TOPICS IN (NANO) BIOTECHNOLOGY Course Outline

1. TOPICS IN (NANO) BIOTECHNOLOGY Course Outline 2nd October, 2006

2. Course Outline • Class runs every Monday, 09.00-11.00 and on every third Wednesday there will be an experimental demonstration, from October 2nd – for Nano MSc students • Class runs every Monday, 09.00-11.00 from October 2nd – for Chem Eng PhD students • There will a research visit to • CMN (Instituto de Microelectrónica de Barcelona) • ICMAB (Institut de Ciència de Materials de Barcelona) • (date to be decided)

3. Course Outline • The marks for the course will be based on • continuous assessment (60%) • reports • presentations • Final exam (20%) • Attendance (5%) • Must pass all segments of course for overall pass mark

4. Course Outline • The final exam consists of a multiple choice written exam and an oral presenatation • These exams will take place at the end of the first semester • The language of these exams will be English

5. Course Outline • Must attend at least 80% of classes • Website with password protection for uploading and downloading relevant documents will be available from next week • E-mail: ckosulli@etse.urv.es • Office: 213 • Hours for visits : Tuesday and Thursday 16.00 –18.00

6. Course Outline Fundamentals of Biotechnology Nanotechnology Nanobiotechnology

7. Course Details • FUNDAMENTALS IN BIOTECHNOLOGY • Class I • Definition of biotechnology and history • Class II • DNA – definition, structure, arrangement in cells • Class III • The Gene – definition, transcription, translation • Class IV • Proteins and Protein Structure, Enzymes and Antibodies • Class V • Recombinant DNA technology

8. Course Details • Class VI • Electrophoresis, Sequencing, PCR, Molecular Beacons, Real time PCR • Class VII • Dining & Sleuthing with DNA • Class VIII • Stem Cell Therapy and Gene Therapy • Class IX • The Human Genome Project • Genomics, transcriptomics and proteomics • Class X • Drug Discovery • Patents, intellectual property, and Tech Transfer

9. Course Details • NANOTECHNOLOGY • Class I • Nanotechnology: History, definitions and major milestones • Class II • ‘Bottom-down’ – Nanofabrication Techniques • Class III • ‘Top-up’- Biological self assembly • Class IV • Nanoparticle fabrication and biofunctionalisation • Class V • Nanotools: Microsopic techniques for characterisation and manipulation on a nanoscale

10. Course Details • NANOTECHNOLOGY • Class VI • Carbon Nanotubes • Class VII • Nanobiotechnology Applications: Diagnostics • Class VIII • Nanobiotechnology Applications: Therapeutics • Class IX • Nanobiotechnology Applications: DNA computing & DNA electronics • Class X • Nanobiotechnology Applications: Tissue Engineering / Artificial Organs

11. Course Details • Course resources • Handouts • Downloadable documents via website • With each class list of relevant websites provided • Relevant literature and books will be referenced according to each topic • Students anticipated to prepare themselves for classes of the following week and to be able to participate and contribute to the class – OPEN DISCOURSE WANTED!

12. Books Available • The Uses Of Life, A History of Biotechnology, Robert Bud • Industrial Enzymology, Godfrey & West • Biochemistry and Molecular Biology, Elliott & Elliott • Biomolecular Sensors, Gizelli & Lowe • Understanding Nanotechnology, Scientific American • Nanotechnology, A gentle introduction to the next big idea, Ratner & Ratner • Engines of Creation, Eric Drexler • Our Molecular Future, Douglas Mulhall • Nanobiotechnology, C. Niemeyer • Travels to the nanoworld, M. Gross