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Kaitlyn Nguyen and Naomi Tesfaiohannes Department of Biology Biological Databases

Kaitlyn Nguyen and Naomi Tesfaiohannes Department of Biology Biological Databases Loyola Marymount University October 1, 2019. Image from  http://drugcentral.org/. What is DrugCentral , and what type of data source is it? Does the content cover the database domain? 

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Kaitlyn Nguyen and Naomi Tesfaiohannes Department of Biology Biological Databases

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  1. Kaitlyn Nguyen and Naomi Tesfaiohannes Department of Biology Biological Databases Loyola Marymount University October 1, 2019 Image from http://drugcentral.org/

  2. What is DrugCentral, and what type of data source is it? • Does the content cover the database domain?  • How frequent are updates?  • Is DrugCentral convenient for the average user to use?  • When you run a sample query, do the information and results make sense? • Last thoughts and opinions on the overall usage and importance of the database

  3. What is DrugCentral, and what type of data source is it? • Does the content cover the database domain?  • How frequent are updates?  • Is DrugCentral convenient for the average user to use?  • When you run a sample query, do the information and results make sense? • Last thoughts and opinions on the overall usage and importance of the database

  4. DrugCentral is an open comprehensive drug information database • Public access • FDA approved drugs  • Data source: secondary (meta) • Human curated (in-house staff) • "Database developed and maintained by Oleg Ursu and Tudor Oprea. Web application developed by Jayme Holmes."(DrugCentral.org) Image from http://drugcentral.org/about

  5. DrugCentral is an open comprehensive drug information database • Who maintains the database? • Division of Translational Informatics at University of New Mexico with the IDG (Illuminating the Druggable Genome) • Funding from The National Institute of Health • An agency of the U.S. government (Department of Health and Human Services) responsible for biomedical and public health research Image from https://medicine.unm.edu/academic-divisions/translational-informatics/index.html Image from https://www.linkedin.com/company/national-institutes-of-health

  6. Searches can be made with drug, target, and  disease name

  7. DrugCentral database quality • Records of this database: 97,271 pharmaceutical formulations with FDA approved labels • Limited information on discontinued drugs and those approved outside the US • In the 2018 update, there are 11,241 human proteins and 4,240 other species entities covered in the database

  8. What is DrugCentral, and what type of data source is it? • Does the content cover the database domain?  • How frequent are the updates? • Is DrugCentral convenient for the average user to use?  • When you run a sample query, do the information and results make sense? • Last thoughts and opinions on the overall usage and importance of the database

  9. The last update was made in 2018 • Updated twice in the past three years • Made public in 2016 • Included in the 2017 Nucleic Acid Research Database issue • Cited 33 times Image from https://pubchem.ncbi.nlm.nih.gov/compound/6438472 Image from https://en.wikipedia.org/wiki/ChEMBL

  10. Example of drug search on DrugCentral for ibuprofen http://drugcentral.org/

  11. What is DrugCentral, and what type of data source is it? • Does the content cover the database domain?  • How frequent are the updates? • Is DrugCentral convenient for the average user to use?  • When you run a sample query, do the information and results make sense? • Last thoughts and opinions on the overall usage and importance of the database

  12. General Utility of DrugCentral • Yes! It is Convenient-to-use • "About" page: gives information on how and where the resources are created • Convenient to download information on a public computer, but on a private computer the file takes too much storage • Single search bar  • Search specific drug, target (areas), or diseases • Standard format •  This database has bar graphs and pie charts that summarize its information. It also has the name of the drug next to its definition and a structural representation of its makeup.

  13. Sample query • While attempting to create a query via Access 2016, the SQL files and other data would not download properly and open. • No option to change the file name from .sql or .zip --> .txt.

  14. Last thoughts and opinions on DrugCentral • User-friendly • Well-organized • Easily-accessible • Gives important and recent information on medical drugs and its relativity to a person(s) medical condition and/or disease • Provides information on dosage amount, molecular structure, etc.

  15. References on sources used for this presentation • Drugcentral. Retrieved on September 30, 2019 from http://drugcentral.org/ • National Institute of Health LinkedIn. Retrieved on September 30, 2019 from https://www.linkedin.com/company/national-institutes-of-health • The University of New Mexico School of Medicine translational informatics. Retrieved on September 30, 2019 from https://medicine.unm.edu/academic-divisions/translational-informatics/index.html

  16. Acknowledgements for this presentation • Loyola Marymount University  • Dr. Dahlquist  • DrugCentral Image from https://www.lmu.edu

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