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BACKGROUND

Factors associated with medicine use among children from The 2004 Pelotas (Brazil) Birth Cohort Study. Edilson Almeida de Oliveira 1 ; Marlos Rodrigues Domingues 2 ; Iná S Santos 2 ; Aluísio J D Barros 2 ; Andréa Dâmaso Bertoldi 2

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BACKGROUND

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  1. Factors associated with medicine use among children from The 2004 Pelotas (Brazil) Birth Cohort Study Edilson Almeida de Oliveira1; Marlos Rodrigues Domingues2; Iná S Santos2; Aluísio J D Barros2; Andréa Dâmaso Bertoldi2 1Universidade do Vale do Rio dos Sinos. São Leopoldo, RS, Brazil2Universidade Federal de Pelotas. Pelotas, RS, Brazil andreadamaso.epi@gmail.com

  2. BACKGROUND • Medicine use among children is affected by many factors • Frequently, social aspects are even more important than medical reasons • Understanding medicine use patterns is one of the main goals of the pharmacoepidemiology • May help prevent irrational use

  3. OBJECTIVE • To investigate factors associated with general medicine use among children from the 2004 Pelotas Birth Cohort at the ages of three, 12 and 24 months

  4. METHODS • The 2004 Pelotas Birth Cohort (Brazil) is the third population-based birth cohort to be conducted in the city • Previous cohorts in 1982 and 1993 • All children born during 2004 in the urban area of Pelotas were enrolled • City's hospitals were visited on a daily basis by a trained staff of nutritionists in charge of interviews and anthropometric measurements

  5. METHODS • A prospective design was used to evaluate medicine use at the ages of three (N=3,985), 12 (N=3,907) and 24 months (N=3,868) • Outcome: use of any medicine in the previous 15 days • Independent variables included sociodemographic, perinatal, breastfeeding and maternal perception of child's health • Unadjusted and adjusted analyses were performed using Poisson regression models • Following a hierarchical model • With robust adjustment for the variance

  6. RESULTS • From the beginning of the study to the 24 months visit, losses and refusals reached 6.5% • The prevalence of medicine use ranged from 55-65% in the three periods • In all follow-up visits, medicine use was positively related to maternal education * Prevalence ratios and 95% Confidence Intervals ** Wald’s Linear Trend

  7. RESULTS • At 3 months, after controlling for confounders, highest use was observed among children…

  8. RESULTS • At 12 and 24 months, after controlling for confounders, highest use was observed among children…

  9. CONCLUSIONS • Different variables influenced medicine use among children in the first two years of life and these associations changed according to children's age • Most of the associated factors were related to the mother • Some were related to ill health among the children

  10. FUNDING SOURCES • Supported by • World Health Organization (WHO) • National Council for Scientific and Technologic Development (CNPq) • National Program for Excellence Centers (PRONEX) • Ministry of Health • Child’s Pastoral • Wellcome Trust

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