1 / 2

human cardiac stromal cells

Human cardiac stromal cells are derived from whole hearts that have been dissociated into single cells and cultured using differential adhesion. Human cardiac stromal cells are from a single donor. Learn more from https://www.creative-bioarray.com/Human-Cardiac-Stromal-Cells-CSC-C2846-item-1944.htm

creativebioarray22
Download Presentation

human cardiac stromal cells

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. ThePhysiologicalFunctionofHumanCardiacStromalCells ◆supportingandarrangingHumanCardiacStromalCells,maintainingthenormalstructureof myocardium. ◆ surroundedbyHumanCardiacStromalCells,topreventtheHumanCardiacStromalCells overextensionandfracture. ◆AssistthetransferofcontractileforcebetweenHumanCardiacStromalCells. ◆reserveenergyfortheHumanCardiacStromalCellsinthenextcardiaccycletostretch. Inadditiontotheaboverole,recentstudieshaveprovedthatitisthedeterminantofmyocardial hardness.MyocardialtissueconsistsofHumanCardiacStromalCellsandinterstitialcells.Human CardiacStromalCellsaccountforabout75%ofthevolumeofmyocardialtissue,amongwhich theinterstitialtissueonlyaccountsfor25%ofthevolumeofmyocardialtissue,butthenumber ofHumanCardiacStromalCellsistwicethatofHumanCardiacStromalCells,including endothelialcells,vascularsmoothmusclecellsandfibroblasts.Accordingtothedistributionand functionofcollageninmyocardium,itcanbedividedintointerstitialcollagen,basalmembrane collagenandextracellularcollagen,amongwhichinterstitialcollagenisthemaintype. MyocardialinterstitialcollageniscomposedofcollagentypeI~VI,mainlyfortypeI(80%)and Ⅲtype(11%),collagen,issecretedbyfibroblastsynthesis;Inaddition,smallamountsoftypeIV andVaresecretedbyfibroblastsandcardiomyocytes.TypeVIcollagenissynthesizedby fibroblastsandendothelialcells.Underphysiologicalconditions,collagenrenewalisveryslow withahalf-lifeof80-120days,butcollagendegradationissignificantlyacceleratedwhentissueis rapidlyreconstructed. ThegrowthofHumanCardiacStromalCellsandinterstitialcellshavetheirownregulatory mechanisms,whichareindependentofeachother.TheproliferationofHumanCardiacStromal Cellsmaynotbeaccompaniedbytheproliferationofinterstitialcells,andtheproliferationof interstitialcellsmaynotbeaccompaniedbythehypertrophyofHumanCardiacStromalCells,but thesetwopartsareregulatedbythehormonesofgrowthfactors.Cardiachypertrophyisa responseofcardiacmyocytesandcardiacinterstitialcellstohormonesandgrowthfactors.The

  2. combinationofthesepro-cardiachypertrophyfactorswiththereceptorcausesconformationalcombinationofthesepro-cardiachypertrophyfactorswiththereceptorcausesconformational changesofthereceptor,activatesthecorrespondingproteinkinase,andphosphorylatessome specifictranscriptionfactors,soastotransmitthegrowthfactorsignaltothenucleus,regulate geneexpressionatthetranscriptionlevel,andgeneratetheresponseofcardiacmyocytesand interstitialcells. AboutCreativeBioarray CreativeBioarrayisaninnovativebiotechnologycompanywhosemissionfocuseson developinguniquetechnologiesthatprovideglobalscientistswithhighqualityproductsand satisfactoryservicestofacilitatetheinvestigationoflifescienceresearches. Weprovideawiderangeofhighqualitynormalhumanandanimalcells,cellculturemedium andreagents,FISHprobes,tissuearrays,microorganismsandequipments.Inaddition,we alsoofferseriesofrelatedservicesincludingcellservices,biosampleservicesandhistology servicesfortheresearchertomaketheirprojectbetterandfaster.

More Related