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MHC in Immune System

CZ5226: Advanced Bioinformatics Lecture 3: MHC Molecules Prof. Chen Yu Zong Tel: 6874-6877 Email: csccyz@nus.edu.sg http://xin.cz3.nus.edu.sg Room 07-24, level 7, SOC1, National University of Singapore. MHC in Immune System. MHC in Immune System. MHC in Immune System. MHC in Immune System.

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MHC in Immune System

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  1. CZ5226: Advanced BioinformaticsLecture 3: MHC MoleculesProf. Chen Yu ZongTel: 6874-6877Email: csccyz@nus.edu.sghttp://xin.cz3.nus.edu.sgRoom 07-24, level 7, SOC1, National University of Singapore

  2. MHC in Immune System

  3. MHC in Immune System

  4. MHC in Immune System

  5. MHC in Immune System

  6. MHC in Immune System

  7. MHC in Immune System

  8. T-Cell Recognition of Peptide Antigen through MHC-peptide complex

  9. T-Cell Recognition of Allogeneic MHC

  10. Classes of MHC

  11. Antigen capture and display

  12. Antigen capture and display

  13. Cross Presentation of Antigens

  14. MHC Genes

  15. MHC Genes

  16. MHC Genes

  17. Properties of MHC genes

  18. Properties of MHC genes

  19. Properties of MHC Genes

  20. Properties of MHC Genes

  21. Properties of MHC Genes

  22. Structure of MHC

  23. MHC Gene and Protein Structure

  24. MHC protein structure

  25. MHC protein structure

  26. Peptide Binding to MHC

  27. Peptide Binding to MHC

  28. MHC-peptide structure

  29. MHC-peptide structure

  30. Peptide Binding to MHC

  31. Peptide Binding to MHC

  32. Peptide Binding to MHC

  33. Peptide Binding to MHC

  34. Peptide Binding to MHC

  35. MHC and Diseases

  36. MHC and Diseases

  37. Summary of MHC • MHC-I consist of an alpha chain and beta-2 microglobulin and present endogenous peptides to T lymphocytes, which are processed by the cytosolic pathway in APC. • MHC-II have alpha and beta chains and present to T cells exogenous peptides processed by the endocytic pathway. • Non-classical MHC are involved in antigen processing, presentation and tolerance induction. • Minor H antigens are genetic variants of peptides presented by MHC to T cells and cause graft rejection and graft versus host reaction. • HLA has an association with autoimmune disease due to its capacity of altering antigen presentation and clearance, lympocyte activation and tolerance induction.

  38. Summary of Today’s lecture • Adaptive immune system • Comparison between innate and adaptive immune system • Relevant cells and related molecules

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