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Chemical libraries in the SMSC: ChemBridge (ChemBridge Corp.) - 34,000 compounds

Chemical libraries in the SMSC: ChemBridge (ChemBridge Corp.) - 34,000 compounds - 34,000 selected from ~ 1,000,000 to create maximum chemical diversity - Historical: individually hand-made compounds LOPAC (Sigma-RBI) - 1280 compounds , (16 plates) - marketed drugs

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Chemical libraries in the SMSC: ChemBridge (ChemBridge Corp.) - 34,000 compounds

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  1. Chemical libraries in the SMSC: • ChemBridge (ChemBridge Corp.) - 34,000 compounds • - 34,000 selected from ~ 1,000,000 to create maximum chemical diversity • - Historical: individually hand-made compounds • LOPAC (Sigma-RBI) - 1280 compounds, (16 plates) • - marketed drugs • - development candidates • - “gold standards” with well-characterized activities • Spectrum (MicroSource) - 2000 compounds, (25 plates) <20% overlap with LOPAC • - Drug Components (50%) - Natural Products (30%) - Other Bioactive Components (20%) • NPL (TimTek) - 480 compounds, (6 plates) <25% overlap with Spectrum • - pure natural products from plants, bacteria, fungi, and animal sources (100%) • KIL80 – Kinase Inhibitors Library (Enzo Life Sciences) - 80 compounds (1 plate) • ChemBridge - screening for novel bioactive compounds • LOPAC, Spectrum, NPL - pilot screenings, testing and development of the readout system

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