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1. What�s New (and What�s Not) in Acne and Rosacea Adam O. Goldstein, MD Assistant Professor Department of Family Medicine University of North Carolina at Chapel Hill Email: aog@med.unc.edu

3. Objectives 1. Know differential diagnosis acne/rosacea 2. Increased knowledge treatment strategies 3. Increased familiarity new products 4. Learn 2 new patient education tips GOAL: Improved therapeutic outcomes

5. Acne Most common dermatologic disease Onset usually adolescence but anytime More frequent and severe in males 70% women premenstrual flares

6. Acne Quiz (T/F) 1. Certain foods make acne worse... 2. Dirty skin makes acne worse... 3. Acne worsens with sexual activity... 4. Acne improves within 24 hours of tx... 5. Sweating may make acne worse... 6. Humidity may exacerbate acne... 7. Acne may worsen during menstruation... 8. Stress may make acne worse...

7. Art of acne treatment: Negotiating long-term treatment Increasing compliance by using fewer medications Contracting with adolescents Thorough explanation of natural history of disease Patience with acne�s emotional toil Combining drugs @ different mechanisms

8. Art of acne treatment: �Quality of Life� scale 0 1 2 3 1. Feeling self-conscious 2. Decrease in socialization 3. Difficulties in relationships (partner, friends, family) 4. Feeling like an outcast 5. People making fun of you 6. Feeling rejected (romance, friends)

9. Common pitfalls in acne treatment Using more than two medications Insufficient patient education or unrealistic expectations Frustration all around

10. Acne: Etiology Combination hormonal (androgen), bacterial (Proprionibacterium acnes) and follicular (hyperkeratosis)causing debris and occlusion Bacteria multiply and inflammatory response Comedones: �Blackheads� and �Whiteheads� Blackheads = open comedones Whiteheads = closed comedones

12. Acne: Morphology Comedones Papules Pustules Nodules Cysts

17. Acne: Differential Diagnosis Rosacea: No comedones, erythema striking, central face Hidradenitis: Axilla & inguinal, nodules & cysts, scarring Keratosis Pilaris: Upper arms & trunks, follicular- based papules Perioral Derm.: Papulovesicles & erythema, perioral, topical steroid use Senile Comed.: Face & neck, comedones and cysts in damaged skin Topical steroids: Lesions same stage, no comedones

28. Acne: Treatment Treatment goal is to prevent new lesions/scarring Treatment will not improve outcomes for 4-6 weeks (Acne exacerbated by iodides, bromides, hydantoin, chlorinated hydrocarbons, occluding topical preparations, vigorous washing, and mechanical occlusion)

35. Mild acne: Apply one agent thinly to entire face If two agents selected, use at separate times Apply after washing with water or mild soap Choices: Benzoyl peroxide Topical antibiotics Tretinoin Birth Control Pills Azelaic acid Salicylic acid Use for 6-8 weeks before judging if effective

36. Mild acne Benzoyl peroxide ($) Antibacterial, drying and peeling actions Rx: 2.5-10% gel/cream/wash OTC: 2.5-10% gel/lotion/cream Usually start with 2.5-5%, thin layer QD-BID

37. Mild acne Benzoyl peroxide Water based preps are milder and less drying Alcohol/acetone preps useful in oily skin Washes and soaps are good for acne on the chest, back and shoulders (5-10%) Benzamycin gel- 23.3 grm- benzoyl peroxide and erythromycin- must be kept refrigerated

38. Mild acne: Benzoyl peroxide Side Effects Occasional hypersensitivity reactions (1-5%) Oxidating agent: will bleach clothes and hair

39. Mild acne Topical antibiotics (all Px) ($$) Erythromycin 2%- pledgettes, pads, gel (oily skin), solution, ointment (dry skin) Clindamycin 1%- solution, gel, lotion (e.g. Cleocin T) Meclocycline- cream; useful in patient with very dry skin (e.g. Meclan)

40. Mild acne: Topical antibiotics Sodium sulfacetamide 10%, Sulfur 5%, Sodium thiosulfate 10% Numerous keratolytic/astringent agents Useful if lotion preparation preferred and other topical antibiotics not working or tolerated Sulfacet R- tinted (can cover redness) Novacet- untinted Bacterial resistance may develop after 6-12 months of use

41. Mild acne: Topical Retinoids Especially good for comedonal or papular acne Modulates keratinization Use pea size amount to entire face Apply 3x week for 2 weeks, then nightly Increases photosensitivity Flare reaction frequent Web Sites: http://www.healthsquare.com/pdrfg/pd/ monos/retin-a.htm

42. Topical Retinoids Retin A (Renova) ($$$) Vehicles:0.025%, 0.05%, 0.1% cream; 0.01%, 0.025% gel Start with 0.025% strength Apply at bedtime 30 minutes after washing Avita Vehicles: 0.025% cream/gel Slow release polymer may be less irritating Retin A Micro Vehicle: 0.1% gel; Thick and yellow Slow release may be less irritating

43. Retinoid-Like Adapalene (Differin) ($$$) Vehicles: 0.1% gel, solution May apply right after washing at bedtime Tazarotene (Tazorac) Vehicles: 0.05, 0.1% gel Irritating initially May be useful with oily skin Short contact therapy

