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Days post-sham injury

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Days post-sham injury

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  1. Supplemental Figure 1. Representative photomicrographs of phospho-S6RP expression in NeuN-, IBA-1- and GFAP-positive cells at 24 h after sham injury (n = 3). Robust expression of phospho-S6RP was detected in cortical and hippocampal neurons (NeuN+ cells). Occasionally, p-S6RP expression was detected in microglia (IBA-1+ cells) and astrocytes (GFAP+ cells) in cortical but not hippocampal brain regions. Scale bar, 30 um.

  2. A B Latency (s) ---Hidden platform--- -Visible- -Probe- 1 2 3 4 5 1 2 1 2 Score Trial # Days post-sham injury Supplemental Figure 2. (A) Dual inhibitor treatment with Akt inhibitor viii (12.5 uM) and rapamycin (12.5 uM) administered intracerebroventricularly before sham injury does not influence motor function assessed by the wire grip test (n = 6/group). (B) No effect of Akt viii and rapamycin inhibitors given in the concentrations shown on postinjury Morris water maze testing after controlled cortical impact (n = 6/group).

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