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Remembering the Future: Mothers Knows Best

Adam Franssen, Kelly Rafferty, Sarah Byce, and Craig Kinsley. Remembering the Future: Mothers Knows Best. In the Beginning…. Effects of Parenthood on Parents. ???. Effects of Pregnancy: Boldness. Effects of Pregnancy: Better Foraging. Effects of Pregnancy: Better Non-Spatial Memory.

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Remembering the Future: Mothers Knows Best

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  1. Adam Franssen, Kelly Rafferty, Sarah Byce, and Craig Kinsley Remembering the Future: Mothers Knows Best

  2. In the Beginning…

  3. Effects of Parenthood on Parents ???

  4. Effects of Pregnancy: Boldness

  5. Effects of Pregnancy: Better Foraging

  6. Effects of Pregnancy: Better Non-Spatial Memory

  7. Effects of Pregnancy: Better Spatial Memory Habituation: Days 1-4 Tests: days 5-8 Measures: Latency to approach baited and non-baited wells, number of baited and non-baited wells visited, latency to eat first/only Froot Loop, total time to find and eat all FLs, number of FLs found and eaten

  8. Effects of Pregnancy: Mothers are less likely to suffer from Alzheimers Virgins Mothers

  9. Effects of Pregnancy: Mothers suffering TBI outperform ControlVirgins at memory tasks Virgin KA Mother KA

  10. And then there was prospective memory… (and it was good)

  11. What ISProspective Memory? • Types of Memory • Working Memory – actively trying to remember something • Retrospective – recalling event from the past • Prospective – the anticipation of future events

  12. Who utilizes PM? ?

  13. What do RATS have to remember? • Retrospective: • Where are the best places to find food? • How do I get back to my nest? • Prospective: • Remember to maximize my foraging so that I have enough food to survive drought conditions

  14. Mothers vs. Non-Mothers • Given: Reproductive experience modifies a host of behavioral, neurobiological and physiological features. • We hypothesize that it is evolutionarily advantageous for mothers to remember to forage more efficiently in order to better care for their young

  15. Experimental Design • Mother, Virgin, and Male rats are deprived of water for 16 hours • They are then placed in an Open Field Maze (OFM) for 30 minutes and allowed to forage for water Rat in the Open Field Maze

  16. Experimental Design • Next, rats are placed back into their home cage where: • Control rats have water • Experimental rats do NOT have water • After returning to the home cage, rats are placed back into the open field maze. • If the rats are using prospective memory, experimental rats should spend more time drinking in the maze than the control rats.

  17. Mother in OFM Control

  18. Mother in OFMExperimental

  19. Data Suggest That Mother Rats (Primiparous Females)Are Utilizing Prospective Memory Mothers spend more time drinking than other groups p = 0.03; n = 6; Mean + SEM No significance w/in groups n = 6; Mean + SEM Time Spent Drinking Latency To Find Water

  20. Preliminary Conclusions I • MaleandVirginrats did NOT demonstrate prospective memory • Regardless of condition, males and virgins spent the same time drinking while in the OFM

  21. Preliminary Conclusions II • Mother rats demonstrated prospective memory • Experimental moms drank more water in the OFM – indicating that they knew that there would not be water in the home cage • Control moms drank less – indicating that they knew water was going to be available in their home cage. Why the difference between groups?

  22. Current/Future Directions • Investigate the brain! • Where is the brain activated during prospective memory? cfos activation no cfos activation

  23. Current/Future Directions • What about dads?

  24. Current/Future Directions:Peromyscuscalifornicus Monogamous/Biparental Dad caring for young Franssen et al. 2010 J Neurosci(in prep)

  25. Acknowledgements Catherine and Elle Kinsley Lab

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