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Systems Approaches for the Future of Biological and Biomedical Research

Systems Approaches for the Future of Biological and Biomedical Research. Some thoughts…. 1982. 1986. 1990. 1994. 1998. 2002. DNA sequence data: a starting point for genomics-based research. First microbial genome sequence completed. As of May 1, 2007: 550 published genomes

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Systems Approaches for the Future of Biological and Biomedical Research

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  1. Systems Approaches for the Future of Biological and Biomedical Research Some thoughts…..

  2. 1982 1986 1990 1994 1998 2002 DNA sequence data: a starting point for genomics-based research First microbial genome sequence completed As of May 1, 2007: 550 published genomes 1950 ongoinggenome projects

  3. One of the promises of genome projects, large and small, was that they would transform biology and medicine Parts list is a long way from the wiring diagrams and circuit logic needed to understand the link between genotype, environment, and phenotype

  4. Brain architecture and function • Development and evolution • Holistic approach to the study of disease • Human microbial communities Big questions in biomedicine require a systems approach(predictive quantitative biology)

  5. Other “-omics” approaches are required • But other “-omics” approaches are not enough • Data integration over multiple scales (time, space, etc. are essential) • Science at the interface of computing and biology The path forward

  6. “In Nature’s infinite book of secrets, a little can I read.” William Shakespeare “Antony and Cleopatra”

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