1 / 15

Glukoneogenesis

Glukoneogenesis. Definisi : Senyawa bukan karbohidrat  Glukosa Dimana : Di hepar (terutama), mungkin di ginjal dan di usus Glukosa penting ! Otak mutlak memerlukan Di otot dapat dipakai sebagai substrat tanpa oksigen Sel darah merah hanya bisa memakai glukosa

danae
Download Presentation

Glukoneogenesis

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Glukoneogenesis • Definisi : Senyawa bukan karbohidrat  Glukosa • Dimana : Di hepar (terutama), mungkin di ginjal dan di usus Glukosa penting ! • Otak mutlak memerlukan • Di otot dapat dipakai sebagai substrat tanpa oksigen • Sel darah merah hanya bisa memakai glukosa • Dalam payudara  laktosa Perlu untuk membersihkan asam laktat Binatang memamah biak perlu membuat glukosa dari asam propionat

  2. Asam laktat  Glukosa Lewat sebagian TCA Cycle dan kebalikan glikolisis dengan tambahan 4 enzim baru • Piruvat Karboksilase • PEP Karboksi kinase • F 1,6 BPase • G 6Pase Gliserol  Glukosa Gliserol hasil lipolisis dari Trigliserida (triasil gliserol) di jaringan lipid. Gliserol dibawa ke hepar Asam amino glikogenik  glukosa

  3. PEP Karboksikinase • Pada manusia ada di dalam dan diluar mitokhondria ( juga sapi dan guinea pig) • Pada tikus hanya di luar mitokhondria • Pada unggas dan marmut hanya di dalam mitokhondia Malat danPEPpada manusia keluar dari mitokhondria Pada tikusmalat keluar, di luar diubah lagi menjadi oksaloasetat

  4. G G 6P F 6P Glukoneogenesis F 1,6 BP DHAP Gld 3P 1,3 BP Glrt 3P Glrt 2P Glrt PEP

  5. Fructose-6-phosphate 6-phosphofructo -1-kinase Fructose 1,6-bisphosphatase Fructose 1,6-bisphosphate Gluconeogenesis and Glycolysis are reciprocally regulated • Fructose 1,6-bisphosphatase is main regulatory step in gluconeogenesis. • Corresponding step in glycolysis is 6-phosphofructo-1-kinase (PFK-1). • These two enzymes are regulated in a reciprocal manner by several metabolites. + Citrate - AMP - F 2,6-BP Citrate - AMP + F 2,6-BP + Reciprocal control—prevents simultaneous reactions in same cell.

  6. F 1,6 BP Glukosa Gliseraldehid 3P 

  7. Asam Propionat  Glukosa • Hasil pencernaan dari sellulosa dalam lambung binatang memamah biak • Lewat suksinil KoA

  8. Asam amino glukogenik  glukosa

  9. Ala Cys Gly Ser Thr Trp Fates of Amino Acid degradation products Glucose Leu Lys Phe Trp Tyr Pyruvate Ile Phosphoenol- pyruvate Acetyl CoA Acetoacetate Citrate Asn Asp Oxaloacetate Isocitrate Gln Citric Acid Cycle Malate Arg His Pro Phe a-Ketoglutarate Glu Tyr Fumarate Ile Met Thr Val Succinyl CoA Glucogenic Ketogenic Both Glucogenic & Ketogenic Succinate

More Related