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Chapter 5d: The Structure and Function of Macromolecules (Nucleic Acids)

Chapter 5d: The Structure and Function of Macromolecules (Nucleic Acids). Polymers, Monomers, and Lipids. Nucleic-acid monomers consist of three components: a sugar, a nitrogenous base, and phosphate Deoxyribonucleic acid (DNA) vs. Ribonucleic acid (RNA). Nucleic acid. Central Dogma. Lipid.

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Chapter 5d: The Structure and Function of Macromolecules (Nucleic Acids)

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  1. Chapter 5d:The Structure andFunction ofMacromolecules(Nucleic Acids)

  2. Polymers, Monomers, and Lipids • Nucleic-acid monomers consist of three components: a sugar, a nitrogenous base, and phosphate • Deoxyribonucleic acid (DNA) vs. Ribonucleic acid (RNA)

  3. Nucleic acid Central Dogma Lipid Protein Nucleic acid Nucleic acid Nucleic acid + protein Nucleic acid

  4. DNA and RNA Note

  5. DNA and RNA This is basically the level at which you will learn this

  6. ribose deoxyribose Ribose & Deoxyribose Note the lack of a 2’ OH

  7. Adenosine Monophosphate Nucleotide Nucleoside Monophosphate Adenosine Monophosphate

  8. Adenosine Monophosphate Yes, Memorize Me—including numbers DNA or RNA?

  9. AMP, ADP, ATP

  10. 5’ Carbon Note Carbon Pi is Attached to

  11. Smaller word, bigger structure Nitrogenous Bases Bigger word, smaller structure

  12. DNA and RNA No need to know structures, but do know where on the sugar they attach as well as which are purines and which are pyrimidines

  13. Sugar-Phosphate Backbone Pi-5’-4’-3’-Pi-5’-4’-3’-Pi-5’-4’-3’-Pi Note Phosphodiester linkage

  14. Base Pairing Note that the resulting strand complementarity does not mean that the two strands have the same sequence

  15. DNA and RNA Note that T pairs with A (T:A) and C pairs with G (G:C)

  16. Note how the two strands are anti-parallel to each other Twisting into Helix

  17. Base Pairing & Double Helix Replicating DNA

  18. Relative Sizes Biomolecules E. coli 2000 nm = 2 m = 0.002 mm

  19. The End

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