacetylseryltyrosylserylisoleucylthreonylserylprolylser ylglutaminylphenylalanylvalylphenylalanylleucylserylserylvalyltryptophylalanylaspartylprolylisoleucylgl utamylleucylleucylasparaginylvalylcysteinylthreonylserylserylleucylglycylasparaginylglutaminylphenyl alanylglutaminylthreonylglutaminylglutaminylalanylarginylthreonylthreonylglutaminylvalylglutaminylglu taminylphenylalanylserylglutaminylvalyltryptophyllysylprolylphenylalanylprolylglutaminylserylthreonylv alylarginylphenylalanylprolylglycylaspartylvalyltyrosyllysylvalyltyrosylarginyltyrosylasparaginylalanylva lylleucylaspartylprolylleucylisoleucylthreonylalanylleucylleucylglycylthreonylphenylalanylaspartylthreo nylarginylasparaginylarginylisoleucylisoleucylglutamylvalylglutamylasparaginylglutaminylglutaminylse rylprolylthreonylthreonylalanylglutamylthreonylleucylaspartylalanylthreonylarginylarginylvalylaspartyla spartylalanylthreonylvalylalanylisoleucylarginylserylalanylasparaginylisoleucylasparaginylleucylvalyla sparaginylglutamylleucylvalylarginylglycylthreonylglycylleucyltyrosylasparaginylglutaminylasparaginylt hreonylphenylalanylglutamylserylmethionylserylglycylleucylvalyltryptophylthreonylserylalanylprolylala nyltitinmethionylglutaminylarginyltyrosylglutamylserylleucylphenylalanylalanylisoleucylcysteinylprolylp rolylaspartylalanylaspartylaspartylaspartylleucylleucylarginylglutaminylisoleucylalanylseryltyrosylglycy larginylglycyltyrosylthreonyltyrosylleucylleucylserylarginylalanylglycylvalylthreonylglycylalanylglutamyl asparaginylarginylalanylalanylleucylprolylleucylasparaginylhistidylleucylvalylalanyllysylleucyllysylgluta myltyrosylasparaginylalanylalanylprolylprolylleucylglutaminylglycylphenylalanylglycylisoleucylserylala nylprolylaspartylglutaminylvalyllysylalanylalanylisoleucylaspartylalanylglycylalanylalanylglycylalanylis oleucylserylglycylserylalanylisoleucylvalyllysylisoleucylisoleucylglutamylglutaminylhistidylasparaginyli soleucylglutamylprolylglutamyllysylmethionylleucylalanylalanylleucyllysylvalylphenylalanylvalylglutami nylprolylmethionyllysylalanylalanylthreonylarginylacetylseryltyrosylserylisoleucylthreonylserylprolylser ylglutaminylphenylalanylvalylphenylalanylleucylserylserylvalyltryptophylalanylaspartylprolylisoleucylgl utamylleucylleucylasparaginylvalylcysteinylthreonylserylserylleucylglycylasparaginylglutaminylphenyl alanylglutaminylthreonylglutaminylglutaminylalanylarginylthreonylthreonylglutaminylvalylglutaminylglu taminylphenylalanylserylglutaminylvalyltryptophyllysylprolylphenylalanylprolylglutaminylserylthreonylv alylarginylphenylalanylprolylglycylaspartylvalyltyrosyllysylvalyltyrosylarginyltyrosylasparaginylalanylva lylleucylaspartylprolylleucylisoleucylthreonylalanylleucylleucylglycylthreonylphenylalanylaspartylthreo nylarginylasparaginylarginylisoleucylisoleucylglutamylvalylglutamylasparaginylglutaminylglutaminylse rylprolylthreonylthreonylalanylglutamylthreonylleucylaspartylalanylthreonylarginylarginylvalylaspartyla spartylalanylthreonylvalylalanylisoleucylarginylserylalanylasparaginylisoleucylasparaginylleucylvalyla sparaginylglutamylleucylvalylarginylglycylthreonylglycylleucyltyrosylasparaginylglutaminylasparaginylt hreonylphenylalanylglutamylserylmethionylserylglycylleucylvalyltryptophylthreonylserylalanylprolylala nyltitinmethionylglutaminylarginyltyrosylglutamylserylleucylphenylalanylalanylisoleucylcysteinylprolylp rolylaspartylalanylaspartylaspartylaspartylleucylleucylarginylglutaminylisoleucylalanylseryltyrosylglycy larginylglycyltyrosylthreonyltyrosylleucylleucylserylarginylalanylglycylvalylthreonylglycylalanylglutamyl asparaginylarginylalanylalanylleucylprolylleucylasparaginylhistidylleucylvalylalanyllysylleucyllysylgluta myltyrosylasparaginylalanylalanylprolylprolylleucylglutaminylglycylphenylalanylglycylisoleucylserylala nylprolylaspartylglutaminylvalyllysylalanylalanylisoleucylaspartylalanylglycylalanylalanylglycylalanylis oleucylserylglycylserylalanylisoleucylvalyllysylisoleucylisoleucylglutamylglutaminylhistidylasparaginyli soleucylglutamylprolylglutamyllysylmethionylleucylalanylalanylleucyllysylvalylphenylalanylvalylglutami nylprolylmethionyllysylalanylalanylthreonylarginylacetylseryltyrosylserylisoleucylthreonylserylprolylser ylglutaminylphenylalanylvalylphenylalanylleucylserylserylvalyltryptophylalanylaspartylprolylisoleucylgl utamylleucylleucylasparaginylvalylcysteinylthreonylserylserylleucylglycylasparaginylglutaminylphenyl alanylglutaminylthreonylglutaminylglutaminylalanylarginylthreonylthreonylglutaminylvalylglutaminylglu taminylphenylalanylserylglutaminylvalyltryptophyllysylprolylphenylalanylprolylglutaminylserylthreonylv alylarginylphenylalanylprolylglycylaspartylvalyltyrosyllysylvalyltyrosylarginyltyrosylasparaginylalanylva lylleucylaspartylprolylleucylisoleucylthreonylalanylleucylleucylglycylthreonylphenylalanylaspartylthreo nylarginylasparaginylarginylisoleucylisoleucylglutamylvalylglutamylasparaginylglutaminylglutaminylse rylprolylthreonylthreonylalanylglutamylthreonylleucylaspartylalanylthreonylarginylarginylvalylaspartyla spartylalanylthreonylvalylalanylisoleucylarginylserylalanylasparaginylisoleucylasparaginylleucylvalyla sparaginylglutamylleucylvalylarginylglycylthreonylglycylleucyltyrosylasparaginylglutaminylasparaginylt hreonylphenylalanylglutamylserylmethionylserylglycylleucylvalyltryptophylthreonylserylalanylprolylala nyltitinmethionylglutaminylarginyltyrosylglutamylserylleucylphenylalanylalanylisoleucylcysteinylprolylp rolylaspartylalanylaspartylaspartylaspartylleucylleucylarginylglutaminylisoleucylalanylseryltyrosylglycy larginylglycyltyrosylthreonyltyrosylleucylleucylserylarginylalanylglycylvalylthreonylglycylalanylglutamyl asparaginylarginylalanylalanylleucylprolylleucylasparaginylhistidylleucylvalylalanyllysylleucyllysylgluta myltyrosylasparaginylalanylalanylprolylprolylleucylglutaminylglycylphenylalanylglycylisoleucylserylala nylprolylaspartylglutaminylvalyllysylalanylalanylisoleucylaspartylalanylglycylalanylalanylglycylalanylis oleucylserylglycylserylalanylisoleucylvalyllysylisoleucylisoleucylglutamylglutaminylhistidylasparaginyli soleucylglutamylprolylglutamyllysylmethionylleucylalanylalanylleucyllysylvalylphenylalanylvalylglutami nylprolylmethionyllysylalanylalanylthreonylarginylacetylseryltyrosylserylisoleucylthreonylserylprolylser ylglutaminylphenylalanylvalylphenylalanylleucylserylserylvalyltryptophylalanylaspartylprolylisoleucylgl utamylleucylleucylasparaginylvalylcysteinylthreonylserylserylleucylglycylasparaginylglutaminylphenyl alanylglutaminylthreonylglutaminylglutaminylalanylarginylthreonylthreonylglutaminylvalylglutaminylglu taminylphenylalanylserylglutaminylvalyltryptophyllysylprolylphenylalanylprolylglutaminylserylthreonylv alylarginylphenylalanylprolylglycylaspartylvalyltyrosyllysylvalyltyrosylarginyltyrosylasparaginylalanylva lylleucylaspartylprolylleucylisoleucylthreonylalanylleucylleucylglycylthreonylphenylalanylaspartylthreo nylarginylasparaginylarginylisoleucylisoleucylglutamylvalylglutamylasparaginylglutaminylglutaminylse rylprolylthreonylthreonylalanylglutamylthreonylleucylaspartylalanylthreonylarginylarginylvalylaspartyla spartylalanylthreonylvalylalanylisoleucylarginylserylalanylasparaginylisoleucylasparaginylleucylvalyla sparaginylglutamylleucylvalylarginylglycylthreonylglycylleucyltyrosylasparaginylglutaminylasparaginylt hreonylphenylalanylglutamylserylmethionylserylglycylleucylvalyltryptophylthreonylserylalanylprolylala nyltitinmethionylglutaminylarginyltyrosylglutamylserylleucylphenylalanylalanylmethionylthreonylthreon ylglutaminylarginyltyrosylglutamylserylleucylphenylalanylalanylglutaminylleucyllysylglutamylarginyllys ylglutamylglycylalanylphenylalanylvalylprolylphenylalanylvalylthreonylleucylglycylaspartylprolylglycylis oleucylglutamylglutaminylserylleucyllysylisoleucylaspartylthreonylleucylisoleucylglutamylalanylglycylal anylaspartylalanylleucylglutamylleucylglycylisoleucylprolylphenylalanylserylaspartylprolylleucylalanyla