44. Retinoids-Comparisons Adapalene 0.1% gel vs. Tretinoin 0.025% gel, meta-analysis of 5 RCT�s (BMJ, 139S 1998) equivalent efficacy reducing total lesions Adapalene with significant difference in reduction of inflammatory and total lesions at week 1 Adapalene with greater local tolerability Adapalene 0.1% gel vs. Tretinoin 0.05% gel, Split-face clinical and bio-instrumental comparison (Dermatology. 198(2):218-22, 1999) Tretinoin with better comedolysis and clinical improvement than adapalene Erythema transiently more pronounced with tretinoin

45. Salicylic acid: 2% OTC ($) Keratolytic Many preparations Useful in combo with tretinoin or topical antibiotics

46. 20% Azelaic acid (Px) Mechanism unknown ($$) Useful for patients intolerant to tretinoin or benzoyl peroxide Avoid on broken skin Use qd-bid, usually in combination with other topicals

47. Acne and Birth Control Pills Lowers hormonal factors exacerbating acne Use pill with low androgenic potential Know side effects and contraindications Acne often improves during pregnancy

48. Moderate acne

49. Moderate acne Mild treatment + Add oral antibiotics Tetracycline- 500 mg bid or doxycycline 50-100 mg/day Erythromycin- 500 mg bid Minocycline- 50-100 mg/day Trimethoprim/Sulfamethoxazole 1 DS qd-bid Comedo removal

52. Severe acne Moderate regimen X 3 months Isotretinoin for severe nodulocystic acne Steroid injections TAC acetonide 10 mg/ml diluted to 3 mg/ml Inject 0.1 ml into fresh cyst Prednisone rarely Consultation

57. Isotretinoin (Accutane) 0.5-1 mg/kg/day 16-20 weeks 80% success rate Indications wider than previous thought Improvement continues after treatment stops Very teratogenic: (2 forms birth control for one month beforehand) Laboratory monitoring: (HCG before & monthly, CBC, LFT, TG, LDH, TG�s, Cholesterol, Q 2 weeks, then monthly) Use moisturizers, lip balms and artificial tears Monthly costs $200-400

58. Acne: Myths NO relation to junk foods NO relation to �hygiene� NO relation to masturbation or other sexual activity NO way to make acne go away overnight

59. Acne: Truths YES acne may worsen premenstrual YES sweating may worsen acne YES humid environments may worsen acne YES stress can exacerbate acne

60. Acne: Patient Education 6-8 week response Avoid scrubbing Keep regimen simple Compliance is key to FTIP; Have patient bring medications to office

61. Acne: Patient Education Use water-based makeup �Oil-free� moisturizers Web Sites: http://www.pslgroup.com/ACNE.htm Useful general information for clinicians http://www.derm-infonet.com/acnenet/toc.html Comprehensive site http://www.m2w3.com/acne/ Patient support group

62. Acne Rosacea �Rosy� dilatation of the central face: eyes, nose, chin, cheek, forehead Diverse spectrum of disease- (papules, pustules, nodules, cysts) Rhinophyma -hyperplasia of the nose in middle aged men

75. Acne Rosacea Look for periodic facial flushing after temperature increase, spicy food ingestion or alcohol Absence of comedones Disease is chronic: Treatment goal is control

76. Acne Rosacea: Differential Diagnosis Acne Vulgaris: comedones, younger patient, lack of flushing, less erythema Seb. dermatitis: no acneiform lesions Lupus: no papules and pustules Carcinoid: flushing is transient

77. Acne Rosacea: Treatment Topical Antibiotics, Benzoyl peroxide, Tretinoin Oral antibiotics Isotretinoin for severe, recalcitrant cases Referral for surgery, dermabrasion, laser Potent topical steroids often worsen disease

78. Acne Rosacea: Topical Therapy Preferred topical antibiotic: Metronidazole 0.1% cream (Noritate): qday 0.75% cream or gel: bid Alternatives: Sodium sulfacetamide 10%/sulfur 5% lotion Clindamycin 1% lotion, gel or solution Erythromycin 2% solution

79. Acne Rosacea: Topical Therapy Benzoyl peroxide at 2.5% & up to 10% if tolerated Tretinoin 0.025%, 0.05% 0.1% cream Start with lowest dose May be used in combination with other products

80. Acne Rosacea: Oral antibiotics Useful for nodular lesions Doxycycline 50-100 mg/day or tetracycline 500-1000 mg/day Minocycline 50-100 mg at bedtime Treat until improvement occurs, then taper for control

81. Acne Rosacea: Patient Education Control vs cure Avoid excessive sunlight, alcohol, temperature extremes and precipitating foods Flares may require higher �pulse� treatment Good web sites: National Rosacea Society http://www.rosacea.org/home.html Patient education brochure http://www.aad.org/pamphlets/rosacea.html

82. On the Horizon�. New retinoids Combination products: retinoids and topical antibiotics Glycolic acid, salicylic acid peels Hormonal treatments Antibiotic alternatives

83. Cases 14, Sports PE & whiteheads- incidental 16, with comedones and mild inflammation 16, before the prom 20, with sensitive skin, papular lesions and skin irritation 21, moderate acne on 0.1% Retina cream and 5% Benz. Peroxide, wanting referral to dermatologist 22, with extensive cystic acne for 5 years

84. Conclusion Be confident Use 1-2 agents if at all possible Define expectations Think about acne rosacea in adults