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Evolution of recombination and fluctuation of epistasis with or without coevolution

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Evolution of recombination and fluctuation of epistasis with or without coevolution

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    1. Evolution of recombination and fluctuation of epistasis (with or without coevolution) Sylvain Gandon1 & Sarah P. Otto2 1: Génétique et Evolution des Maladies Infectieuses Montpellier, France. 2: Department of Zoology, University of British Columbia Vancouver,Canada.

    3. Host-parasite coevolution and the evolution of sex

    4. Outline Theoretical framework 2. Simple models with epistasis fluctuations: - without coevolution - with host-parasite coevolution 3. Metapopulation models 4. Conclusions and perspectives

    10. Towards a synthesis

    11. Towards a synthesis Deterministic models: - Directional selection - Temporal variability - Spatial variability Stochastic models: - Drift and selection

    12. Analysis of red queen dynamics 1. Weak selection (QLE analysis): Recombination is (almost) never favored Epistasis is too strong in most models of interaction 2. Strong selection (simulations): Recombination is favored in the Matching Allele Model The fluctuation of epistasis plays a major role

    13. Towards a synthesis Deterministic models: - Directional selection - Temporal variability - Spatial variability Stochastic models: - Drift and selection

    14. A model without coevolution The model: haploid organism 2 locus (A et B) under selection 1 modifier locus M r : recombination between A and B r : recombination between M and A

    15. A model without coevolution

    16. A model without coevolution

    17. A model without coevolution

    18. A model without coevolution

    22. The model: 2 haploid organisms 2 locus (A and B) under selection 1 modifier locus M r : recombination between A and B r : recombination between M and A A model with coevolution

    23. A model with coevolution

    24. A model with coevolution

    25. A model with coevolution

    26. A model with coevolution

    27. A model with coevolution

    28. A model with coevolution

    32. A model with coevolution

    33. Metapopulation models

    34. Metapopulation models

    35. Metapopulation models

    36. Conclusions & perspectives One species and two species models yield similar results Two main factors are involved in recombination evolution: The « speed » of coevolution: - consistent with weak selection approximations - no “Barton zone” (except if migration or cost of recombination) The « geometry » of coevolution: - depends on recombination, mutation and migration Perspectives: Analyse the link with local adaptation Explore other models of interactions

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