spartylglycylprolylthreonylisoleucylglutaminylasparaginylalanylthreonylleucylarginylalanylphenylalanyl alanylalanylglycylvalylthreonylprolylalanylglutaminylcysteinylphenylalanylglutamylmethionylleucylalan ylleucylisoleucylarginylglutaminyllysylhistidylprolylthreonylisoleucylprolylisoleucylglycylleucylleucylmet 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paraginylarginylisoleucylisoleucylglutamylvalylglutamylasparaginylglutaminylglutaminylserylprolylthre onylthreonylalanylglutamylthreonylleucylaspartylalanylthreonylarginylarginylvalylaspartylaspartylalany lthreonylvalylalanylisoleucylarginylserylalanylasparaginylisoleucylasparaginylleucylvalylasparaginylgl utamylleucylvalylarginylglycylthreonylglycylleucyltyrosylasparaginylglutaminylasparaginylthreonylphe nylalanylglutamylserylmethionylserylglycylleucylvalyltryptophylthreonylserylalanylprolylalanyltitinmethi onylglutaminylarginyltyrosylglutamylserylleucylphenylalanylalanylisoleucylcysteinylprolylprolylaspartyl alanylaspartylaspartylaspartylleucylleucylarginylglutaminylisoleucylalanylseryltyrosylglycylarginylglycy ltyrosylthreonyltyrosylleucylleucylserylarginylalanylglycylvalylthreonylglycylalanylglutamylasparaginyl arginylalanylalanylleucylprolylleucylasparaginylhistidylleucylvalylalanyllysylleucyllysylglutamyltyrosyla sparaginylalanylalanylprolylprolylleucylglutaminylglycylphenylalanylglycylisoleucylserylalanylprolylasp artylglutaminylvalyllysylalanylalanylisoleucylaspartylalanylglycylalanylalanylglycylalanylisoleucylserylg lycylserylalanylisoleucylvalyllysylisoleucylisoleucylglutamylglutaminylhistidylasparaginylisoleucylgluta mylprolylglutamyllysylmethionylleucylalanylalanylleucyllysylvalylphenylalanylvalylglutaminylprolylmeth ionyllysylalanylalanylthreonylarginylacetylseryltyrosylserylisoleucylthreonylserylprolylserylglutaminylp henylalanylvalylphenylalanylleucylserylserylvalyltryptophylalanylaspartylprolylisoleucylglutamylleucyll eucylasparaginylvalylcysteinylthreonylserylserylleucylglycylasparaginylglutaminylphenylalanylglutami nylthreonylglutaminylglutaminylalanylarginylthreonylthreonylglutaminylvalylglutaminylglutaminylpheny lalanylserylglutaminylvalyltryptophyllysylprolylphenylalanylprolylglutaminylserylthreonylvalylarginylphe 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hreonylglutaminylglutaminylalanylarginylthreonylthreonylglutaminylvalylglutaminylglutaminylphenylala nylserylglutaminylvalyltryptophyllysylprolylphenylalanylprolylglutaminylserylthreonylvalylarginylphenyl alanylprolylglycylaspartylvalyltyrosyllysylvalyltyrosylarginyltyrosylasparaginylalanylvalylleucylaspartyl prolylleucylisoleucylthreonylalanylleucylleucylglycylthreonylphenylalanylaspartylthreonylarginylaspara ginylarginylisoleucylisoleucylglutamylvalylglutamylasparaginylglutaminylglutaminylserylprolylthreonylt hreonylalanylglutamylthreonylleucylaspartylalanylthreonylarginylarginylvalylaspartylaspartylalanylthre onylvalylalanylisoleucylarginylserylalanylasparaginylisoleucylasparaginylleucylvalylasparaginylglutam ylleucylvalylarginylglycylthreonylglycylleucyltyrosylasparaginylglutaminylasparaginylthreonylphenylala nylglutamylserylmethionylserylglycylleucylvalyltryptophylthreonylserylalanylprolylalanyltitinmethionylgl utaminylarginyltyrosylglutamylserylleucylphenylalanylalanylisoleucylcysteinylprolylprolylaspartylalanyl aspartylaspartylaspartylleucylleucylarginylglutaminylisoleucylalanylseryltyrosylglycylarginylglycyltyros ylthreonyltyrosylleucylleucylserylarginylalanylglycylvalylthreonylglycylalanylglutamylasparaginylarginy lalanylalanylleucylprolylleucylasparaginylhistidylleucylvalylalanyllysylleucyllysylglutamyltyrosylaspara ginylalanylalanylprolylprolylleucylglutaminylglycylphenylalanylglycylisoleucylserylalanylprolylaspartylg lutaminylvalyllysylalanylalanylisoleucylaspartylalanylglycylalanylalanylglycylalanylisoleucylserylglycyls erylalanylisoleucylvalyllysylisoleucylisoleucylglutamylglutaminylhistidylasparaginylisoleucylglutamylpr olylglutamyllysylmethionylleucylalanylalanylleucyllysylvalylphenylalanylvalylglutaminylprolylmethionyll ysylalanylalanylthreonylarginylacetylseryltyrosylserylisoleucylthreonylserylprolylserylglutaminylphenyl alanylvalylphenylalanylleucylserylserylvalyltryptophylalanylaspartylprolylisoleucylglutamylleucylleucyl asparaginylvalylcysteinylthreonylserylserylleucylglycylasparaginylglutaminylphenylalanylglutaminylthr eonylglutaminylglutaminylalanylarginylthreonylthreonylglutaminylvalylglutaminylglutaminylphenylalan ylserylglutaminylvalyltryptophyllysylprolylphenylalanylprolylglutaminylserylthreonylvalylarginylphenylal anylprolylglycylaspartylvalyltyrosyllysylvalyltyrosylarginyltyrosylasparaginylalanylvalylleucylaspartylpr olylleucylisoleucylthreonylalanylleucylleucylglycylthreonylphenylalanylaspartylthreonylarginylasparagi nylarginylisoleucylisoleucylglutamylvalylglutamylasparaginylglutaminylglutaminylserylprolylthreonylthr eonylalanylglutamylthreonylleucylaspartylalanylthreonylarginylarginylvalylaspartylaspartylalanylthreon ylvalylalanylisoleucylarginylserylalanylasparaginylisoleucylasparaginylleucylvalylasparaginylglutamyll eucylvalylarginylglycylthreonylglycylleucyltyrosylasparaginylglutaminylasparaginylthreonylphenylalan ylglutamylserylmethionylserylglycylleucylvalyltryptophylthreonylserylalanylprolylalanyltitinmethionylglu taminylarginyltyrosylglutamylserylleucylphenylalanylalanylmethionylthreonylthreonylglutaminylarginylt yrosylglutamylserylleucylphenylalanylalanylglutaminylleucyllysylglutamylarginyllysylglutamylglycylala nylphenylalanylvalylprolylphenylalanylvalylthreonylleucylglycylaspartylprolylglycylisoleucylglutamylglu taminylserylleucyllysylisoleucylaspartylthreonylleucylisoleucylglutamylalanylglycylalanylaspartylalanyll eucylglutamylleucylglycylisoleucylprolylphenylalanylserylaspartylprolylleucylalanylaspartylglycylprolylt hreonylisoleucylglutaminylasparaginylalanylthreonylleucylarginylalanylphenylalanylalanylalanylglycylv alylthreonylprolylalanylglutaminylcysteinylphenylalanylglutamylmethionylleucylalanylleucylisoleucylar 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ucylprolylleucylasparaginylhistidylleucylvalylalanyllysylleucyllysylglutamyltyrosylasparaginylalanylalan ylprolylprolylleucylglutaminylglycylphenylalanylglycylisoleucylserylalanylprolylaspartylglutaminylvalylly sylalanylalanylisoleucylaspartylalanylglycylalanylalanylglycylalanylisoleucylserylglycylserylalanylisole ucylvalyllysylisoleucylisoleucylglutamylglutaminylhistidylasparaginylisoleucylglutamylprolylglutamyllys ylmethionylleucylalanylalanylleucyllysylvalylphenylalanylvalylglutaminylprolylmethionyllysylalanylalan ylthreonylarginylacetylseryltyrosylserylisoleucylthreonylserylprolylserylglutaminylphenylalanylvalylphe nylalanylleucylserylserylvalyltryptophylalanylaspartylprolylisoleucylglutamylleucylleucylasparaginylval ylcysteinylthreonylserylserylleucylglycylasparaginylglutaminylphenylalanylglutaminylthreonylglutamin ylglutaminylalanylarginylthreonylthreonylglutaminylvalylglutaminylglutaminylphenylalanylserylglutamin 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aspartylleucylleucylarginylglutaminylisoleucylalanylseryltyrosylglycylarginylglycyltyrosylthreonyltyrosyl leucylleucylserylarginylalanylglycylvalylthreonylglycylalanylglutamylasparaginylarginylalanylalanylleuc ylprolylleucylasparaginylhistidylleucylvalylalanyllysylleucyllysylglutamyltyrosylasparaginylalanylalanyl prolylprolylleucylglutaminylglycylphenylalanylglycylisoleucylserylalanylprolylaspartylglutaminylvalyllys ylalanylalanylisoleucylaspartylalanylglycylalanylalanylglycylalanylisoleucylserylglycylserylalanylisoleu cylvalyllysylisoleucylisoleucylglutamylglutaminylhistidylasparaginylisoleucylglutamylprolylglutamyllysyl methionylleucylalanylalanylleucyllysylvalylphenylalanylvalylglutaminylprolylmethionyllysylalanylalanylt hreonylarginylacetylseryltyrosylserylisoleucylthreonylserylprolylserylglutaminylphenylalanylvalylpheny lalanylleucylserylserylvalyltryptophylalanylaspartylprolylisoleucylglutamylleucylleucylasparaginylvalylc