Long-lasting depression-like behavior and epigenetic changes of BDNF gene expression induced by perinatal exposure to me

Feb 02, 2013

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Depression. 1 in 6 individual in US is affected from depression during their lifetimeApproximately 18.8 million American adults, or about 9.5 percent of the U.S. population age 18 and older in a given year, have a depressive disorderNearly twice as many women (12.0 percent) as men (6.6 percent) ar

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Long-lasting depression-like behavior and epigenetic changes of BDNF gene expression induced by perinatal exposure to me

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Presentation Transcript

Lasting Epigenetic Influence of Early-Life Adversity on the BDNF Gene

398 views • 24 slides

Perinatal Depression

Perinatal Depression. MCH Federal/State Partnership Meeting Alexandria, VA October 17, 2007 Diana Cheng, M.D. Medical Director, Women’s Health Maryland Department of Health and Mental Hygiene. Causes of Depression . hormones. Depression Across the Female Lifespan. Pregnancy/Postpartum.

465 views • 23 slides

Gene Expression

Gene Expression. Gene expression?. Biological processes, such as transcription, and in case of proteins, also translation, that yield a gene product. A gene is expressed when its biological product is present and active. Gene expression is regulated at multiple levels.

615 views • 32 slides

LONG-TERM, LASTING CHANGES

Theory of change: ‘Description of a sequence of events expected to lead to a particular desired outcome’, Rick Davies. For whom? Defined by whom ? Significant for whom?. LONG-TERM, LASTING CHANGES. Impact . SHORT-TERM CHANGES

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Perinatal Depression Update

Perinatal Depression Update . Laura J. Miller MD Director, Women’s Mental Health Division Brigham and Women’s Hospital Harvard Medical School. What we’ll cover. “ Perinatal ” depression is major (clinical) depression occurring during pregnancy and/or postpartum

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PERINATAL DEPRESSION

PERINATAL DEPRESSION. Improving Treatment Through Collaboration P. Lynn Ouellette M.D. Director, MAPP Postpartum Depression Project. OVERVIEW. Depression during pregnancy: rates, significance, Postpartum Depression: rates, risk factors, significance, risks of untreated PPD Screening for PPD

2.02k views • 61 slides

Ethanol-induced changes in G-proteins gene expression

Ethanol-induced changes in G-proteins gene expression. UEL Research & Knowledge Exchange Conference 2013 Stefano Casalotti Oghenetega Umukoro School of Health, Sport and Bioscience. More informative title:.

478 views • 41 slides

Gene Expression

Gene Expression. The human genome contains about 20,325 protein-encoding genes - However, this represents only a small part of the genome Much of the human genome controls protein synthesis - Including the time, speed, and location. Proteins have diverse functions in the body.

784 views • 59 slides

LONG-TERM, LASTING CHANGES

Theory of change: ‘ Description of a sequence of events expected to lead to a particular desired outcome ’ , Rick Davies. For whom? Defined by whom? Significant for whom?. LONG-TERM, LASTING CHANGES. Impact. SHORT-TERM CHANGES

146 views • 3 slides

Gene Structure and Gene Expression

Gene Structure and Gene Expression. Each chromosome contains one DNA molecule, which consists of roughly 80 million bases. How these extremely long molecules fit in a nucleus?. They are tightly associated with proteins to form nucleoprotein complex.

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Gene Expression

Gene Expression. Gene: contains the recipe for a protein. 1. is a specific region of DNA on a chromosome. 2. codes for a specific mRNA. mRNA: exits the nucleus and associates with ribosomes. 1. carries the code for a specific protein to the cytoplasm.

422 views • 26 slides

Gene Expression

Gene Expression. 1: Activation (overview), Transcription, Translation.  The Goodwin Equations. Review. An active gene is one that is being transcribed , and whose transcription product is being translated , and whose translation product affects cellular behavior/development.

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Epigenetic mechanisms of gene regulation

Epigenetic mechanisms of gene regulation. Chromatin structure Slows transcription Hypercondensation stops transcription Position effect variegation X inactivation Inactivation of one X chromosome in female mammals Genomic imprinting

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RNA-guided Epigenetic Control of Gene Expression

RNA-guided Epigenetic Control of Gene Expression.

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Gene Expression

Gene Expression. Review covering RNA Processing & Translation. Posttranscriptional ( RNA Processing). - Transcription has created a primary transcript (pre mRNA) that is not ready to be exported from the nucleus to the ribosome in the cytosol.

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Herbivore induced variation in gene expression

Herbivore induced variation in gene expression. TJ Sullivan Biology sullivant@hope.edu. Photograph. Education and experiences: B.A. in Biology, Carleton College Ph.D. in Ecology, Arizona St. University. Areas of expertise: Molecular ecology, species interactions.

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GENE EXPRESSION

GENE EXPRESSION. First genes must become AVAILABLE for expression. There are ROAD BLOCKS to becoming available. Exs . Does the cell have the needed DNA sequence?

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Gene expression

Gene expression. Transcription and Translation. 1. Important Features. a. DNA contains genetic template for proteins. b. DNA is found in the nucleus c. Protein synthesis occurs in the cytoplasm - ribosome.

487 views • 32 slides

Gene Expression

Gene Expression. Early evidence indicating most genes specify the structure of proteins Garrod’s work on inborn errors of metabolism in early 1900s Beadle and Tatum’s work with Neurospora mutants in the 1940s. An “inborn error of metabolism”. Mutations affecting biochemical pathways.

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