1 / 16

Introduction

Introduction. Diffusion Tensor Imaging (DTI) Effective technique in magnetic resonance imaging (MRI) for measuring anisotropic (directional) water diffusion in-vivo Can reveal useful information about tissue microstructure, particularly highly-anisotropic structures, e.g. white matter.

dima
Download Presentation

Introduction

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript


  1. Introduction • Diffusion Tensor Imaging (DTI) • Effective technique in magnetic resonance imaging (MRI) for measuring anisotropic (directional) water diffusion in-vivo • Can reveal useful information about tissue microstructure, particularly highly-anisotropic structures, e.g. white matter

  2. What do we measure?? • Fractional Anisotropy (FA) • Tells you how anisotropic (in a straight line) water movement is Completely straight (FA~1) Mostly straight (FA~0.5) All directions (FA~0)

  3. Diffusion in white matter • Myelinated axons in white matter restrict the direction of water diffusion

  4. Diffusion in White Matter Intact Axons

  5. Diffusion in White Matter Acute Injury WallerianDegneration

  6. Diffusion in White Matter So, we think that a person with a spinal cord injury will have LOWER FA! Loss of Anisotropic Diffusion

  7. How do we investigate? • Let’s group subjects into two categories: • Patients – subjects who have spinal cord injuries • Controls – subjects who have no spinal cord injuries • Try scanning one patient with a spinal cord injury, and one control subject with no injury

  8. Images Control Patient

  9. Results FA by Injury Category Fractional Anisotropy (FA) Injury Category

  10. Images Injury Level Control Patient

  11. Spine T1 T12

  12. Results FA vs. Spine Level Fractional Anisotropy (FA) Spine Level

  13. Results FA vs. Spine Level Fractional Anisotropy (FA) Spine Level

  14. Results FA vs. Spine Level Fractional Anisotropy (FA) Spine Level

  15. Results FA is lower in the injured patient than all controls! FA vs. Spine Level Fractional Anisotropy (FA) Injury level Spine Level

  16. Results We see a big decrease after the injury level in both patients! FA vs. Spine Level The more data we collect, the more certain we are about our results! Fractional Anisotropy (FA) Injury level Spine Level

More Related