ysteinylthreonylserylserylleucylglycylasparaginylglutaminylphenylalanylglutaminylthreonylglutaminylgl utaminylalanylarginylthreonylthreonylglutaminylvalylglutaminylglutaminylphenylalanylserylglutaminylv alyltryptophyllysylprolylphenylalanylprolylglutaminylserylthreonylvalylarginylphenylalanylprolylglycylas partylvalyltyrosyllysylvalyltyrosylarginyltyrosylasparaginylalanylvalylleucylaspartylprolylleucylisoleucylt hreonylalanylleucylleucylglycylthreonylphenylalanylaspartylthreonylarginylasparaginylarginylisoleucyli soleucylglutamylvalylglutamylasparaginylglutaminylglutaminylserylprolylthreonylthreonylalanylglutam ylthreonylleucylaspartylalanylthreonylarginylarginylvalylaspartylaspartylalanylthreonylvalylalanylisoleu cylarginylserylalanylasparaginylisoleucylasparaginylleucylvalylasparaginylglutamylleucylvalylarginylgl ycylthreonylglycylleucyltyrosylasparaginylglutaminylasparaginylthreonylphenylalanylglutamylserylmet hionylserylglycylleucylvalyltryptophylthreonylserylalanylprolylalanyltitinmethionylglutaminylarginyltyros ylglutamylserylleucylphenylalanylalanylisoleucylcysteinylprolylprolylaspartylalanylaspartylaspartylasp artylleucylleucylarginylglutaminylisoleucylalanylseryltyrosylglycylarginylglycyltyrosylthreonyltyrosylleu cylleucylserylarginylalanylglycylvalylthreonylglycylalanylglutamylasparaginylarginylalanylalanylleucylp rolylleucylasparaginylhistidylleucylvalylalanyllysylleucyllysylglutamyltyrosylasparaginylalanylalanylprol ylprolylleucylglutaminylglycylphenylalanylglycylisoleucylserylalanylprolylaspartylglutaminylvalyllysylal anylalanylisoleucylaspartylalanylglycylalanylalanylglycylalanylisoleucylserylglycylserylalanylisoleucylv alyllysylisoleucylisoleucylglutamylglutaminylhistidylasparaginylisoleucylglutamylprolylglutamyllysylmet hionylleucylalanylalanylleucyllysylvalylphenylalanylvalylglutaminylprolylmethionyllysylalanylalanylthre onylarginylacetylseryltyrosylserylisoleucylthreonylserylprolylserylglutaminylphenylalanylvalylphenylala nylleucylserylserylvalyltryptophylalanylaspartylprolylisoleucylglutamylleucylleucylasparaginylvalylcyst einylthreonylserylserylleucylglycylasparaginylglutaminylphenylalanylglutaminylthreonylglutaminylgluta minylalanylarginylthreonylthreonylglutaminylvalylglutaminylglutaminylphenylalanylserylglutaminylvalyl tryptophyllysylprolylphenylalanylprolylglutaminylserylthreonylvalylarginylphenylalanylprolylglycylaspar tylvalyltyrosyllysylvalyltyrosylarginyltyrosylasparaginylalanylvalylleucylaspartylprolylleucylisoleucylthre onylalanylleucylleucylglycylthreonylphenylalanylaspartylthreonylarginylasparaginylarginylisoleucylisol eucylglutamylvalylglutamylasparaginylglutaminylglutaminylserylprolylthreonylthreonylalanylglutamylth reonylleucylaspartylalanylthreonylarginylarginylvalylaspartylaspartylalanylthreonylvalylalanylisoleucyl 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anylglutaminylcysteinylphenylalanylglutamylmethionylleucylalanylleucylisoleucylarginylglutaminyllysyl histidylprolylthreonylisoleucylprolylisoleucylglycylleucylleucylmethionyltyrosylalanylasparaginylleucylv alylphenylalanylasparaginyllysylglycylisoleucylaspartylglutamylphenylalanyltyrosylalanylglutaminylcys teinylglutamyllysylvalylglycylvalylaspartylserylvalylleucylvalylalanylaspartylvalylprolylvalylglutaminylgl utamylserylalanylprolylphenylalanylarginylglutaminylalanylalanylleucylarginylhistidylasparaginylvalylal anylprolylisoleucylphenylalanylisoleucylcysteinylprolylprolylaspartylalanylaspartylaspartylaspartylleuc ylleucylarginylglutaminylisoleucylalanylseryltyrosylglycylarginylglycyltyrosylthreonyltyrosylleucylleucyl serylarginylalanylglycylvalylthreonylglycylalanylglutamylasparaginylarginylalanylalanylleucylprolylleuc ylasparaginylhistidylleucylvalylalanyllysylleucyllysylglutamyltyrosylasparaginylalanylalanylprolylprolyll 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nylglycylleucyltyrosylasparaginylglutaminylasparaginylthreonylphenylalanylglutamylserylmethionylser ylglycylleucylvalyltryptophylthreonylserylalanylprolylalanyltitinmethionylglutaminylarginyltyrosylglutam ylserylleucylphenylalanylalanylisoleucylcysteinylprolylprolylaspartylalanylaspartylaspartylaspartylleuc ylleucylarginylglutaminylisoleucylalanylseryltyrosylglycylarginylglycyltyrosylthreonyltyrosylleucylleucyl serylarginylalanylglycylvalylthreonylglycylalanylglutamylasparaginylarginylalanylalanylleucylprolylleuc ylasparaginylhistidylleucylvalylalanyllysylleucyllysylglutamyltyrosylasparaginylalanylalanylprolylprolyll eucylglutaminylglycylphenylalanylglycylisoleucylserylalanylprolylaspartylglutaminylvalyllysylalanylalan ylisoleucylaspartylalanylglycylalanylalanylglycylalanylisoleucylserylglycylserylalanylisoleucylvalyllysyli soleucylisoleucylglutamylglutaminylhistidylasparaginylisoleucylglutamylprolylglutamyllysylmethionylle ucylalanylalanylleucyllysylvalylphenylalanylvalylglutaminylprolylmethionyllysylalanylalanylthreonylargi nylacetylseryltyrosylserylisoleucylthreonylserylprolylserylglutaminylphenylalanylvalylphenylalanylleuc ylserylserylvalyltryptophylalanylaspartylprolylisoleucylglutamylleucylleucylasparaginylvalylcysteinylthr eonylserylserylleucylglycylasparaginylglutaminylphenylalanylglutaminylthreonylglutaminylglutaminylal anylarginylthreonylthreonylglutaminylvalylglutaminylglutaminylphenylalanylserylglutaminylvalyltryptop hyllysylprolylphenylalanylprolylglutaminylserylthreonylvalylarginylphenylalanylprolylglycylaspartylvalyl tyrosyllysylvalyltyrosylarginyltyrosylasparaginylalanylvalylleucylaspartylprolylleucylisoleucylthreonylal anylleucylleucylglycylthreonylphenylalanylaspartylthreonylarginylasparaginylarginylisoleucylisoleucylg lutamylvalylglutamylasparaginylglutaminylglutaminylserylprolylthreonylthreonylalanylglutamylthreonyll eucylaspartylalanylthreonylarginylarginylvalylaspartylaspartylalanylthreonylvalylalanylisoleucylarginyl serylalanylasparaginylisoleucylasparaginylleucylvalylasparaginylglutamylleucylvalylarginylglycylthreo nylglycylleucyltyrosylasparaginylglutaminylasparaginylthreonylphenylalanylglutamylserylmethionylser ylglycylleucylvalyltryptophylthreonylserylalanylprolylalanyltitinmethionylglutaminylarginyltyrosylglutam ylserylleucylphenylalanylalanylmethionylthreonylthreonylglutaminylarginyltyrosylglutamylserylleucylph enylalanylalanylglutaminylleucyllysylglutamylarginyllysylglutamylglycylalanylphenylalanylvalylprolylph enylalanylvalylthreonylleucylglycylaspartylprolylglycylisoleucylglutamylglutaminylserylleucyllysylisoleu cylaspartylthreonylleucylisoleucylglutamylalanylglycylalanylaspartylalanylleucylglutamylleucylglycyliso leucylprolylphenylalanylserylaspartylprolylleucylalanylaspartylglycylprolylthreonylisoleucylglutaminyla sparaginylalanylthreonylleucylarginylalanylphenylalanylalanylalanylglycylvalylthreonylprolylalanylgluta minylcysteinylphenylalanylglutamylmethionylleucylalanylleucylisoleucylarginylglutaminyllysylhistidylpr olylthreonylisoleucylprolylisoleucylglycylleucylleucylmethionyltyrosylalanylasparaginylleucylvalylphen ylalanylasparaginyllysylglycylisoleucylaspartylglutamylphenylalanyltyrosylalanylglutaminylcysteinylglu tamyllysylvalylglycylvalylaspartylserylvalylleucylvalylalanylaspartylvalylprolylvalylglutaminylglutamylse rylalanylprolylphenylalanylarginylglutaminylalanylalanylleucylarginylhistidylasparaginylvalylalanylproly lisoleucylphenylalanylisoleucylcysteinylprolylprolylaspartylalanylaspartylaspartylaspartylleucylleucylar ginylglutaminylisoleucylalanylseryltyrosylglycylarginylglycyltyrosylthreonyltyrosylleucylleucylserylargin ylalanylglycylvalylthreonylglycylalanylglutamylasparaginylarginylalanylalanylleucylprolylleucylasparagi nylhistidylleucylvalylalanyllysylleucyllysylglutamyltyrosylasparaginylalanylalanylprolylprolylleucylgluta minylglycylphenylalanylglycylisoleucylserylalanylprolylaspartylglutaminylvalyllysylalanylalanylisoleucyl aspartylalanylglycylalanylalanylglycylalanylisoleucylserylglycylserylalanylisoleucylvalyllysylisoleucylis