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TSH and You!

TSH and You!. By: Kayla Smith & Erica Barber. Intro. Who: Thyroid-stimulating hormone/ Thyrotropin (TSH) What: Peptide hormone Where: Secreted from the Anterior Pituitary When: Starts independent production in 2 nd trimester.

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TSH and You!

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  1. TSH and You! By: Kayla Smith & Erica Barber

  2. Intro Who: Thyroid-stimulating hormone/ Thyrotropin (TSH) What: Peptide hormone Where: Secreted from the Anterior Pituitary When: Starts independent production in 2nd trimester. Produced throughout life. Decreased production in old age. Why: Metabolism Regulation, Growth How: TSH enters general circulation to reach Thyroid gland

  3. Materials & Methods • 2 control / 2 experimental • Injections at 10:00 AM each day for 2 weeks • Test hormone dose 25% above Physiological concentration • Control rats received a daily injection of saline. • 14:10 day/ night cycle of light • Euthanized by an intraperitoneal injection of sodium pentobarbital • Changes greater than 20% considered significant.

  4. Results

  5. Overview

  6. Diseases Hyperthyroidism • Poor heat tolerance • Rapid weight loss • More energy • Agitated/ fidgety /Irritability • Muscle wasting • High heart rate Hypothyroidism • Weight gain • Poor cold tolerance • Low heart rate • Fatigue easily • Poor memory

  7. Possible Treatments • Antithyroid medications • Radioactive Iodine • Thyroidectomy

  8. References • Richard W. Hill, Gordon A. Wyse, Margaret Anderson. (2008). Animal Physiology. 2nd ed. Sunderland, Massachusetts: Sinauer Associates. • R.F. Lauff, A. Beye, W.S. Marshall. (2012). Comparitive Vertebrate Physiology. Antigonish, N.S.: St. Francis Xavier University Press. • StéphaneLair, Graham J. Crawshaw, Kay G. Mehren, Maria A. Perrone(Dec., 1999), Diagnosis of Hypothyroidism in a Western Lowland Gorilla (Gorilla gorilla gorilla) Using Human Thyroid-Stimulating Hormone Assay. Journal of Zoo and Wildlife Medicine. Vol. 30, No. 4 pp. 537-540: American Association of Zoo Veterinarians:http://www.jstor.org /stable/20095917 • C. M. Odenweller, C. T. Hsu, E. Sipe, J. P. Layshock, S. Varyani, R. L. Rosian,S. E. DiCarlo. (1997).LABORATORY EXERCISE USING "VIRTUAL RATS" TO TEACH ENDOCRINE PHYSIOLOGY. Bethesda M.D.: The American Physiological Society.: http://advan.physiology.org/content/273/6/S24.full.pdf • Photo references • http://www.naturalremedies.org/hyperthyroidism/ • http://www.jcrow.com/hypothyroidism.html • Http://advan.physiology.org/content/273/6/S24.full.pdf • http://endocrine.niddk.nih.gov/pubs/Hypothyroidism/ • http://www.drugs.com/health-guide/thyroidectomy.html • http://www.howtogetpregnantchances.com/dealing-with-conceiving-after-coming-off-the-pill.html

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