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CASE 2

CASE 2. 53 yo man HIV + 2006 CD4 340/16% (Nadir) VL 30,100 c/ml. CASE 2. BASELINE GENOTYPE OCT/06. CASE 2. April 2008 Abacavir /3TC/ Tenofovir /Ritonavir/ Lopinavir / Raltegravir /Maraviroc initiated as part of intensification study. CASE 2. CASE 2. March 2011

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CASE 2

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  1. CASE 2 • 53 yo man • HIV + 2006 • CD4 340/16% (Nadir) • VL 30,100 c/ml

  2. CASE 2 BASELINE GENOTYPE OCT/06

  3. CASE 2 April 2008 • Abacavir/3TC/Tenofovir/Ritonavir/ Lopinavir/Raltegravir/Maraviroc initiated as part of intensification study

  4. CASE 2

  5. CASE 2 • March 2011 • Regimen de-intensified to Truvada/Raltegravir as complex and VL=0 WHAT HAPPENED?

  6. CASE 2 GENOTYPE OCT/2011

  7. CASE 2 WHAT WOULD YOU DO ?

  8. CASE 2 Sept/2011 • Told to stop all therapy x 3 months in order to repopulate with wild-type

  9. CASE 2 Oct/2012-Jan/2012…No therapy • CD4 460/17%, 330/17% • VL 4851 c/ml, 3069 c/ml

  10. CASE 2 • Jan/2012 • Reinitiated ABC/3TC/RTV/DRV/ETR/RGV instead of ABC/3TC/TNF/RTV/LOP/RGV/MVC Would you de-intensify?

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