oleucylglutamylglutaminylhistidylasparaginylisoleucylglutamylprolylglutamyllysylmethionylleucylalanyl alanylleucyllysylvalylphenylalanylvalylglutaminylprolylmethionyllysylalanylalanylthreonylarginylacetyls eryltyrosylserylisoleucylthreonylserylprolylserylglutaminylphenylalanylvalylphenylalanylleucylserylsery lvalyltryptophylalanylaspartylprolylisoleucylglutamylleucylleucylasparaginylvalylcysteinylthreonylseryls erylleucylglycylasparaginylglutaminylphenylalanylglutaminylthreonylglutaminylglutaminylalanylarginylt hreonylthreonylglutaminylvalylglutaminylglutaminylphenylalanylserylglutaminylvalyltryptophyllysylprol ylphenylalanylprolylglutaminylserylthreonylvalylarginylphenylalanylprolylglycylaspartylvalyltyrosyllysyl valyltyrosylarginyltyrosylasparaginylalanylvalylleucylaspartylprolylleucylisoleucylthreonylalanylleucylle ucylglycylthreonylphenylalanylaspartylthreonylarginylasparaginylarginylisoleucylisoleucylglutamylvalyl glutamylasparaginylglutaminylglutaminylserylprolylthreonylthreonylalanylglutamylthreonylleucylaspart ylalanylthreonylarginylarginylvalylaspartylaspartylalanylthreonylvalylalanylisoleucylarginylserylalanyla sparaginylisoleucylasparaginylleucylvalylasparaginylglutamylleucylvalylarginylglycylthreonylglycylleuc yltyrosylasparaginylglutaminylasparaginylthreonylphenylalanylglutamylserylmethionylserylglycylleucyl valyltryptophylthreonylserylalanylprolylalanyltitinmethionylglutaminylarginyltyrosylglutamylserylleucylp henylalanylalanylisoleucylcysteinylprolylprolylaspartylalanylaspartylaspartylaspartylleucylleucylarginyl glutaminylisoleucylalanylseryltyrosylglycylarginylglycyltyrosylthreonyltyrosylleucylleucylserylarginylala nylglycylvalylthreonylglycylalanylglutamylasparaginylarginylalanylalanylleucylprolylleucylasparaginylhi stidylleucylvalylalanyllysylleucyllysylglutamyltyrosylasparaginylalanylalanylprolylprolylleucylglutaminyl glycylphenylalanylglycylisoleucylserylalanylprolylaspartylglutaminylvalyllysylalanylalanylisoleucylaspa rtylalanylglycylalanylalanylglycylalanylisoleucylserylglycylserylalanylisoleucylvalyllysylisoleucylisoleuc ylglutamylglutaminylhistidylasparaginylisoleucylglutamylprolylglutamyllysylmethionylleucylalanylalanyl leucyllysylvalylphenylalanylvalylglutaminylprolylmethionyllysylalanylalanylthreonylarginylacetylseryltyr osylserylisoleucylthreonylserylprolylserylglutaminylphenylalanylvalylphenylalanylleucylserylserylvalylt ryptophylalanylaspartylprolylisoleucylglutamylleucylleucylasparaginylvalylcysteinylthreonylserylserylle ucylglycylasparaginylglutaminylphenylalanylglutaminylthreonylglutaminylglutaminylalanylarginylthreo nylthreonylglutaminylvalylglutaminylglutaminylphenylalanylserylglutaminylvalyltryptophyllysylprolylphe nylalanylprolylglutaminylserylthreonylvalylarginylphenylalanylprolylglycylaspartylvalyltyrosyllysylvalylt yrosylarginyltyrosylasparaginylalanylvalylleucylaspartylprolylleucylisoleucylthreonylalanylleucylleucylg lycylthreonylphenylalanylaspartylthreonylarginylasparaginylarginylisoleucylisoleucylglutamylvalylgluta mylasparaginylglutaminylglutaminylserylprolylthreonylthreonylalanylglutamylthreonylleucylaspartylala nylthreonylarginylarginylvalylaspartylaspartylalanylthreonylvalylalanylisoleucylarginylserylalanylaspar aginylisoleucylasparaginylleucylvalylasparaginylglutamylleucylvalylarginylglycylthreonylglycylleucyltyr osylasparaginylglutaminylasparaginylthreonylphenylalanylglutamylserylmethionylserylglycylleucylvaly ltryptophylthreonylserylalanylprolylalanyltitinmethionylglutaminylarginyltyrosylglutamylserylleucylphen ylalanylalanylisoleucylcysteinylprolylprolylaspartylalanylaspartylaspartylaspartylleucylleucylarginylglut aminylisoleucylalanylseryltyrosylglycylarginylglycyltyrosylthreonyltyrosylleucylleucylserylarginylalanyl glycylvalylthreonylglycylalanylglutamylasparaginylarginylalanylalanylleucylprolylleucylasparaginylhisti dylleucylvalylalanyllysylleucyllysylglutamyltyrosylasparaginylalanylalanylprolylprolylleucylglutaminylgl ycylphenylalanylglycylisoleucylserylalanylprolylaspartylglutaminylvalyllysylalanylalanylisoleucylaspart ylalanylglycylalanylalanylglycylalanylisoleucylserylglycylserylalanylisoleucylvalyllysylisoleucylisoleucyl glutamylglutaminylhistidylasparaginylisoleucylglutamylprolylglutamyllysylmethionylleucylalanylalanylle ucyllysylvalylphenylalanylvalylglutaminylprolylmethionyllysylalanylalanylthreonylarginylacetylseryltyro sylserylisoleucylthreonylserylprolylserylglutaminylphenylalanylvalylphenylalanylleucylserylserylvalyltry ptophylalanylaspartylprolylisoleucylglutamylleucylleucylasparaginylvalylcysteinylthreonylserylserylleu cylglycylasparaginylglutaminylphenylalanylglutaminylthreonylglutaminylglutaminylalanylarginylthreony lthreonylglutaminylvalylglutaminylglutaminylphenylalanylserylglutaminylvalyltryptophyllysylprolylpheny lalanylprolylglutaminylserylthreonylvalylarginylphenylalanylprolylglycylaspartylvalyltyrosyllysylvalyltyro sylarginyltyrosylasparaginylalanylvalylleucylaspartylprolylleucylisoleucylthreonylalanylleucylleucylglyc ylthreonylphenylalanylaspartylthreonylarginylasparaginylarginylisoleucylisoleucylglutamylvalylglutamy lasparaginylglutaminylglutaminylserylprolylthreonylthreonylalanylglutamylthreonylleucylaspartylalanylt hreonylarginylarginylvalylaspartylaspartylalanylthreonylvalylalanylisoleucylarginylserylalanylasparagin ylisoleucylasparaginylleucylvalylasparaginylglutamylleucylvalylarginylglycylthreonylglycylleucyltyrosyl asparaginylglutaminylasparaginylthreonylphenylalanylglutamylserylmethionylserylglycylleucylvalyltryp tophylthreonylserylalanylprolylalanyltitinmethionylglutaminylarginyltyrosylglutamylserylleucylphenylala nylalanylisoleucylcysteinylprolylprolylaspartylalanylaspartylaspartylaspartylleucylleucylarginylglutamin ylisoleucylalanylseryltyrosylglycylarginylglycyltyrosylthreonyltyrosylleucylleucylserylarginylalanylglycyl valylthreonylglycylalanylglutamylasparaginylarginylalanylalanylleucylprolylleucylasparaginylhistidylleu cylvalylalanyllysylleucyllysylglutamyltyrosylasparaginylalanylalanylprolylprolylleucylglutaminylglycylph enylalanylglycylisoleucylserylalanylprolylaspartylglutaminylvalyllysylalanylalanylisoleucylaspartylalany lglycylalanylalanylglycylalanylisoleucylserylglycylserylalanylisoleucylvalyllysylisoleucylisoleucylglutam ylglutaminylhistidylasparaginylisoleucylglutamylprolylglutamyllysylmethionylleucylalanylalanylleucyllys ylvalylphenylalanylvalylglutaminylprolylmethionyllysylalanylalanylthreonylarginylacetylseryltyrosylseryl isoleucylthreonylserylprolylserylglutaminylphenylalanylvalylphenylalanylleucylserylserylvalyltryptophyl alanylaspartylprolylisoleucylglutamylleucylleucylasparaginylvalylcysteinylthreonylserylserylleucylglycy lasparaginylglutaminylphenylalanylglutaminylthreonylglutaminylglutaminylalanylarginylthreonylthreon ylglutaminylvalylglutaminylglutaminylphenylalanylserylglutaminylvalyltryptophyllysylprolylphenylalanyl prolylglutaminylserylthreonylvalylarginylphenylalanylprolylglycylaspartylvalyltyrosyllysylvalyltyrosylargi nyltyrosylasparaginylalanylvalylleucylaspartylprolylleucylisoleucylthreonylalanylleucylleucylglycylthreo nylphenylalanylaspartylthreonylarginylasparaginylarginylisoleucylisoleucylglutamylvalylglutamylaspar aginylglutaminylglutaminylserylprolylthreonylthreonylalanylglutamylthreonylleucylaspartylalanylthreon ylarginylarginylvalylaspartylaspartylalanylthreonylvalylalanylisoleucylarginylserylalanylasparaginylisol eucylasparaginylleucylvalylasparaginylglutamylleucylvalylarginylglycylthreonylglycylleucyltyrosylaspar aginylglutaminylasparaginylthreonylphenylalanylglutamylserylmethionylserylglycylleucylvalyltryptophy lthreonylserylalanylprolylalanyltitinmethionylglutaminylarginyltyrosylglutamylserylleucylphenylalanylal anylmethionylthreonylthreonylglutaminylarginyltyrosylglutamylserylleucylphenylalanylalanylglutaminyll eucyllysylglutamylarginyllysylglutamylglycylalanylphenylalanylvalylprolylphenylalanylvalylthreonylleuc ylglycylaspartylprolylglycylisoleucylglutamylglutaminylserylleucyllysylisoleucylaspartylthreonylleucylis