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BERAC April 2004

BERAC April 2004. Radiopharmaceutical Sub-committee Report. Charge from Director Office of Science.

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BERAC April 2004

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  1. BERACApril 2004 Radiopharmaceutical Sub-committee Report

  2. Charge from Director Office of Science • “( in view of major recent opportunities) to reassess how BER support might best stimulate directions in radiopharmaceutical research that are most likely to find translation into routine medical practice.” • Driven by concern for shortages • Key personnel, now and future • Optimized facilities and infrastructure

  3. DOE BER • Largely responsible for modern nuclear medicine • 99m Tc for cardiac, bone scanning, etc. • Many new probes and radiotracers for diagnosis and therapy • Patient care studies in the millions US and throughout the world • Era of Molecular Imaging: Key molecules, sub-cellular proteinomics, gene expression, whole cell function

  4. Imaging the process of stem cell repopulation of the bone marrow Gene expression labeling at 8 days

  5. 18FDG PET- CT Imaging Anatomy and FunctionPROSTATE CANCER MRSI MRI 18FDG PET-CT MRI T2 BOLD

  6. Why DOE • Essential infrastructure : physical sciences and expertise • Cyclotrons/ radiochemistry facilities • Radiochemistry, Organic Synthetic Chemistry Expertise, and biology relevant to modern imaging • Translates into unique facilities for molecular imaging tool development • Correlative Programs can provide depth of scientific expertise • Structural Biology • Nanotechnology • GTL

  7. Recommendations of RDP Sub-committee • Centers of Excellence • Training of Radiochemists and other chemists in allied disciplines, such as structural biology, medicinal chemistry • Collaboration and joint planning with NIH and other key governmental agencies • Regulatory review with FDA to faciitate probe development

  8. Progress • Partnership with NIH • Agreement on common goals • BERAC RDP Recc.s and NIH Road map • Collaboration • Role definition: DOE physical chemical and biologic science; NIH translatIon into man • NIBIB, exploring joint programs with respect to nuclear medicine centers of excellence for technology development and training

  9. Next Phase Detailed definition of “Centers of Excellence” and Training programs

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