Caspase-8

Aug 24, 2014

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H226. H28. ZL5. ZL55. A. Mapa CDDP. - - + + - + - +. - - + + - + - +. - - + + - + - +. - - + + - + - +. pro (55/54kDa). Caspase-8. Bid. full length (22kDa).

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h28 zl5 zl55
lexa cddp
full length
caspase-8 bid
caspase-3
mapa cddp

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Caspase-8

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H226 H28 ZL5 ZL55 A Mapa CDDP - - + + - + - + - - + + - + - + - - + + - + - + - - + + - + - + pro (55/54kDa) Caspase-8 Bid full length (22kDa) pro (32kDa) Caspase-3 cleaved (17kDa) full length (37kDa) Mcl-1 full length (45kDa) ICAD cleaved (16.5kDa) Bax full length (23kDa) Survivin full length (16.5kDa) Actin H226 H28 ZL5 ZL55 B Lexa CDDP - - + + - + - + - - + + - + - + - - + + - + - + - - + + - + - + pro (55/54kDa) Caspase-8 Bid full length (22kDa) pro (32kDa) Caspase-3 cleaved (17kDa) Mcl-1 full length (37kDa) full length (45kDa) ICAD cleaved (16.5kDa) Bax full length (23kDa) Survivin full length (16.5kDa) Actin

The Caspase Family of Proteins

The Caspase Family of Proteins. C ysteine-dependent A spartate- S pecific P rote ase s. Outline. Overview 2 main classes of Caspases Regulation Activation Caspase Cascade Consequences of the Cascade References. Overview of Caspase. Cysteine proteases

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TRAIL Receptor and CD95 Signal to Mitochondria via FADD, Caspase-8

. FOOD FOR THOUGHT Look back at time before our birth. In this way Nature holds before our eyes the mirror of our future after death. Is this so grim, so gloomy? (Lucretius 1951) . BRIEF OVERVIEW. Types of cell death Necrosis: accidental type of death (many cells die) Apop

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Supplementary Figure 1. Caspase 8 expression and activation and Fas expression in NSCLC and normal lung cell lines.

a. b. #1. #2. #3. #5 Patient number. #4. BEAS-2B. Sq Ad Ad Ad Ad Squamous/Adeno. c. H460. Caspase 8 gene expression. N T N T N T N T N T N ormal/ T umour. DR5. DR4. β -Actin. #11. #12. #13. #15 Patient number. #14.

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8-8

8-8. The Pythagorean Theorem. Course 2. Warm Up. Problem of the Day. Lesson Presentation. 8-8. The Pythagorean Theorem. Course 2. Warm Up Estimate each square root to the nearest whole number. Use a calculator to check the reasonableness of your answers. 1. 2. 3. 4. √18. 5. √26.

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Caspase Cascade

Caspase Cascade. SIGMA-ALDRICH. Caspase Cascade

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MCF-7 Caspase-3 Cells

MDCK Cells. MCF-7 Caspase-3 Cells. TRK-MET. TRK-MET. TRK-MET. TRK-MET. Vector. Vector. Vector. zVAD. -. -. -. -. +. +. +. 170. TRK-MET V5. 126. 100. 73. 54. p40 MET. 46 kDa. WB MET. WB MET.

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Caspase-8

5-aza-dc - + - + - + - + - + -. CASP8. b- actin. 14. 12. 10. 5-aza-dc - - + + - -. M UM M UM M UM. 8. CASP8. Bisulfite sequence CASP8 promoter. MSP.

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Caspase Cascade

Caspase Cascade. TNFR. Fas. Calcium Channel. TNF. RAIDD. RAIDD. FADD. FADD. TRADD. TRADD. TRADD. Caspase1. Caspase9. Procaspase8. BAD. Caspase8. Caspase8. tBID. BID. CIAP. CIAP. F a s L. Caspase 3,6,7. SMAC/ DIABLO. TRAF2. RIP2. PAK1. JNK. RICK. NIK. DNA-PK. CytoC.

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Caspase Activation Intrinsic Pathway

Caspase Activation Intrinsic Pathway. SIGMA-ALDRICH.