oleucylglutamylalanylglycylalanylaspartylalanylleucylglutamylleucylglycylisoleucylprolylphenylalanylse rylaspartylprolylleucylalanylaspartylglycylprolylthreonylisoleucylglutaminylasparaginylalanylthreonylle ucylarginylalanylphenylalanylalanylalanylglycylvalylthreonylprolylalanylglutaminylcysteinylphenylalany lglutamylmethionylleucylalanylleucylisoleucylarginylglutaminyllysylhistidylprolylthreonylisoleucylprolyli soleucylglycylleucylleucylmethionyltyrosylalanylasparaginylleucylvalylphenylalanylasparaginyllysylgly cylisoleucylaspartylglutamylphenylalanyltyrosylalanylglutaminylcysteinylglutamyllysylvalylglycylvalyla spartylserylvalylleucylvalylalanylaspartylvalylprolylvalylglutaminylglutamylserylalanylprolylphenylalany larginylglutaminylalanylalanylleucylarginylhistidylasparaginylvalylalanylprolylisoleucylphenylalanylisol eucylcysteinylprolylprolylaspartylalanylaspartylaspartylaspartylleucylleucylarginylglutaminylisoleucylal anylseryltyrosylglycylarginylglycyltyrosylthreonyltyrosylleucylleucylserylarginylalanylglycylvalylthreony lglycylalanylglutamylasparaginylarginylalanylalanylleucylprolylleucylasparaginylhistidylleucylvalylalan yllysylleucyllysylglutamyltyrosylasparaginylalanylalanylprolylprolylleucylglutaminylglycylphenylalanylgl ycylisoleucylserylalanylprolylaspartylglutaminylvalyllysylalanylalanylisoleucylaspartylalanylglycylalany lalanylglycylalanylisoleucylserylglycylserylalanylisoleucylvalyllysylisoleucylisoleucylglutamylglutaminyl histidylasparaginylisoleucylglutamylprolylglutamyllysylmethionylleucylalanylalanylleucyllysylvalylphen ylalanylvalylglutaminylprolylmethionyllysylalanylalanylthreonylarginylacetylseryltyrosylserylisoleucylth reonylserylprolylserylglutaminylphenylalanylvalylphenylalanylleucylserylserylvalyltryptophylalanylaspa rtylprolylisoleucylglutamylleucylleucylasparaginylvalylcysteinylthreonylserylserylleucylglycylasparagin ylglutaminylphenylalanylglutaminylthreonylglutaminylglutaminylalanylarginylthreonylthreonylglutaminy lvalylglutaminylglutaminylphenylalanylserylglutaminylvalyltryptophyllysylprolylphenylalanylprolylgluta minylserylthreonylvalylarginylphenylalanylprolylglycylaspartylvalyltyrosyllysylvalyltyrosylarginyltyrosyl asparaginylalanylvalylleucylaspartylprolylleucylisoleucylthreonylalanylleucylleucylglycylthreonylphenyl alanylaspartylthreonylarginylasparaginylarginylisoleucylisoleucylglutamylvalylglutamylasparaginylglut aminylglutaminylserylprolylthreonylthreonylalanylglutamylthreonylleucylaspartylalanylthreonylarginyla rginylvalylaspartylaspartylalanylthreonylvalylalanylisoleucylarginylserylalanylasparaginylisoleucylaspa raginylleucylvalylasparaginylglutamylleucylvalylarginylglycylthreonylglycylleucyltyrosylasparaginylglut aminylasparaginylthreonylphenylalanylglutamylserylmethionylserylglycylleucylvalyltryptophylthreonyls erylalanylprolylalanyltitinmethionylglutaminylarginyltyrosylglutamylserylleucylphenylalanylalanylisoleu cylcysteinylprolylprolylaspartylalanylaspartylaspartylaspartylleucylleucylarginylglutaminylisoleucylalan ylseryltyrosylglycylarginylglycyltyrosylthreonyltyrosylleucylleucylserylarginylalanylglycylvalylthreonylgl ycylalanylglutamylasparaginylarginylalanylalanylleucylprolylleucylasparaginylhistidylleucylvalylalanyll ysylleucyllysylglutamyltyrosylasparaginylalanylalanylprolylprolylleucylglutaminylglycylphenylalanylglyc ylisoleucylserylalanylprolylaspartylglutaminylvalyllysylalanylalanylisoleucylaspartylalanylglycylalanylal anylglycylalanylisoleucylserylglycylserylalanylisoleucylvalyllysylisoleucylisoleucylglutamylglutaminylhi stidylasparaginylisoleucylglutamylprolylglutamyllysylmethionylleucylalanylalanylleucyllysylvalylphenyl alanylvalylglutaminylprolylmethionyllysylalanylalanylthreonylarginylacetylseryltyrosylserylisoleucylthre onylserylprolylserylglutaminylphenylalanylvalylphenylalanylleucylserylserylvalyltryptophylalanylaspart ylprolylisoleucylglutamylleucylleucylasparaginylvalylcysteinylthreonylserylserylleucylglycylasparaginyl glutaminylphenylalanylglutaminylthreonylglutaminylglutaminylalanylarginylthreonylthreonylglutaminylv alylglutaminylglutaminylphenylalanylserylglutaminylvalyltryptophyllysylprolylphenylalanylprolylglutami nylserylthreonylvalylarginylphenylalanylprolylglycylaspartylvalyltyrosyllysylvalyltyrosylarginyltyrosylas paraginylalanylvalylleucylaspartylprolylleucylisoleucylthreonylalanylleucylleucylglycylthreonylphenylal anylaspartylthreonylarginylasparaginylarginylisoleucylisoleucylglutamylvalylglutamylasparaginylgluta minylglutaminylserylprolylthreonylthreonylalanylglutamylthreonylleucylaspartylalanylthreonylarginylar ginylvalylaspartylaspartylalanylthreonylvalylalanylisoleucylarginylserylalanylasparaginylisoleucylaspar aginylleucylvalylasparaginylglutamylleucylvalylarginylglycylthreonylglycylleucyltyrosylasparaginylgluta minylasparaginylthreonylphenylalanylglutamylserylmethionylserylglycylleucylvalyltryptophylthreonylse rylalanylprolylalanyltitinmethionylglutaminylarginyltyrosylglutamylserylleucylphenylalanylalanylisoleuc ylcysteinylprolylprolylaspartylalanylaspartylaspartylaspartylleucylleucylarginylglutaminylisoleucylalany lseryltyrosylglycylarginylglycyltyrosylthreonyltyrosylleucylleucylserylarginylalanylglycylvalylthreonylgly cylalanylglutamylasparaginylarginylalanylalanylleucylprolylleucylasparaginylhistidylleucylvalylalanylly sylleucyllysylglutamyltyrosylasparaginylalanylalanylprolylprolylleucylglutaminylglycylphenylalanylglycy lisoleucylserylalanylprolylaspartylglutaminylvalyllysylalanylalanylisoleucylaspartylalanylglycylalanylala nylglycylalanylisoleucylserylglycylserylalanylisoleucylvalyllysylisoleucylisoleucylglutamylglutaminylhist idylasparaginylisoleucylglutamylprolylglutamyllysylmethionylleucylalanylalanylleucyllysylvalylphenylal anylvalylglutaminylprolylmethionyllysylalanylalanylthreonylarginylacetylseryltyrosylserylisoleucylthreo nylserylprolylserylglutaminylphenylalanylvalylphenylalanylleucylserylserylvalyltryptophylalanylaspartyl prolylisoleucylglutamylleucylleucylasparaginylvalylcysteinylthreonylserylserylleucylglycylasparaginylgl utaminylphenylalanylglutaminylthreonylglutaminylglutaminylalanylarginylthreonylthreonylglutaminylval ylglutaminylglutaminylphenylalanylserylglutaminylvalyltryptophyllysylprolylphenylalanylprolylglutaminy lserylthreonylvalylarginylphenylalanylprolylglycylaspartylvalyltyrosyllysylvalyltyrosylarginyltyrosylaspar aginylalanylvalylleucylaspartylprolylleucylisoleucylthreonylalanylleucylleucylglycylthreonylphenylalany laspartylthreonylarginylasparaginylarginylisoleucylisoleucylglutamylvalylglutamylasparaginylglutaminy lglutaminylserylprolylthreonylthreonylalanylglutamylthreonylleucylaspartylalanylthreonylarginylarginylv alylaspartylaspartylalanylthreonylvalylalanylisoleucylarginylserylalanylasparaginylisoleucylasparaginyl leucylvalylasparaginylglutamylleucylvalylarginylglycylthreonylglycylleucyltyrosylasparaginylglutaminyl asparaginylthreonylphenylalanylglutamylserylmethionylserylglycylleucylvalyltryptophylthreonylserylala nylprolylalanyltitinmethionylglutaminylarginyltyrosylglutamylserylleucylphenylalanylalanylisoleucylcyst einylprolylprolylaspartylalanylaspartylaspartylaspartylleucylleucylarginylglutaminylisoleucylalanylserylt yrosylglycylarginylglycyltyrosylthreonyltyrosylleucylleucylserylarginylalanylglycylvalylthreonylglycylala nylglutamylasparaginylarginylalanylalanylleucylprolylleucylasparaginylhistidylleucylvalylalanyllysylleu cyllysylglutamyltyrosylasparaginylalanylalanylprolylprolylleucylglutaminylglycylphenylalanylglycylisole ucylserylalanylprolylaspartylglutaminylvalyllysylalanylalanylisoleucylaspartylalanylglycylalanylalanylgl ycylalanylisoleucylserylglycylserylalanylisoleucylvalyllysylisoleucylisoleucylglutamylglutaminylhistidyla sparaginylisoleucylglutamylprolylglutamyllysylmethionylleucylalanylalanylleucyllysylvalylphenylalanylv alylglutaminylprolylmethionyllysylalanylalanylthreonylarginylacetylseryltyrosylserylisoleucylthreonylser