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HYPOTHESES INFLUENCE OF ANTAGONISM ON DRUG ACTION

HYPOTHESES INFLUENCE OF ANTAGONISM ON DRUG ACTION. NULL HYPOTHESIS Effect on intestinal motility Acetylcholine = NSS= Acetylcholine + Atropine = Acetylcholine + Epinephrine ALTERNATIVE HYPOTHESIS Effect on intestinal motility

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HYPOTHESES INFLUENCE OF ANTAGONISM ON DRUG ACTION

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  1. HYPOTHESESINFLUENCE OF ANTAGONISM ON DRUG ACTION • NULL HYPOTHESIS • Effect on intestinal motility • Acetylcholine = NSS= Acetylcholine + Atropine = Acetylcholine + Epinephrine • ALTERNATIVE HYPOTHESIS • Effect on intestinal motility • Acetylcholine ≠ NSS ≠ Acetylcholine + Atropine≠ Acetylcholine + Epinephrine

  2. EXPECTED RESULTSINFLUENCE OF ANTAGONISM ON DRUG ACTION • Reject Null, Accept Alternative Hypothesis • Effect on intestinal motility • Acetylcholine ≠ NSS ≠ Acetylcholine + Atropine≠ Acetylcholine + Epinephrine • Ach > NSS > Ach-Epinephrine > Ach-Atropine

  3. EXPERIMENTAL RESULTSINFLUENCE OF ANTAGONISM ON DRUG ACTION * % DISTANCE TRAVELLED BY INDIA INK

  4. STATISTICAL ANALYSIS F< F crit: Not statistically significant

  5. STATISTICAL ANALYSIS

  6. GRAPHICAL PRESENTATION Mean % distance travelled by india ink Graph 1. Batch Mean of % distance travelled by the India ink in the 4 treatment groups

  7. STATISTICAL ANALYSIS ANALYSIS OF VARIANCE (casualties not included) • *Significance level of 5% • INTERPRETATION: If F < Fcrit, Accept Null Hypothesis

  8. STATISTICAL ANALYSIS • F: 0.198913 • F crit: 2.991241 • Since (F) < (Fcrit) at α= 0.05 • We fail to Reject Null Hypothesis • Accept Null Hypothesis • Effect on GI Motility: • Acetylcholine = NSS= Acetylcholine + Atropine= Acetylcholine + Epinephrine

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