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VARIAN, INC. HPLC Products

VARIAN, INC. HPLC Products. Wide range of products in analytical LC High performance analytical instrumentation Choice of workstations Extensive range of columns and consumables Strongest sales and support team Excellent products and position in Preparative LC Custom prep skid systems

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VARIAN, INC. HPLC Products

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  1. VARIAN, INC. HPLC Products • Wide range of products in analytical LC • High performance analytical instrumentation • Choice of workstations • Extensive range of columns and consumables • Strongest sales and support team • Excellent products and position in Preparative LC • Custom prep skid systems • Flexible instrumentation • Solutions for Biochemists and Biologists

  2. Widest Range of Pumps Products in HPLC • Analytical Pumps • ProStar 210 Low cost isocratic analytical • ProStar 220 isocratic analytical • ProStar 230 ternary gradient analytical • ProStar 240 - quaternary gradient analytical • Preparative and Semi Preparative LC pumps • 210 - Low cost isocratic semi prep • PrepStar 218 - Low cost isocratic semi prep • PrepStar 210/218 binary and ternary gradients to semi prep • PrepStar SD-1 - Prep and scale up • PrepStar SD-2 – Low cost prep pump

  3. Widest Range of Detector Products in HPLC • UV-Vis detectors • ProStar 325 - high performance dual wavelength analytical/prep • ProStar 335 PDA detector • Other Detectors • ProStar 363 Fluorescence • ProStar 355 RI

  4. Widest Range of Sample Handling Products in HPLC • Autosamplers • 410 - High performance • 420 - Flexible, high performance • 430 - Well plate AutoSampler • Fraction collector • 701 - High performance, flexible

  5. Widest Range of Prep Products in HPLC • 500 CVM - Automated valving system • 510 Column oven • 530 Fluidics module • RamPak column packing stations • Lock and Load columns

  6. Configured systems • Polaris – Low cost educational system

  7. Widest Range of Software Products for HPLC • Galaxie – Client server multi PC, multi instrument network system • Instrument Control, Data Handling, Custom reports • ReSponder software – single PC, 1 instrument • Simple graphical control for prep, data acquisition but no data handling

  8. ProStar 220/230/240 Solvent Delivery Systems • Ease of use • No need to degas or He sparge • Simple pump priming • Reliability • Inlet valves do not fail • Older designs have been working 20+ years • Performance • Gradient performance at all flow rates

  9. ProStar 230/240 Solvent Delivery Systems • Mechanical Inlet Valve Design for improved flow delivery & reliability

  10. ProStar 210/218 Solvent Delivery Systems

  11. 210/218 Pump head • Different sizes for different flow rates • Different materials • Optional piston wash • Different pressure ratings (dependent on pump type)

  12. Pump Heads Available • Max flowMin flow • 5 mL 10 µL • 10 mL 10 µL • 25 mL 25 µL • 50 mL 50 µL • 100 mL 100 µL • 200 mL 200 µL

  13. Features, Benefits and Values • Feature Benefit • Prep and analytical Lower cost • Built-in ADC Lower cost • Choice of materials Biocompatible • Low price isocratic Affordable

  14. PrepStar SD-1 pump

  15. PrepStar SD-1 Pump Design • Twin pump heads • Independently driven motor on each pump head • Independent pressure transducer on each pump head controls flow independently • No pulsation throughout the entire flow range • NO PULSE DAMPENERS REQUIRED • Solvent compressibility • Flow accuracy + 0.010 mL/min (0.1 mL/min for 2 largest heads) • Flow precision + 0.001 ml/min (0.01 ml/min for 2 largest heads)

  16. PrepStar SD-1 Pump Benefits • Choice of 5 pump heads covering range of flows • 50, 200, 500, 800 and 3200 ml/min • Pump heads made of either stainless steel or titanium • Typical arrangement with 200 ml/min heads for best accuracy in 0.01 ml/min up to 200 ml/min range • Ideal for analytical to prep scale up applications • Optimize separation using inexpensive small diameter column at 1 ml/min • Switch valve to divert flow to preparative column packed with identical material at 200 ml/min • Low pump pulsations increases column lifetime

  17. PrepStar SD-2

  18. PrepStar SD-2 Features and Benefits • Low cost system • Performance for real prep customers • Controlled by ReSponder Prep software

  19. ProStar 325 Dual Wavelength UV-Vis Detector • Outstanding performance • Lowest noise of any dual wavelength detector • Dual wavelength with ratio capability • Widest dynamic range from 50 mAU to 70 AU • Handheld computer available to monitor chromatogram in real time, create and edit methods • Compatible with Galaxie and Star WS • Improved system monitoring