ylprolylserylglutaminylphenylalanylvalylphenylalanylleucylserylserylvalyltryptophylalanylaspartylprolyli soleucylglutamylleucylleucylasparaginylvalylcysteinylthreonylserylserylleucylglycylasparaginylglutami nylphenylalanylglutaminylthreonylglutaminylglutaminylalanylarginylthreonylthreonylglutaminylvalylglut aminylglutaminylphenylalanylserylglutaminylvalyltryptophyllysylprolylphenylalanylprolylglutaminylseryl threonylvalylarginylphenylalanylprolylglycylaspartylvalyltyrosyllysylvalyltyrosylarginyltyrosylasparagin ylalanylvalylleucylaspartylprolylleucylisoleucylthreonylalanylleucylleucylglycylthreonylphenylalanylasp artylthreonylarginylasparaginylarginylisoleucylisoleucylglutamylvalylglutamylasparaginylglutaminylglut aminylserylprolylthreonylthreonylalanylglutamylthreonylleucylaspartylalanylthreonylarginylarginylvalyl aspartylaspartylalanylthreonylvalylalanylisoleucylarginylserylalanylasparaginylisoleucylasparaginylleu cylvalylasparaginylglutamylleucylvalylarginylglycylthreonylglycylleucyltyrosylasparaginylglutaminylasp araginylthreonylphenylalanylglutamylserylmethionylserylglycylleucylvalyltryptophylthreonylserylalanyl prolylalanyltitinmethionylglutaminylarginyltyrosylglutamylserylleucylphenylalanylalanylmethionylthreon ylthreonylglutaminylarginyltyrosylglutamylserylleucylphenylalanylalanylglutaminylleucyllysylglutamylar ginyllysylglutamylglycylalanylphenylalanylvalylprolylphenylalanylvalylthreonylleucylglycylaspartylprolyl glycylisoleucylglutamylglutaminylserylleucyllysylisoleucylaspartylthreonylleucylisoleucylglutamylalanyl glycylalanylaspartylalanylleucylglutamylleucylglycylisoleucylprolylphenylalanylserylaspartylprolylleucy lalanylaspartylglycylprolylthreonylisoleucylglutaminylasparaginylalanylthreonylleucylarginylalanylphen ylalanylalanylalanylglycylvalylthreonylprolylalanylglutaminylcysteinylphenylalanylglutamylmethionylleu cylalanylleucylisoleucylarginylglutaminyllysylhistidylprolylthreonylisoleucylprolylisoleucylglycylleucylle ucylmethionyltyrosylalanylasparaginylleucylvalylphenylalanylasparaginyllysylglycylisoleucylaspartylgl utamylphenylalanyltyrosylalanylglutaminylcysteinylglutamyllysylvalylglycylvalylaspartylserylvalylleucyl valylalanylaspartylvalylprolylvalylglutaminylglutamylserylalanylprolylphenylalanylarginylglutaminylalan ylalanylleucylarginylhistidylasparaginylvalylalanylprolylisoleucylphenylalanylisoleucylcysteinylprolylpr olylaspartylalanylaspartylaspartylaspartylleucylleucylarginylglutaminylisoleucylalanylseryltyrosylglycyl arginylglycyltyrosylthreonyltyrosylleucylleucylserylarginylalanylglycylvalylthreonylglycylalanylglutamyl asparaginylarginylalanylalanylleucylprolylleucylasparaginylhistidylleucylvalylalanyllysylleucyllysylgluta myltyrosylasparaginylalanylalanylprolylprolylleucylglutaminylglycylphenylalanylglycylisoleucylserylala nylprolylaspartylglutaminylvalyllysylalanylalanylisoleucylaspartylalanylglycylalanylalanylglycylalanylis oleucylserylglycylserylalanylisoleucylvalyllysylisoleucylisoleucylglutamylglutaminylhistidylasparaginyli soleucylglutamylprolylglutamyllysylmethionylleucylalanylalanylleucyllysylvalylphenylalanylvalylglutami nylprolylmethionyllysylalanylalanylthreonylarginylacetylseryltyrosylserylisoleucylthreonylserylprolylser ylglutaminylphenylalanylvalylphenylalanylleucylserylserylvalyltryptophylalanylaspartylprolylisoleucylgl utamylleucylleucylasparaginylvalylcysteinylthreonylserylserylleucylglycylasparaginylglutaminylphenyl alanylglutaminylthreonylglutaminylglutaminylalanylarginylthreonylthreonylglutaminylvalylglutaminylglu taminylphenylalanylserylglutaminylvalyltryptophyllysylprolylphenylalanylprolylglutaminylserylthreonylv alylarginylphenylalanylprolylglycylaspartylvalyltyrosyllysylvalyltyrosylarginyltyrosylasparaginylalanylva lylleucylaspartylprolylleucylisoleucylthreonylalanylleucylleucylglycylthreonylphenylalanylaspartylthreo nylarginylasparaginylarginylisoleucylisoleucylglutamylvalylglutamylasparaginylglutaminylglutaminylse rylprolylthreonylthreonylalanylglutamylthreonylleucylaspartylalanylthreonylarginylarginylvalylaspartyla spartylalanylthreonylvalylalanylisoleucylarginylserylalanylasparaginylisoleucylasparaginylleucylvalyla sparaginylglutamylleucylvalylarginylglycylthreonylglycylleucyltyrosylasparaginylglutaminylasparaginylt hreonylphenylalanylglutamylserylmethionylserylglycylleucylvalyltryptophylthreonylserylalanylprolylala nyltitinmethionylglutaminylarginyltyrosylglutamylserylleucylphenylalanylalanylisoleucylcysteinylprolylp rolylaspartylalanylaspartylaspartylaspartylleucylleucylarginylglutaminylisoleucylalanylseryltyrosylglycy larginylglycyltyrosylthreonyltyrosylleucylleucylserylarginylalanylglycylvalylthreonylglycylalanylglutamyl asparaginylarginylalanylalanylleucylprolylleucylasparaginylhistidylleucylvalylalanyllysylleucyllysylgluta myltyrosylasparaginylalanylalanylprolylprolylleucylglutaminylglycylphenylalanylglycylisoleucylserylala nylprolylaspartylglutaminylvalyllysylalanylalanylisoleucylaspartylalanylglycylalanylalanylglycylalanylis oleucylserylglycylserylalanylisoleucylvalyllysylisoleucylisoleucylglutamylglutaminylhistidylasparaginyli soleucylglutamylprolylglutamyllysylmethionylleucylalanylalanylleucyllysylvalylphenylalanylvalylglutami nylprolylmethionyllysylalanylalanylthreonylarginylacetylseryltyrosylserylisoleucylthreonylserylprolylser ylglutaminylphenylalanylvalylphenylalanylleucylserylserylvalyltryptophylalanylaspartylprolylisoleucylgl utamylleucylleucylasparaginylvalylcysteinylthreonylserylserylleucylglycylasparaginylglutaminylphenyl alanylglutaminylthreonylglutaminylglutaminylalanylarginylthreonylthreonylglutaminylvalylglutaminylglu taminylphenylalanylserylglutaminylvalyltryptophyllysylprolylphenylalanylprolylglutaminylserylthreonylv alylarginylphenylalanylprolylglycylaspartylvalyltyrosyllysylvalyltyrosylarginyltyrosylasparaginylalanylva lylleucylaspartylprolylleucylisoleucylthreonylalanylleucylleucylglycylthreonylphenylalanylaspartylthreo nylarginylasparaginylarginylisoleucylisoleucylglutamylvalylglutamylasparaginylglutaminylglutaminylse rylprolylthreonylthreonylalanylglutamylthreonylleucylaspartylalanylthreonylarginylarginylvalylaspartyla spartylalanylthreonylvalylalanylisoleucylarginylserylalanylasparaginylisoleucylasparaginylleucylvalyla sparaginylglutamylleucylvalylarginylglycylthreonylglycylleucyltyrosylasparaginylglutaminylasparaginylt hreonylphenylalanylglutamylserylmethionylserylglycylleucylvalyltryptophylthreonylserylalanylprolylala nyltitinmethionylglutaminylarginyltyrosylglutamylserylleucylphenylalanylalanylisoleucylcysteinylprolylp rolylaspartylalanylaspartylaspartylaspartylleucylleucylarginylglutaminylisoleucylalanylseryltyrosylglycy larginylglycyltyrosylthreonyltyrosylleucylleucylserylarginylalanylglycylvalylthreonylglycylalanylglutamyl asparaginylarginylalanylalanylleucylprolylleucylasparaginylhistidylleucylvalylalanyllysylleucyllysylgluta myltyrosylasparaginylalanylalanylprolylprolylleucylglutaminylglycylphenylalanylglycylisoleucylserylala nylprolylaspartylglutaminylvalyllysylalanylalanylisoleucylaspartylalanylglycylalanylalanylglycylalanylis oleucylserylglycylserylalanylisoleucylvalyllysylisoleucylisoleucylglutamylglutaminylhistidylasparaginyli soleucylglutamylprolylglutamyllysylmethionylleucylalanylalanylleucyllysylvalylphenylalanylvalylglutami nylprolylmethionyllysylalanylalanylthreonylarginylacetylseryltyrosylserylisoleucylthreonylserylprolylser ylglutaminylphenylalanylvalylphenylalanylleucylserylserylvalyltryptophylalanylaspartylprolylisoleucylgl utamylleucylleucylasparaginylvalylcysteinylthreonylserylserylleucylglycylasparaginylglutaminylphenyl alanylglutaminylthreonylglutaminylglutaminylalanylarginylthreonylthreonylglutaminylvalylglutaminylglu taminylphenylalanylserylglutaminylvalyltryptophyllysylprolylphenylalanylprolylglutaminylserylthreonylv alylarginylphenylalanylprolylglycylaspartylvalyltyrosyllysylvalyltyrosylarginyltyrosylasparaginylalanylva lylleucylaspartylprolylleucylisoleucylthreonylalanylleucylleucylglycylthreonylphenylalanylaspartylthreo