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Per J. Kraulis

Per J. Kraulis. Interactions between academia and the pharmaceutical industry Some experiences on understanding the other side. Academia and Industry. Pharmaceuticals, medicine, biotech In general: Good relations Last 10-15 years: Growing closer Many opportunities for collaboration.

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Per J. Kraulis

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  1. Per J. Kraulis Interactions between academia and the pharmaceutical industrySome experiences on understanding the other side

  2. Academia and Industry • Pharmaceuticals, medicine, biotech • In general: Good relations • Last 10-15 years: Growing closer • Many opportunities for collaboration

  3. My background • 1994-2000 Pharmacia & Upjohn • Drug discovery, target characterization • 2000-2003 Stockholm University • Stockholm Bioinformatics Center • 2003-2005 Biovitrum • Drug discovery, bioinformatics

  4. Discovery Research • Identification of potential drug target • Bioinformatics • Functional genomics • Validation in disease model • Identification of lead compounds • Compound optimization • Clinical aspects: limited experience

  5. Collaboration experience • Service for fee • Consultant • Academic project, company aspect • Joint project

  6. Advice and remarks • To the academic considering entering a collaboration with a company • Main focus: What can go wrong? • And how to avoid it • I am not sceptical about collaborations!

  7. Collaboration? Consider… • Company goals vs. academic goals • Time frame of project • Company decision making • Legal aspects: contracts

  8. Academia vs. Industry:Different ultimate goals! • Academia • Knowledge • Publication • Grants, support • New research • Industry • Information • Products • Sales • Market share • Share price • Profit

  9. Collaboration: What does it mean? • Many different variants • Service for fee • Purchase material/knowledge • Consultant • True joint project • ... • Watch out! Avoid misunderstandings

  10. Make expectations clear! • Unstated expectations: source of conflict • Dialog needed for understanding • State requests clearly from start • Not: "I need X. Now I need Y… And Z…" (JL) • Is the collaborator honest about goals?

  11. Dialog essential • What does the other party want? • Discuss foreseeable problems • Publication • Failure • Quitting prematurely • …

  12. What do you want? • Money • Support, payment, consultant • Salary for lab staff • Resources • Access to machines, methods • Materials, samples • Expertise, network • Results, data • Publications

  13. What does the company want? • Service for fee • Resources • Information • Access to methods • Expertise, network • Samples, materials • Development of idea or method • Goodwill, PR • Access to expertise, network

  14. Shorter collaboration • Time frame: weeks, months • Well-defined task and result • Simple agreement may work • Written (one page, email) • If recurrent: Draw up contract

  15. Longer collaboration 1 • Time frame: years • Dialog to understand expectations • Non-Disclosure Agreement • Disclose awkward data • Build trust: initial pre-project?

  16. Longer collaboration 2 • Contract essential, and difficult • Verbal agreement not good enough! • Define: • Goals, milestones • Management • Ownership • Data and results • Methods • Publication policy

  17. Time frames in industry • Depends on company situation • Profitable, stable, large: longer • Startup, no product, small: shorter • Usually < 3 years • Problem for Ph.D. student projects • May change drastically • Change of focus • Adverse events

  18. Company decision making • Who negotiates for the company? • Who signs the contract? • Formal company contact • Committee or person? • Responsibilities and powers? • Real company contact • Trust

  19. The reality of company decision making • Companies are not monoliths • There are conflicts in companies • Company policy may change abruptly • New CEO or CSO • Internal problems • Project failure • External pressure • Competition

  20. Plan for change • Minimze the risks of collaboration • Get payments in parts during lengthy project • Plan how to stop the project • The contract: your safety net • Forces the discussion • Talk things through first, then agree • For "bad weather conditions" • But: reputation may be more important

  21. Contracts are important • Professional legal advice • Within University? • Consultant • Standard contracts • Help from other academics • Friendly agreement: may work...

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