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Proposed changes to hemoglobin and donation interval criteria for whole blood donors: Projected impact on current don

Proposed changes to hemoglobin and donation interval criteria for whole blood donors: Projected impact on current donor base. Anne Eder, MD PhD Executive Medical Officer Blood Products Advisory Committee Meeting . July 27, 2010. Four Questions.

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Proposed changes to hemoglobin and donation interval criteria for whole blood donors: Projected impact on current don

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  1. Proposed changes to hemoglobin and donation interval criteria for whole blood donors:Projected impact on current donor base Anne Eder, MD PhD Executive Medical Officer Blood Products Advisory Committee Meeting July 27, 2010

  2. Four Questions • What would be the impact of changing the minimum predonation Hemoglobin (Hb) from 12.5 g/dL… • …to 13.0 g/dL for men? …to 13.5 g/dL for men? 2. …to 12.0 g/dL for women? • What would be the impact of changing the interdonation interval from 8 weeks (about 6-7 times per year) ….. • ….to 12 weeks (about 4-5 times per year) for men? • ….to 16 weeks (about 3-4 times per year) for women?

  3. Balance Sheet

  4. American Red Cross, 2010 Annual Data – (Denominator) 6 M Red Cells 1.7 M Plasma Products 850,000 Apheresis Platelets 250,000 WB-derived Platelets 40,000 Pooled Platelets Puerto Rico

  5. Hb Distribution, Presenting Donors Male Female NHLBI Retrovirus Epidemiology Donor Study-II (REDS-II) New England Region, ARC, 2008-2009

  6. Question 1: Minimum Hb for Men • Hb 12.5 →13.0 g/dL for men • Hb 12.5 →13.5 g/dL for men *NHLBI Retrovirus Epidemiology Donor Study-II (REDS-II) New England Region, ARC, 2008-2009

  7. Question 2: Minimum Hb for Women • Hb 12.5 →12.0 g/dL for women *NHLBI Retrovirus Epidemiology Donor Study-II (REDS-II) New England Region, ARC, 2008-2009

  8. Questions 1&2: Minimum Hb

  9. Questions 3 & 4: Frequency American Red Cross, Cohort of CY2008 whole blood donors followed for 365 days (6,466,231 donations)

  10. Questions 3 & 4: Frequency *Based on fractional estimates for frequency: 4.33 for men; 3.25 for women American Red Cross, Cohort of CY2008 whole blood donors followed for 365 days (6,466,231 donations)

  11. Balance Sheet

  12. Conclusions • In the ARC system, changing the minimum hemoglobin requirement to13.0 g/dL for men and 12.0 g/dL for women is predicted to have little effect on total collections • Changing the donation interval is predicted to have a significant, detrimental effect on collections

  13. Donation Frequency – Cohort • Day 1              Donation 1 • Day 57            Donation 2 • Day 113 Donation 3 • Day 169          Donation 4 • Day 225          Donation 5 • Day 281          Donation 6 • Day 337          Donation 7 • And 28 days left until New Years.

  14. Model Donation Interval Original Interval 0 56 d 56 d 56 d 56 d 56 d = 6 donations New Interval 0 112 d 112 d = 3 donations

  15. Donation Interval – Male Donors

  16. Donation Interval – Female Donors

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