nylarginylasparaginylarginylisoleucylisoleucylglutamylvalylglutamylasparaginylglutaminylglutaminylse rylprolylthreonylthreonylalanylglutamylthreonylleucylaspartylalanylthreonylarginylarginylvalylaspartyla spartylalanylthreonylvalylalanylisoleucylarginylserylalanylasparaginylisoleucylasparaginylleucylvalyla sparaginylglutamylleucylvalylarginylglycylthreonylglycylleucyltyrosylasparaginylglutaminylasparaginylt hreonylphenylalanylglutamylserylmethionylserylglycylleucylvalyltryptophylthreonylserylalanylprolylala nyltitinmethionylglutaminylarginyltyrosylglutamylserylleucylphenylalanylalanylisoleucylcysteinylprolylp rolylaspartylalanylaspartylaspartylaspartylleucylleucylarginylglutaminylisoleucylalanylseryltyrosylglycy larginylglycyltyrosylthreonyltyrosylleucylleucylserylarginylalanylglycylvalylthreonylglycylalanylglutamyl asparaginylarginylalanylalanylleucylprolylleucylasparaginylhistidylleucylvalylalanyllysylleucyllysylgluta myltyrosylasparaginylalanylalanylprolylprolylleucylglutaminylglycylphenylalanylglycylisoleucylserylala nylprolylaspartylglutaminylvalyllysylalanylalanylisoleucylaspartylalanylglycylalanylalanylglycylalanylis oleucylserylglycylserylalanylisoleucylvalyllysylisoleucylisoleucylglutamylglutaminylhistidylasparaginyli soleucylglutamylprolylglutamyllysylmethionylleucylalanylalanylleucyllysylvalylphenylalanylvalylglutami nylprolylmethionyllysylalanylalanylthreonylarginylacetylseryltyrosylserylisoleucylthreonylserylprolylser ylglutaminylphenylalanylvalylphenylalanylleucylserylserylvalyltryptophylalanylaspartylprolylisoleucylgl utamylleucylleucylasparaginylvalylcysteinylthreonylserylserylleucylglycylasparaginylglutaminylphenyl alanylglutaminylthreonylglutaminylglutaminylalanylarginylthreonylthreonylglutaminylvalylglutaminylglu taminylphenylalanylserylglutaminylvalyltryptophyllysylprolylphenylalanylprolylglutaminylserylthreonylv alylarginylphenylalanylprolylglycylaspartylvalyltyrosyllysylvalyltyrosylarginyltyrosylasparaginylalanylva lylleucylaspartylprolylleucylisoleucylthreonylalanylleucylleucylglycylthreonylphenylalanylaspartylthreo nylarginylasparaginylarginylisoleucylisoleucylglutamylvalylglutamylasparaginylglutaminylglutaminylse rylprolylthreonylthreonylalanylglutamylthreonylleucylaspartylalanylthreonylarginylarginylvalylaspartyla spartylalanylthreonylvalylalanylisoleucylarginylserylalanylasparaginylisoleucylasparaginylleucylvalyla sparaginylglutamylleucylvalylarginylglycylthreonylglycylleucyltyrosylasparaginylglutaminylasparaginylt hreonylphenylalanylglutamylserylmethionylserylglycylleucylvalyltryptophylthreonylserylalanylprolylala nyltitinmethionylglutaminylarginyltyrosylglutamylserylleucylphenylalanylalanylmethionylthreonylthreon ylglutaminylarginyltyrosylglutamylserylleucylphenylalanylalanylglutaminylleucyllysylglutamylarginyllys ylglutamylglycylalanylphenylalanylvalylprolylphenylalanylvalylthreonylleucylglycylaspartylprolylglycylis oleucylglutamylglutaminylserylleucyllysylisoleucylaspartylthreonylleucylisoleucylglutamylalanylglycylal anylaspartylalanylleucylglutamylleucylglycylisoleucylprolylphenylalanylserylaspartylprolylleucylalanyla spartylglycylprolylthreonylisoleucylglutaminylasparaginylalanylthreonylleucylarginylalanylphenylalanyl alanylalanylglycylvalylthreonylprolylalanylglutaminylcysteinylphenylalanylglutamylmethionylleucylalan ylleucylisoleucylarginylglutaminyllysylhistidylprolylthreonylisoleucylprolylisoleucylglycylleucylleucylmet hionyltyrosylalanylasparaginylleucylvalylphenylalanylasparaginyllysylglycylisoleucylaspartylglutamylp henylalanyltyrosylalanylglutaminylcysteinylglutamyllysylvalylglycylvalylaspartylserylvalylleucylvalylala nylaspartylvalylprolylvalylglutaminylglutamylserylalanylprolylphenylalanylarginylglutaminylalanylalanyl leucylarginylhistidylasparaginylvalylalanylprolylisoleucylphenylalanylisoleucylcysteinylprolylprolylaspa rtylalanylaspartylaspartylaspartylleucylleucylarginylglutaminylisoleucylalanylseryltyrosylglycylarginylgl ycyltyrosylthreonyltyrosylleucylleucylserylarginylalanylglycylvalylthreonylglycylalanylglutamylasparagi nylarginylalanylalanylleucylprolylleucylasparaginylhistidylleucylvalylalanyllysylleucyllysylglutamyltyros ylasparaginylalanylalanylprolylprolylleucylglutaminylglycylphenylalanylglycylisoleucylserylalanylprolyl aspartylglutaminylvalyllysylalanylalanylisoleucylaspartylalanylglycylalanylalanylglycylalanylisoleucylse rylglycylserylalanylisoleucylvalyllysylisoleucylisoleucylglutamylglutaminylhistidylasparaginylisoleucylgl utamylprolylglutamyllysylmethionylleucylalanylalanylleucyllysylvalylphenylalanylvalylglutaminylprolylm ethionyllysylalanylalanylthreonylarginylacetylseryltyrosylserylisoleucylthreonylserylprolylserylglutamin ylphenylalanylvalylphenylalanylleucylserylserylvalyltryptophylalanylaspartylprolylisoleucylglutamylleuc ylleucylasparaginylvalylcysteinylthreonylserylserylleucylglycylasparaginylglutaminylphenylalanylgluta minylthreonylglutaminylglutaminylalanylarginylthreonylthreonylglutaminylvalylglutaminylglutaminylphe nylalanylserylglutaminylvalyltryptophyllysylprolylphenylalanylprolylglutaminylserylthreonylvalylarginylp henylalanylprolylglycylaspartylvalyltyrosyllysylvalyltyrosylarginyltyrosylasparaginylalanylvalylleucylasp artylprolylleucylisoleucylthreonylalanylleucylleucylglycylthreonylphenylalanylaspartylthreonylarginylas paraginylarginylisoleucylisoleucylglutamylvalylglutamylasparaginylglutaminylglutaminylserylprolylthre onylthreonylalanylglutamylthreonylleucylaspartylalanylthreonylarginylarginylvalylaspartylaspartylalany lthreonylvalylalanylisoleucylarginylserylalanylasparaginylisoleucylasparaginylleucylvalylasparaginylgl utamylleucylvalylarginylglycylthreonylglycylleucyltyrosylasparaginylglutaminylasparaginylthreonylphe nylalanylglutamylserylmethionylserylglycylleucylvalyltryptophylthreonylserylalanylprolylalanyltitinmethi onylglutaminylarginyltyrosylglutamylserylleucylphenylalanylalanylisoleucylcysteinylprolylprolylaspartyl alanylaspartylaspartylaspartylleucylleucylarginylglutaminylisoleucylalanylseryltyrosylglycylarginylglycy ltyrosylthreonyltyrosylleucylleucylserylarginylalanylglycylvalylthreonylglycylalanylglutamylasparaginyl arginylalanylalanylleucylprolylleucylasparaginylhistidylleucylvalylalanyllysylleucyllysylglutamyltyrosyla sparaginylalanylalanylprolylprolylleucylglutaminylglycylphenylalanylglycylisoleucylserylalanylprolylasp artylglutaminylvalyllysylalanylalanylisoleucylaspartylalanylglycylalanylalanylglycylalanylisoleucylserylg lycylserylalanylisoleucylvalyllysylisoleucylisoleucylglutamylglutaminylhistidylasparaginylisoleucylgluta mylprolylglutamyllysylmethionylleucylalanylalanylleucyllysylvalylphenylalanylvalylglutaminylprolylmeth ionyllysylalanylalanylthreonylarginylacetylseryltyrosylserylisoleucylthreonylserylprolylserylglutaminylp henylalanylvalylphenylalanylleucylserylserylvalyltryptophylalanylaspartylprolylisoleucylglutamylleucyll eucylasparaginylvalylcysteinylthreonylserylserylleucylglycylasparaginylglutaminylphenylalanylglutami nylthreonylglutaminylglutaminylalanylarginylthreonylthreonylglutaminylvalylglutaminylglutaminylpheny lalanylserylglutaminylvalyltryptophyllysylprolylphenylalanylprolylglutaminylserylthreonylvalylarginylphe nylalanylprolylglycylaspartylvalyltyrosyllysylvalyltyrosylarginyltyrosylasparaginylalanylvalylleucylaspar tylprolylleucylisoleucylthreonylalanylleucylleucylglycylthreonylphenylalanylaspartylthreonylarginylaspa raginylarginylisoleucylisoleucylglutamylvalylglutamylasparaginylglutaminylglutaminylserylprolylthreon ylthreonylalanylglutamylthreonylleucylaspartylalanylthreonylarginylarginylvalylaspartylaspartylalanylth reonylvalylalanylisoleucylarginylserylalanylasparaginylisoleucylasparaginylleucylvalylasparaginylgluta mylleucylvalylarginylglycylthreonylglycylleucyltyrosylasparaginylglutaminylasparaginylthreonylphenyla lanylglutamylserylmethionylserylglycylleucylvalyltryptophylthreonylserylalanylprolylalanyltitinmethionyl glutaminylarginyltyrosylglutamylserylleucylphenylalanylalanylisoleucylcysteinylprolylprolylaspartylalan