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Stem Cells and Cancer

Stem Cells and Cancer. Cancer Education Project University of Rochester. Stem Cells: The Good and The Bad. Stem Cells: What are they?. Yeah …. Can you divide and renew yourself ?. Stem Cell Recruitment Center. Stem Cells: What are they?. See, I’m still here!. Stem Cell Recruitment Center.

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Stem Cells and Cancer

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  1. Stem Cells and Cancer Cancer Education Project University of Rochester

  2. Stem Cells:The Good and The Bad

  3. Stem Cells: What are they? Yeah… Can you divide and renew yourself ? Stem Cell Recruitment Center

  4. Stem Cells: What are they? See, I’m still here! Stem Cell Recruitment Center

  5. Stem Cells: What are they? Yes, I’m unspecialized but my brother can become specialized. Watch him. You seem rather unspecialized. Can you give rise to specialized cells? Stem Cell Recruitment Center

  6. Stem Cells: What are they? My brother can become a skin cell. He specialized to form tight attachments to his neighbors… Stem Cell Recruitment Center

  7. Stem Cells: What are they? So do I get the job? You’re hired. You can start as one of our stem cells tomorrow Stem Cell Recruitment Center

  8. Stem Cells: Not like other cells… Self Renewal Stem Cell Stem Cell Progenitor Cell Undifferentiated Cell division and differentiation Red Blood Cell Platelet White Blood Cell

  9. Adult stem cells: Many different types… Adult stem cells contribute to homeostasis They divide only when needed Their progeny differentiate into cells that perform essential body functions. Neural Stem Cell Blood Stem Cell

  10. Cancer Stem Cells Cancer Stem Cell DNA mutations Cancer Progenitor Cell Cancer Stem Cell Uncontrolled, rapid cell division gives rise to improperly differentiated tumor cells

  11. Identifying Cancer Stem Cells Scientists can break up the cells of a tumor, then transplant each tumor cell into a new location…. Most of the tumor cells end up dying… Tumor But a rare few go on to grow a new tumor… Cancer Stem Cells

  12. Where might cancer stem cells come from? DNA mutations in normal stem cells may give rise to cancer stem cells

  13. Chemotherapy: Targets Rapidly Dividing Cells Stem cells do not divide rapidly, so are not targeted by chemotherapy. Conventional chemotherapy targets rapidly dividing cells. X X X

  14. Chemotherapy: Targets Rapidly Dividing Cells Tumor treated with chemotherapy The stem cell survives conventional chemotherapy and divides to form a new tumor Cancer Stem Cell

  15. What’s coming in cancer therapy? New targeted drugs that specifically kill cancer stem cells without harming normal stem cells should remove the “root” of the cancer. The rest of the cancer cells should die on their own, or conventional chemotherapy drugs can be used to kill these cells

  16. Scientists are searching for answers to these questions about cancer stem cells… What makes these cells different? What kinds of drugs can target these cells? What cellular pathways are affected by drugs that target these cells? Are there other possible drugs that target those pathways?

  17. Cancer Stem Cell Cartoon Work with your team to draw a stem cell cartoon strip that illustrates the answers to questions: • 3, 4 and 5, or • 6 and 7, or • 8 and 9

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