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Caspase Activity in Apoptotic Cells

Caspase Activity in Apoptotic Cells. Cell Bio 220 Tenzin Dolkar Stephanie Kim Victoire Ndong Patricia Wong. Caspases. Are families of proteases which are involved in initiating apoptotic events Synthesized in the cell as precursors-procaspase Cleave proteins at aspartic acid residue sites

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Caspase-3 Activity

A. 8000. Caspase-3 Activity. 7000. 6000. 5000. Fluorescence Units / (min x mg). 4000. 3000. 2000. 1000. 0. Untreated. STS+ZVAD. 3-NP. STS. ZVAD. 3-NP+ZVAD. B. 120. Cell Death. 100. 80. Percent neurons with condensed Chromatin & shrunken soma. 60. 40. 20. 0. Untreated.

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Enhancement of stress-induced apoptosis in B-lineage cells by caspase-9 inhibitor

Enhancement of stress-induced apoptosis in B-lineage cells by caspase-9 inhibitor. Nisha Shah et al., BLOOD.2004;104:2873-2878. 生科四甲王彥閔 91390063. Introduction. B-lineage (BLIN) Acute lymphoblastic leukemia (ALL) cell line : BLIN-3, BLIN-4L Caspase-9 inhibitor (C9i)

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Multi-factor model for prediction of the caspase degradome Lawrence Wee

Multi-factor model for prediction of the caspase degradome Lawrence Wee. What are Caspases?. The Biochemistry of Caspases 1. Caspases are cysteine proteases. Recognize tetrapeptide sequence on substrates (P4-P3-P2-P1). P4 P3 P2 P1 P1’ P2’ - D– E – V – D --- T – Y.

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8-8

8-8. Completing the Square. Warm Up. Lesson Presentation. Lesson Quiz. Holt McDougal Algebra 1. Holt Algebra 1. Warm Up Simplify. 19. 1. 2. 3. 4. Warm Up Solve each quadratic equation by factoring. 5 . x 2 + 8 x + 16 = 0 6. x 2 – 22 x + 121 = 0. x = –4. x = 11. Objective.

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Caspase-6 (MBL)

JMR (C9-). F9 (C9+). Etoposide. Etoposide. anti-Fas. anti-Fas. Control. Control. 36. (short exposure). 50. Caspase-6 (MBL). 22. 16. 50. Caspase-2 (Alexis). 36. 4 5 6. 1 2 3. Lane. Supplementary Figure 2.

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Caspase-3

36. Caspase-3. Caspase-7. 36. 50. Actin. MCF-7 Jurkat. kDa. Supplementary Figure 4.

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Caspase Activity Assay

<b><a href="https://www.creative-bioarray.com/support/caspase-activity-assay.htm">Caspase Activity Assay</a></b> Caspases are a class of aspartate-specific cysteine proteases, which can be divided into three functional categories, initiator caspases (caspase-2, -8, -9, -10), effector caspases (caspase-3, -6, -7), and caspases involved in inflammatory cytokine process (caspase-1, -4, -5, 11, -12).

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caspase 14, apoptosis-related cysteine peptidase

Caspases are a family of cysteine proteases that are key mediators of programmed cell death or apoptosis.1 The precursor form of all caspases is composed of a prodomain and large and small catalytic subunits. The active forms of caspases are generated by several stimuli including ligand-receptor interactions, growth factor deprivation, and inhibitors of cellular functions. All known caspases require cleavage adjacent to aspartates to liberate one large and one small subunit, which associate into an a2b2 tetramer to form the active enzyme. Caspase-14 has a conserved active site pentapeptide, QACRG. However, no proteolytic or biological activities have been identified so far. Its high expression in embryonic tissues and limited expression in adult tissues suggests that it may have some role during ontogenesis.

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8-8

Solving Radical Equations and Inequalities. 8-8. Warm Up. Lesson Presentation. Lesson Quiz. Holt McDougal Algebra 2. Holt Algebra 2. Warm Up Simplify each expression. Assume all variables are positive. Write each expression in radical form. 2. 1. 4. 3. 5. 6. Objective.

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Multi-factor model for prediction of the caspase degradome Lawrence Wee

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Altered Caspase-8 Expression

Altered Caspase-8 Expression. Cancer Compound perturbations Gene perturbations Tumor development Cancer metastasis Cancer treatments. Nextbio. Caspase-8 Quickview. Correlation score is computed using rank-based enrichment algorithms. Caspase-8 Expression in Tissues and Cell Lines.

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