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Topics. Presynaptic: transmitters general considerations criteria, types small molecules synthesis, location peptides roles, synthesis from precursors co-existence. Topics. Postsynaptic: second messengers access 7 transmembrane domain receptors, G proteins types

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Topics

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  1. Topics • Presynaptic: transmitters • general considerations • criteria, types • small molecules • synthesis, location • peptides • roles, synthesis from precursors • co-existence

  2. Topics • Postsynaptic: second messengers • access • 7 transmembrane domain receptors, G proteins • types • cAMP, AA, DAG, IP3 • protein kinases • truncating pathway • utility

  3. O CH3-C-O-CH2-CH2-N+-(CH3)3 + CoA HO- HO- HO- HO- -CH-CH2-NH2 -CH2-CH2-NH2 OH N H CAT acetyl CoA + choline acetylcholine AAAD TH tyrosine + O2 L-DOPA dopamine DBH dopamine norepinephrine OH HO- PNMT norepinephrine HO- -CH-CH2-NH-CH3 epinephrine TrH AAAD -CH2-CH2-NH2 tryptophan + O2 5-HTP serotonin GAD gamma-amino butyric acid (GABA) glutamate

  4. Principles, Table 15-3

  5. Principles, Fig. 15-2

  6. Principles, Fig. 13-2

  7. Principles, pg. 236

  8. Principles, Fig. 13-6

  9. Utility of second messengers • lengthening of signal • amplification of signal • divergence to several targets • convergence to single target • spatial spreading of signal • regulation of gene transcription

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