1 / 11

Clinical Metal Toxicology

Clinical Metal Toxicology. Introduction from chairman of the Medical Scientific Education and Research Committee of the International Board of Clinical Metal Toxicology. Historical Perspective. Concept of ligand theory proposed over a century ago – Swiss Nobel physicist Alfred Werner .

essien
Download Presentation

Clinical Metal Toxicology

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript


  1. Clinical Metal Toxicology Introduction from chairman of the Medical Scientific Education and Research Committee of the International Board of Clinical Metal Toxicology

  2. Historical Perspective • Concept of ligand theory proposed over a century ago – Swiss Nobel physicist Alfred Werner . • Metal ligand theory –foundation for the usage of chelating agents to bind heavy metals. • Dr.Norman Clark – usage of EDTA to treat plumbism ( lead poisoning ) post WW2 ; the beginnings of chelation medicine.

  3. 21st Century Perspective • There exist over fifty years of research in metal binding medicine and science; arguably the oldest and most establish field of medical specialty. • There exist over a thousand scientific papers on one of the chelating agent -EDTA! • The systemic effects of excessive free radical reactions catalyzed by excessive heavy metals causing free radical pathology is well established.

  4. IBCMT • The IBCMT was set up for the purpose of establishing a gold standard for the practice of clinical metal toxicology . • The IBCMT protocol is a comprehensive medical and scientific methodology on the optimal clinical management of patients in this specialty field . • Optimization of physiological, biochemical ,physical and mental health and precise nutrient distribution via detoxification of toxic metals and chemicals are fundamental to the desired medical outcomes.

  5. Environmental Health • The EPA ( USA ) has sounded the dire necessity of addressing the pollution of our environment and the serious toxic metal poisoning of the community. • Recent research has shown that accelerated age-related degenerative and neuro-degenerative diseases are linked to heavy metal poisoning . • IBCMT and the physician members of the sponsoring teaching colleges /chapters are poised critically in the position to address the EPA concerns and to play a crucial role in metal toxicology public health issues .

  6. Current clinical tools • Well established laboratory tests- spot urines ,provocative urines ,plasma and cellular biochemistry, hair analysis are utilized as baseline measurements and monitoring of treatment progress. • Current neuro-toxicity measurements are limited to subjective and semi-quantitative psychological testing and indirect inference from standard laboratory tests.

  7. Neuro-toxicity Assessment • Traditional radiological investigations – Plain films, CT scan, ultrasound, MRI mainly address anatomical issues . • Functional assessment of brain function is clinically critical for the measurement and monitoring of medical outcomes . • The BRC brain function testing involves a screening tool – the Integneuro assessment and a Comprehensive Psychological Test Battery.

  8. Memorandum of Understanding • Milestone signing of MOU between IBCMT and BRC . • IBCMT agree to adopt the BRC Integneuro system as one of the “gold” standards for the assessment of brain function. • This is an objective measurement of brain function based on the Brain Resource International Database ( BRID ).

  9. Key Factors of the MOU • The establishment of an embedded research program in clinical metal toxicology. • The availability of touch screen based kiosk to carry out screening assessment of brain function. • The distribution of research funding at the IBCMT , college and clinician level based on proceeds of brain function assessments.

  10. Embedded CPD • Continuing medical education is crucial to keep abreast of any medical field . • Current IBCMT re-certification requires all candidates to attend an advance metal toxicology workshop and to discuss two clinical cases of merit. • Participating in the embedded research is one way of achieving continue professional development ( CPD) and will raise the standards of our specialty field by another notch.

  11. Future of Clinical Metal Toxicology • The addition of BRC “gold” standard clinical tools and the availability of continued research funding at all levels would ensure an optimistic future for all concerned. • The research would yield information on specificity of brain function toxicity as caused by various toxic metals based on the BRID reference population. • IBCMT would utilize this database to enrich its protocol that would assist us in optimal clinical management of systemically toxic individuals.

More Related