  20. 325 Optical design

  21. ProStar 325 Controlled Optical Imaging • Unique Advantage of COI • Minimize RI effects due to • gradient • injection • solvent • temperature

  22. 325 Features and Benefits • COI • No RI response to temperature, solvent or flow • Flatter baselines • Better data handling results • Best noise specification • Excellent sensitivity

  23. Flow cell - diagram

  24. ProStar 335 Photodiode Array • Outstanding performance • Programmable slit widths 1, 2, 4, 8, 16 microns optimizes noise or resolution • Excellent low noise operation < 1 x 10-5 AU • Monitor all l from 190 to 950 nm • Peak purity and spectral search available • Available in 2 versions • Analytical (single array) • Prep (dual diode)

  25. ProStar 335 PDA Optics

  26. ProStar 335 Features and Benefits

  27. ProStar 355 RI Detector • Outstanding performance • Active thermostating gives flatter baselines • Easy to use autozero improves analytical flexibility • Auto purge for automated runs • Wide dynamic range - 0.25 to 512x10-6 RIUFS • Compatible with Galaxie and Star WS

  28. ProStar 363 Fluorescence Detector

  29. ProStar 363 Optics Diagram

  30. ProStar 363 features and benefits • FeatureBenefit • Reference diode Low noise • Intense lamp High signal • Scanning Find optimum wavelength • Computer control Easy to use

  31. ProStar AutoSamplers • ProStar 410 – Most Common – 73% • Most common AutoSampler sold, 2 different vial sizes, Prep injections, standalone reuse of standards • ProStar 430 – Bio – 17% • Well plate AutoSampler

  32. ProStar 410 Autosampler

  33. ProStar 430 Autosampler • Automation of 96 or 384 well-plates

  34. ProStar 510 Column Valve Module • Outstanding flexibility • Valving for EVERY need • Simple, neat handling of analytical and semi-prep columns • Full software control • Solvent compatibility check • Compatible with Galaxie and Star WS

  35. PrepStar 530 – Fluidics Module

  36. PrepStar 530 capabilities • Interfaces the PrepStar SD-2 to ReSponder • Solvent selection for high pressure gradients • 4 A and 4 B solvents • Used with 2 pumps (SD-2, SD-1, PrepStar 218) • Solvent selection for low pressure gradients • Use 1 pump only, only SD-2 • Form stepped and linear gradients. • Fraction collecting • 11 fractions • Unique valves for high flow rates • “Blow out” feature puts all sample into collection vial

  37. PrepStar 530 capabilities • Recycle • Time program detector output back into pump and column • Sample injection • Inject sample through pump • Detector input to ReSponder software

  38. ProStar 701 Fraction collectors

  39. RamPak Column Packer

  40. Workstation • Star • Controls all mod and does full data handling • ReSponder – software for prep in the factory • Galaxie

  41. Positioning the ProStar and PrepStar • Widest range of products in HPLC • Excellent products and position in Preparative HPLC • Custom prep skid systems • Choice of workstations • High performance analytical instrumentation • Flexible instrumentation • Solutions for Biochemists and Biologists

  42. Full line of prep products - 1 • 210 pump with larger heads • Occasional semi prep • 218 pump with larger heads 200 mL/min • Routine semi prep • SD-1 pump • Scale-up to prep • SD-2 pump • Bench top prep • 325 detector • Dual path for extended range • Super prep flow cell • 335 PDA with prep flow cell • Diode array prep capability

  43. Full line of prep products - 2 • 701 Fraction collector • Flexible, controlled by the Galaxie workstation • 500 CVM with prep and diverter valves • Occasional fraction collecting capability – lower flows • 530 Fluidics module • Low pressure gradient with SD-2 • Solvent selector • Fraction collector • Sample injection • Recycle

  44. Full line of prep products -3 • 410 AutoSampler • Prep injection capability • Injection with 210/218 pump - AutoPrep • Inject any volume • Peak tracking software in Star • Complete package for prep • ReSponder software • Simple prep software • Control of the PrepStar 530 • RamPak column packing stations • Load and Lock columns

  45. Custom large prep systems • Up to 10 L/min • Up to 16 in. diameter columns • Custom designed and installed PCG ( Prep Chromatography Group) in Wakefield

  46. Flow Cell - Dual optical path • 9mm and 1 mm • 4 mm and 0.15 mm super prep cell • Extends linear range of the detector to greater than 10 AU • Automatic switching between the two paths at high absorbance

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