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D BP is Sensitive to DA Kinetics For illustration, Consider DA spikes of Constant Area

D BP is Sensitive to DA Kinetics For illustration, Consider DA spikes of Constant Area. DA Conc. (nM). DA Conc (nM). D BP. D BP varies with timing of the DA response. (the impulse response is time-varying). Yoder, Wang, & Morris (2004) J Nuc Med, 45(5) 903-911. raclopride. DA.

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D BP is Sensitive to DA Kinetics For illustration, Consider DA spikes of Constant Area

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  1. DBP is Sensitive to DA Kinetics For illustration, Consider DA spikes of Constant Area DA Conc. (nM) DA Conc (nM) DBP DBP varies with timing of the DA response. (the impulse response is time-varying) Yoder, Wang, & Morris (2004) J Nuc Med, 45(5) 903-911.

  2. raclopride DA Did we discover this? Endres CJ, Carson RE. (1998) Assessment of dynamic neurotransmitter changes with bolus or infusion delivery of neuroreceptor ligands. J Cereb Blood Flow Metab 18:1196-1210 they said… (1)

  3. The free tracer is the “shutter” of the “dopamine-camera” DA time Free 11C-raclopride FRAC(t) Free dopamine, DA(t) The picture (DBP) is “weighted” by the scenes when the shutter is open widest.

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