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Manganese(II) Complexes as Potential Contrast Agents for MRI

Manganese(II) Complexes as Potential Contrast Agents for MRI. Contrast Agents for Clinical MRI ( T 1 ). T 1 contrast agents: Gd -DTPA, Gd -DOTA, Gd -oxalate… increase signals by decreasing the T 1 of protons. Left: normal brain MRI. Right: Brain MRI in presence of Gd 3+.

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Manganese(II) Complexes as Potential Contrast Agents for MRI

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  1. Manganese(II) Complexes as Potential Contrast Agents for MRI

  2. Contrast Agents for Clinical MRI (T1) T1 contrast agents: Gd-DTPA, Gd-DOTA, Gd-oxalate… increase signals by decreasing the T1 of protons Left: normal brain MRI. Right: Brain MRI in presence of Gd3+ Invest. Radiol. 1993, 28, 521-526.

  3. Gd3+ contrast agents have some problem nephrogenic systemic fibrosis What metal ion have more unpaired electrons? Mn2+

  4. Comparison of the stability constants[a] for the Mn2+complexes of the studied ligands with those for other relevant ligands discussed in the text. Defined as KML = [ML]/[M] [L]; KHML = [HML]/[ML] [H+]

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