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FDA-Mandated Alternative to Bisphenol-A

FDA-Mandated Alternative to Bisphenol-A. Kristina Lenn Kevin Miles Gregory Jackett Isaac Norton August 5, 2010. Foreshadow. Introduction Effects of BPA on Human Physiology Possible Alternative Plastics to BPA Manufacturing Analysis Conclusion/Recommendation Questions. Introduction.

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FDA-Mandated Alternative to Bisphenol-A

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  1. FDA-Mandated Alternative to Bisphenol-A Kristina Lenn Kevin Miles Gregory Jackett Isaac Norton August 5, 2010

  2. Foreshadow • Introduction • Effects of BPA on Human Physiology • Possible Alternative Plastics to BPA • Manufacturing Analysis • Conclusion/Recommendation • Questions

  3. Introduction • Nalgene water bottles • BPA usage • FDA regulations

  4. Meet the Team • Kristina Lenn • Project Manager • Bachelor of Science in chemical engineering with an emphasis in biological engineering • Research on molecular modeling and computer simulation • Worked with Nalgene for one year

  5. Meet the Team • Kevin Miles • Team Leader during the Project Proposal • Bachelor of Science in chemical engineering with an emphasis in biological engineering • Research on tissue engineering • Worked with Nalgene for one year

  6. Meet the Team • Gregory Jackett • Team Leader during the Final Presentation • Bachelor of Science degree in chemical engineering with emphasis in molecular engineering and nanotechnology • Research on fatigue-induced muscle injury • Worked with Nalgene for one year

  7. Meet the Team • Isaac Norton • Team Leader during the Final Report • Bachelor of Science in chemical engineering with an emphasis in product and process design • Work experience in quality control • Worked with Nalgene for one year

  8. Background • BPA=Bisphenol-A • Polycarbonate • Chemical in water bottles and pop cans

  9. Problem • Recognized by the human body as estrogen • Absorbed by breast tumor cells • Promote breast and prostate tumor growths

  10. Task • BPA effects • Harmless Alternatives • Manufacturing Techniques

  11. BPA Effects on Human Physiology Kevin Miles

  12. A Look Ahead… • Previous Statements • Enviornmental exposure to BPA • BPA Leeching • The Endocrine system • BPA linked to cancer • Conclusion

  13. ~ 25 ng/kg/day 50,000 ng/kg/day Human Exposure: 52-74ng/kg/day http://www.google.com/imgres?imgurl=http://onwardstate.com/wp-content/uploads/2008/12/water_bottle-300x300.jpg&imgrefurl=http://onwardstate.com/2008/12/20/water-water-everywhere-but-a-storage-dilemma/&usg=__qNetutbQEJVjtGWRfq72AO1LwVU=&h=300&w=300&sz=11&hl=en&start=0&tbnid=WsPcp-pgT6AipM:&tbnh=115&tbnw=114&prev=/images%3Fq%3DWater%2BBottle%26um%3D1%26hl%3Den%26sa%3DN%26rlz%3D1G1GGLQ_ENUS367%26biw%3D740%26bih%3D411%26tbs%3Disch:1&um=1&itbs=1&iact=rc&dur=244&ei=xTVPTOe5HZKlnQemi6CQBw&page=1&ndsp=10&ved=1t:429,r:6,s:0

  14. How does the endocrine system work?

  15. BPA increased the level of hormone receptors produced by a prostate gland cell • Some dosages of BPA were environmentally relevant

  16. An increase in cell receptors fuels growth of the cell • Cells can proliferate out of control, resulting in cancerous tumor cells.

  17. Conclusions • BPA is harmful in lower doses • BPA can leech into food/beverages at relevant levels • BPA exposure increases risk of cancer

  18. Alternative Polymers Gregory Jackett

  19. The Line up • The Candidates • Strength • Toughness • Liquid Stability • UV Stability • Thermal Stability • The Ranking

  20. PETE(Polyethylene terephthalate)

  21. Atactic Polystyrene(PS)

  22. Eastman Tritan Copolyester ?

  23. Strength

  24. Toughness

  25. Liquid Stability

  26. UV Stability Copolyester?

  27. Thermal Stability

  28. The Ranking 1st Copolyester 2nd PETE 3rd Polystyrene

  29. Manufacturing Analysis Isaac Norton

  30. Forecast • Polymerization Method • Safety • Quality • Retooling • Ranking

  31. Method

  32. Safety

  33. Reaction Heat Runaway

  34. Quality

  35. The Ranking 1st Copolyester PETE 2nd 3rd Polystyrene

  36. Conclusions • Hazardous in small concentrations • Carcinogenic developmental changes • Copolyester’s better material properties • PETE’s better safety and quality properties

  37. Our Solution Is… PETE

  38. Just a Reminder… • The Problem • BPA Effects • Possible Alternatives • Manufacturing Comparison • The Solution

  39. References http://www.intuitive-recruitment.co.uk/ http://fondnessforreading.blogspot.com/2008/12/melting.html http://jalopnik.com/276775/wrecking-ball-on-the-loose http://www.better-leadership.com/great-offices.html http://www.greenerist.com/2009/02/green-tip-get-a-bpa-free-water-bottle/ http://health.allrefer.com/health/cancer-ovarian-cancer-metastasis.html http://www.tuxedoranch.com/images/featured/bpa-free-1.png http://www.sitnews.us/MacDougall/111207_PETE.jpg http://www.extension.iastate.edu/newsrel/reiman/PolystyrenePot.jpg http://www.innovationlab.eastman.com/NR/rdonlyres/4C99D9B3-B19A-4FD5-A60F-8115B0DF5064/0/example_lrg_camelbak1.jpg http://www.eastman.com/Brands/Eastman_Tritan/PublishingImages/TritanWater.jpg

  40. References http://i1.treklens.com/photos/5947/dscn0425c.jpg http://grail.cs.washington.edu/projects/office/dewey/china/photos/yunnan/hutiaoxia/middle/middle14.jpg http://www.jcu.edu/Philosophy/gensler/nc/images/10.jpg http://faculty.uscupstate.edu/llever/Polymer%20Resources/Isomerism.htm http://en.wikipedia.org/wiki/File:Ester-general.svg Taylor & Francis Group. (2010) Polymers, a property database. Retrieved from http://poly.chemnetbase.com

  41. Questions?

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