ylaspartylaspartylaspartylleucylleucylarginylglutaminylisoleucylalanylseryltyrosylglycylarginylglycyltyro sylthreonyltyrosylleucylleucylserylarginylalanylglycylvalylthreonylglycylalanylglutamylasparaginylargin ylalanylalanylleucylprolylleucylasparaginylhistidylleucylvalylalanyllysylleucyllysylglutamyltyrosylaspar aginylalanylalanylprolylprolylleucylglutaminylglycylphenylalanylglycylisoleucylserylalanylprolylaspartyl glutaminylvalyllysylalanylalanylisoleucylaspartylalanylglycylalanylalanylglycylalanylisoleucylserylglycy lserylalanylisoleucylvalyllysylisoleucylisoleucylglutamylglutaminylhistidylasparaginylisoleucylglutamyl prolylglutamyllysylmethionylleucylalanylalanylleucyllysylvalylphenylalanylvalylglutaminylprolylmethion yllysylalanylalanylthreonylarginylacetylseryltyrosylserylisoleucylthreonylserylprolylserylglutaminylphen ylalanylvalylphenylalanylleucylserylserylvalyltryptophylalanylaspartylprolylisoleucylglutamylleucylleuc ylasparaginylvalylcysteinylthreonylserylserylleucylglycylasparaginylglutaminylphenylalanylglutaminylt hreonylglutaminylglutaminylalanylarginylthreonylthreonylglutaminylvalylglutaminylglutaminylphenylala nylserylglutaminylvalyltryptophyllysylprolylphenylalanylprolylglutaminylserylthreonylvalylarginylphenyl alanylprolylglycylaspartylvalyltyrosyllysylvalyltyrosylarginyltyrosylasparaginylalanylvalylleucylaspartyl prolylleucylisoleucylthreonylalanylleucylleucylglycylthreonylphenylalanylaspartylthreonylarginylaspara ginylarginylisoleucylisoleucylglutamylvalylglutamylasparaginylglutaminylglutaminylserylprolylthreonylt hreonylalanylglutamylthreonylleucylaspartylalanylthreonylarginylarginylvalylaspartylaspartylalanylthre onylvalylalanylisoleucylarginylserylalanylasparaginylisoleucylasparaginylleucylvalylasparaginylglutam ylleucylvalylarginylglycylthreonylglycylleucyltyrosylasparaginylglutaminylasparaginylthreonylphenylala nylglutamylserylmethionylserylglycylleucylvalyltryptophylthreonylserylalanylprolylalanyltitinmethionylgl utaminylarginyltyrosylglutamylserylleucylphenylalanylalanylisoleucylcysteinylprolylprolylaspartylalanyl aspartylaspartylaspartylleucylleucylarginylglutaminylisoleucylalanylseryltyrosylglycylarginylglycyltyros ylthreonyltyrosylleucylleucylserylarginylalanylglycylvalylthreonylglycylalanylglutamylasparaginylarginy lalanylalanylleucylprolylleucylasparaginylhistidylleucylvalylalanyllysylleucyllysylglutamyltyrosylaspara ginylalanylalanylprolylprolylleucylglutaminylglycylphenylalanylglycylisoleucylserylalanylprolylaspartylg lutaminylvalyllysylalanylalanylisoleucylaspartylalanylglycylalanylalanylglycylalanylisoleucylserylglycyls erylalanylisoleucylvalyllysylisoleucylisoleucylglutamylglutaminylhistidylasparaginylisoleucylglutamylpr olylglutamyllysylmethionylleucylalanylalanylleucyllysylvalylphenylalanylvalylglutaminylprolylmethionyll ysylalanylalanylthreonylarginylacetylseryltyrosylserylisoleucylthreonylserylprolylserylglutaminylphenyl alanylvalylphenylalanylleucylserylserylvalyltryptophylalanylaspartylprolylisoleucylglutamylleucylleucyl asparaginylvalylcysteinylthreonylserylserylleucylglycylasparaginylglutaminylphenylalanylglutaminylthr eonylglutaminylglutaminylalanylarginylthreonylthreonylglutaminylvalylglutaminylglutaminylphenylalan ylserylglutaminylvalyltryptophyllysylprolylphenylalanylprolylglutaminylserylthreonylvalylarginylphenylal anylprolylglycylaspartylvalyltyrosyllysylvalyltyrosylarginyltyrosylasparaginylalanylvalylleucylaspartylpr olylleucylisoleucylthreonylalanylleucylleucylglycylthreonylphenylalanylaspartylthreonylarginylasparagi nylarginylisoleucylisoleucylglutamylvalylglutamylasparaginylglutaminylglutaminylserylprolylthreonylthr eonylalanylglutamylthreonylleucylaspartylalanylthreonylarginylarginylvalylaspartylaspartylalanylthreon ylvalylalanylisoleucylarginylserylalanylasparaginylisoleucylasparaginylleucylvalylasparaginylglutamyll eucylvalylarginylglycylthreonylglycylleucyltyrosylasparaginylglutaminylasparaginylthreonylphenylalan ylglutamylserylmethionylserylglycylleucylvalyltryptophylthreonylserylalanylprolylalanyltitinmethionylglu taminylarginyltyrosylglutamylserylleucylphenylalanylalanylprolylprolylleucylglutaminylglycylphenylalan ylglycylisoleucylserylalanylprolylaspartylglutaminylvalyllysylalanylalanylisoleucylaspartylalanylglycylal anylalanylglycylalanylisoleucylserylglycylserylalanylisoleucylvalyllysylisoleucylisoleucylglutamylgluta minylhistidylasparaginylisoleucylglutamylprolylglutamyllysylmethionylleucylalanylalanylleucyllysylvalyl phenylalanylvalylglutaminylprolylmethionyllysylalanylalanylthreonylarginylacetylseryltyrosylserylisoleu cylthreonylserylprolylserylglutaminylphenylalanylvalylphenylalanylleucylserylserylvalyltryptophylalanyl aspartylprolylisoleucylglutamylleucylleucylasparaginylvalylcysteinylthreonylserylserylleucylglycylaspar aginylglutaminylphenylalanylglutaminylthreonylglutaminylglutaminylalanylarginylthreonylthreonylgluta minylvalylglutaminylglutaminylphenylalanylserylglutaminylvalyltryptophyllysylprolylphenylalanylprolylg lutaminylserylthreonylvalylarginylphenylalanylprolylglycylaspartylvalyltyrosyllysylvalyltyrosylarginyltyro sylasparaginylalanylvalylleucylaspartylprolylleucylisoleucylthreonylalanylleucylleucylglycylthreonylphe nylalanylaspartylthreonylarginylasparaginylarginylisoleucylisoleucylglutamylvalylglutamylasparaginylg lutaminylglutaminylserylprolylthreonylthreonylalanylglutamylthreonylleucylaspartylalanylthreonylargin ylarginylvalylaspartylaspartylalanylthreonylvalylalanylisoleucylarginylserylalanylasparaginylisoleucyla sparaginylleucylvalylasparaginylglutamylleucylvalylarginylglycylthreonylglycylleucyltyrosylasparaginyl glutaminylasparaginylthreonylphenylalanylglutamylserylmethionylserylglycylleucylvalyltryptophylthreo nylserylalanylprolylalanyltitinmethionylglutaminylarginyltyrosylglutamylserylleucylphenylalanylalanylpr olylprolylleucylglutaminylglycylphenylalanylglycylisoleucylserylalanylprolylaspartylglutaminylvalyllysyl alanylalanylisoleucylaspartylalanylglycylalanylalanylglycylalanylisoleucylserylglycylserylalanylisoleucy lvalyllysylisoleucylisoleucylglutamylglutaminylhistidylasparaginylisoleucylglutamylprolylglutamyllysylm ethionylleucylalanylalanylleucyllysylvalylphenylalanylvalylglutaminylprolylmethionyllysylalanylalanylthr eonylarginylacetylseryltyrosylserylisoleucylthreonylserylprolylserylglutaminylphenylalanylvalylphenylal anylleucylserylserylvalyltryptophylalanylaspartylprolylisoleucylglutamylleucylleucylasparaginylvalylcys teinylthreonylserylserylleucylglycylasparaginylglutaminylphenylalanylglutaminylthreonylglutaminylglut aminylalanylarginylthreonylthreonylglutaminylvalylglutaminylglutaminylphenylalanylserylglutaminylval yltryptophyllysylprolylphenylalanylprolylglutaminylserylthreonylvalylarginylphenylalanylprolylglycylasp artylvalyltyrosyllysylvalyltyrosylarginyltyrosylasparaginylalanylvalylleucylaspartylprolylleucylisoleucylth reonylalanylleucylleucylglycylthreonylphenylalanylaspartylthreonylarginylasparaginylarginylisoleucylis oleucylglutamylvalylglutamylasparaginylglutaminylglutaminylserylglutamylasparaginylglutaminylgluta minylserylglutamylasparaginylglutaminylglutaminylserxisoleucine

Today is Thursday, November 21 st , 2013

Today is Thursday, November 21 st , 2013

Presentation Transcript

Today is Thursday

Today is Thursday, November 7 th , 2013

Thursday, Feb. 21 st

Today is Monday, October 21 st , 2013

21 November 2013

November 21, 2013

November 21, 2013

Thursday, November 1 st

Today is Thursday, October 3 rd , 2013

Today is Friday (!), November (!) 1 st , 2013

Today is Thursday, September 19 th , 2013

Thursday November 21, 2013 Bellwork #4:

Today is Thursday, September 19 th , 2013

Today is Tuesday November 5, 2013

Thursday, November 21 st

November 21, 2013

Children’s Grief Awareness Day Thursday, November 21, 2013

Today is Thursday November 4 th ,2010

Wednesday 21 st November

November 21, 2013

Thursday , November 21, 2013

Today is Tuesday, October 21 st , 2014