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An Evaluation of Prostate Volume and Proton Therapy-Related Toxicities

An Evaluation of Prostate Volume and Proton Therapy-Related Toxicities Libby Krcik , BS, RT(T), Patrick Lee, MS, RT(T), CMD, Mingcheng Gao , PhD, Mark Pankuch , PhD, Megan Boroczk , BS, William Hartsell , MD Northwestern Medicine Chicago Proton Center. Purpose.

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An Evaluation of Prostate Volume and Proton Therapy-Related Toxicities

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  1. An Evaluation of Prostate Volume and Proton Therapy-Related Toxicities Libby Krcik, BS, RT(T), Patrick Lee, MS, RT(T), CMD, MingchengGao, PhD, Mark Pankuch, PhD, Megan Boroczk, BS, William Hartsell, MD Northwestern Medicine Chicago Proton Center

  2. Purpose • To analyze trends in the occurrence rate and severity of patient reported adverse proton beam therapy toxicities as a function of prostate size for low and intermediate risk prostate cancer patients.

  3. Background The severity of symptoms from benign prostatic hyperplasia (BPH) does not correlate with the degree of hyperplasia1 The prevalence of gross hematuria in patients with BPH is unknown2-4 Other urinary tract conditions can cause similar symptoms1 1. Edwards JL. Am Fam Physician. 2015. 2. Kearny MC, Bingham JB, Bergland R, Mead-D’Alisera P, Puchner, PJ. The Journal of Urology. 2002. 3. Foley SJ et al. The Journal of Urology. 2000. 4. Foley SJ. The Prostate Journal. 2000.

  4. Methods Prospective collection of data for 688 prostate cancer patients Proton Collaborative Group (PCG) registry study 70.0 Gy at 2.5 Gy per fx, OR 79.2 Gy at 1.8 Gy per fx Prostate size defined by MRI

  5. Methods Continued Patients divided into 5 groups Median follow up of 2.03 years Genitourinary, gastrointestinal, and dermatological toxicities collected Pearson chi-square test performed

  6. Gastrointestinal Results

  7. Dermatological Results

  8. Genitourinary Results Notable increases in grade 1 and 2 hematuria with increasing prostate size Very few high grade toxicities overall CT-CAE Definitions

  9. Prostate Size and Hematuria Correlation Grade 1 p-value= .019 Grade 2 p-value= .006

  10. Conclusion Most proton therapy-related toxicities exhibited no significant relationship to prostate volume Significant correlation between prostate size and incidence of low grade hematuria Low severity of symptoms in patients treated with proton therapy irrespective of prostate size

  11. Questions?

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