LABORATORIO DE MICOLOGIA IMTAvH PERSONAL Dra. Beatriz Bustamante, Jefe del Laboratorio MSc. Edgar Neyra, Asistente de In

1. LABORATORIO DE MICOLOGIA IMTAvH PERSONAL Dra. Beatriz Bustamante, Jefe del Laboratorio MSc. Edgar Neyra, Asistente de Investigación Tec.Lab. Carmen Castro Tec.Lab. Rosario Velando

2. DOCENCIA • Curso práctico de Micología en el Curso Gorgas Expert y Gorgas Regular • Prácticas de Micología en el Curso de Enfermedades Infecciosas y Tropicales: Alumnos de pre-grado 5to año de Medicina. • Practicas de Micología en el Curso Clinica, Tratamiento y • Prevención de Enfermedades infecciosas y Tropicales, • Curso de la Maestria en Control de Enfermedades Infecciosas y Tropicales. • Rotantes de Medicina: cada tercer miércoles del mes

3. TESIS • Para obtener el título de Licenciado en Tecnología Médica: • Echenique Carbajulca A. "Prevalencia de colonización por • Malassezia furfur en estudiantes de Tecnología Médica-UPCH • en el periodo Enero-Marzo, 2003“ • Para obtener el Título de Licenciado en Tecnología Médica: • Tello Barrientos S. " Contaminación ambiental por hongos en salas • de Operaciones y unidades de cuidados intensivos del Hospital • Nacionalcayetano Heredia, periodo Febrero-marzo, 2003"

4. TESIS • Para obtener el título de Licenciado en Tecnología Médica: • Huaringa M. “Colonización por Candida spp. Del tracto digestivo • de Neonatos hospitalizados en el Hospital Cayetano Heredia • durante los meses de Febrero a Marzo del 2003. • Para obtener el grado de Maestría en Microbiología: • Casquero J. "Evaluación de la resistencia in vitro a diferentes • antifúngicos en cepas de Cryptococcus neoformans aisladas de • pacientes VIH con recaídas de meningitis criptococósicas"

5. PROYECTOS DE INVESTIGACIÓN Estudios Clínicos: Project N: PO2095-79 IND N:51,662 Role: Bustamante B.,Principal Investigator Source. Schering-Plough Research Instutute Title of Project: " Open-Label, limited access protocol of Posaconazole in Invasive Fungal Infections". Objetives: to evaluate the safety of posaconazole for patients with invasive fungal infections which are refractory or resistant to standard antifungal therapies, or for which the are currently no effective therapies, or for patients with a prior history of serious, severe or life-threatening toxicities while receiving standard antifungal therapies. Dates of Project: 2003-Ongoing

6. Project N: CSFO 327L2302 Role: Bustamante B.,Co-Investigator Source: Novartis Pharmaceuticals Corporation Title of Project: "A multicenter, double blind, double-dummy, parallel group study to assess the efficacy, safety and tolerability of new oral formulation terbianfinein patients with onychomycosis of the toenails". The major goal of this project is: To compare new oral formulation Terbinafine having a smaller total dose to the current standard regimen of terbinafine for efficacy and safety and to placebo for the treatment of onychomycosis of the toenail. Dates of Project: 2003-Ongoing

7. Project N: 03-7-005 Role: Bustamante B., Co-Investigator Source: Fujisawa Healthcare, Inc. Title of Project: "A phase 3, randomized, double-blind, comparative trial of micafungin (FK463) versus Fluconazole for the treatment of esophageal candidiasis". The major goal of this project is: To determine the efficacy and safety of intravenous micafungin versus intravenous fluconazole in the treatment of patients with esphageal candidiasis. Dates of Project: 2003-Ongoing

8. “Actividad antifúngica y antioxidante de Gentianellanitida (Grisebach) Fabris e Iryanthera lancifolia Ducke” Prtincipal Investigator: Olga LockINgeniero quimico Co-Investigator: Beatriz Bustamante M.D Funding: SECAB (Secretaria ejecutiva del Convenio Andrés Bello-Colombia) Dates: 2003-Ongoing

9. "Mycotic etiology of respiratory involvement among HIV patients" Funding agency: Directorate General for International Collaboration (DGIS), Belgium through the Tropical Medicine Institute "Prince Leopold", Antwerpen. Dates: 2003-Ongoing “Genomic Analyses of Sporothrix schenckii using Fluorescent Amplified Fragment Length Polimorphisms (fAFLP)” Principal Investigator: MSc Edgar Neyra Co-Investigator: Beatriz Bustamante M.D. Funding agency: Directorate General for International Collaboration (DGIS), Belgium through the Tropical Medicine Institute "Prince Leopold", Antwerpen. Dates: 2002-Ongoing

10. PUBLICACIONES • (No se incluyen presentaciones y publicacones nacionales) • Last Papers and Chapters • Pappas P, Bustamante B, Ticona E, Hamill RJ, Johnson P, Reboli A, • Aberg J, Ellner J, Hasbun R, Hsu H. Recombinant Interferon Gamma • as adjunctive therapy for acute cryptococcal meningitis. • JID Manuscript in press • Chapman SW, Pappas P, Kauffmann C, Smith EB, Dietze R, • Tiraboschi-Foss N, Restrepo A, Bustamante B, Opper C, • Emady-Azar S, Bakshi R. Comparative evaluation of the efficacy • and safety of two doses of terbinafine (500 and 1000 mg/day) • in the treatment of cutaneous or lymphocutaneous sporotrichosis. • Mycoses 2004; 47. Manuscript in press.

11. Rojas R, Bustamante B, Bauer J, Fernández I, Alban J, Lock O. • Antimicrobial activity of selected Peruvian medicinal plants. • J. Ethnopharmacol 2003, 88 (2-3): 199-204. • Bustamante B, Campos P. Eumycetoma. In: Clinical Mycology, • edited by William E Dismukes, M.D., Peter G. Pappas, M.D., • and Jack D. Sobel, M.D. Oxford University Press . 2003. • Godoy P, Tiraboshi IN, Severo LC, Bustamante B, Calvo B et al. • Species distribution and antifungal susceptibility profile of • Candida spp. bloodstream isolates from Latin American Hospitals. • Mem Inst Oswaldo Cruz, Rio de Janeiro. 2003; 98(3):401-405.

12. LAST POSTERS • Rojas R, Bustamante B, Bauer J, Fernandez I, Lock O. • Screening of Antimicrobial Activity of Some Peruvian • Medicinal Plants. 3th World Congress on Medicinal and aromatic • Plants for Human Welfare. February 3-7, 2003. Chiang Mai, Thailand. • Puell L, Velasquez F, Farias H, Ballona R, Escalaya R, • Bustamante B y col. Esporotricosis en niños: Tres formas clínicas • de presentación. III Congreso Latinoamericano de Dermatología • Pediátrica. Mayo 1-4, 2003-Lima Perú. • Negroni R, Tobon A, Bustamante A, Yasuda M, Hare R, Patiño • H, and Restrepo A. Posaconazole (POS) Treatment of Mycetoma and • Chromoblastomycosis. 43nd Annual ICAAC.September 14-17,2003 • Chicago, IL-USA.

13. Pitisuttithum P, Gaona-Flores V, Negroni R, Sanne I, Graybill JR, • Bustamante A, Hare R, and Hardalo C. Efficacy of Posaconazole • (POS) in Treatment of Central Nervous System (CNS) • Fungal Infections: Results of an Open-Label Study . 43nd Annual • ICAAC.September 14-17,2003 Chicago, IL-USA.

14. PROYECTOS FUTUROS • Cryptococcus neoformans IN THE DOMICILE: A POTENTIAL RISK FACTOR • FOR INVASIVE CRYPTOCOCCOSIS FOR HIV POSITIVE PATIENTS • Objetives: To evaluate whether the colonization of household environment by • C. neoformans is a risk factor for cryptococcal disease in HIV-infected patients. • INCOPORATING MOLECULAR BIOLOGY TOOLS INTO • EPIDEMIOLOGICAL AND CLINICAL STUDIES OF CRYPTOCOCCAL • DISEASE IN PERÚ • Objetives: To evaluate the Amplified Fragment Length Polimorphism (AFLP) in • Clinical isolates of Cryptococcus neoformans. • EVALUATION OF THE POTENTIAL ROLE OF CATS AS VECTOR OF • S. schenckii IN AN HYPERENDEMIC AREA OF SPOROTRICHOSIS: A PILOT • STUDY. • Objetives: To measure frecuency of presence of S. schenckii in nails and hair of • domiciliary cats.